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5P99
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BU of 5p99 by Molmil
rat catechol O-methyltransferase in complex with N-[2-[2-(3,4-dihydroxyphenyl)-2-oxoethyl]sulfanylethyl]-5-(4-fluorophenyl)-2,3-dihydroxybenzamide at 1.20A
分子名称: (4S,5S)-1,2-DITHIANE-4,5-DIOL, 2-[N-CYCLOHEXYLAMINO]ETHANE SULFONIC ACID, CHLORIDE ION, ...
著者Ehler, A, Lerner, C, Rudolph, M.G.
登録日2016-08-30
公開日2017-08-30
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (1.2 Å)
主引用文献Crystal Structure of a COMT complex
To be published
5P92
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BU of 5p92 by Molmil
humanized rat catechol O-methyltransferase in complex with 5-(4-fluorophenyl)-2,3-dihydroxy-N-(4-thieno[2,3-c]pyridin-2-ylbutyl)benzamide at 1.61A
分子名称: (4S,5S)-1,2-DITHIANE-4,5-DIOL, 2-[N-CYCLOHEXYLAMINO]ETHANE SULFONIC ACID, 5-(4-fluorophenyl)-2,3-dihydroxy-N-(4-thieno[2,3-c]pyridin-2-ylbutyl)benzamide, ...
著者Ehler, A, Lerner, C, Rudolph, M.G.
登録日2016-08-29
公開日2017-08-30
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (1.61 Å)
主引用文献Crystal Structure of a COMT complex
To be published
5P9S
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BU of 5p9s by Molmil
humanized rat COMT in complex with 8-hydroxy-6-[3-methyl-5-(4-methylpiperazine-1-carbonyl)thiophen-2-yl]-3H-quinazolin-4-one
分子名称: 6-[3-methyl-5-(4-methylpiperazin-1-yl)carbonyl-thiophen-2-yl]-8-oxidanyl-3~{H}-quinazolin-4-one, Catechol O-methyltransferase, MAGNESIUM ION, ...
著者Ehler, A, Jakob-Roetne, R, Rudolph, M.G.
登録日2016-10-19
公開日2017-11-22
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Crystal Structure of a COMT complex
To be published
5P9Z
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BU of 5p9z by Molmil
humanized rat COMT in complex with 6-(4-fluorophenyl)quinazolin-8-ol
分子名称: (4S,5S)-1,2-DITHIANE-4,5-DIOL, 6-(4-fluorophenyl)quinazolin-8-ol, CHLORIDE ION, ...
著者Ehler, A, Lerner, C, Rudolph, M.G.
登録日2016-10-19
公開日2017-11-22
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Crystal Structure of a COMT complex
To be published
5P9E
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BU of 5p9e by Molmil
rat catechol O-methyltransferase in complex with N-[2-(5-benzyl-1H-1,2,4-triazol-3-yl)ethyl]-5-(4-fluorophenyl)-2,3-dihydroxybenzamide at 1.50A
分子名称: (4S,5S)-1,2-DITHIANE-4,5-DIOL, CHLORIDE ION, Catechol O-methyltransferase, ...
著者Ehler, A, Lerner, C, Rudolph, M.G.
登録日2016-08-30
公開日2017-08-30
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献Crystal Structure of a COMT complex
To be published
5PAC
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BU of 5pac by Molmil
human factor VIIa in complex with 5-hydroxy-N-(4-oxo-3H-quinazolin-6-yl)-1-[3-[(phenylcarbamoylamino)methyl]phenyl]pyrazole-4-carboxamide at 1.50A
分子名称: 5-hydroxy-N-(4-oxo-3H-quinazolin-6-yl)-1-[3-[(phenylcarbamoylamino)methyl]phenyl]pyrazole-4-carboxamide, CALCIUM ION, CHLORIDE ION, ...
著者Stihle, M, Mayweg, A, Roever, S, Rudolph, M.G.
登録日2016-11-10
公開日2017-06-21
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献Crystal Structure of a Factor VIIa complex
To be published
5P9R
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BU of 5p9r by Molmil
humanized rat COMT in complex with 5-chloro-6-(4-fluorophenyl)-8-hydroxy-3H-quinazolin-4-one
分子名称: 5-chloranyl-6-(4-fluorophenyl)-8-oxidanyl-3~{H}-quinazolin-4-one, CHLORIDE ION, Catechol O-methyltransferase, ...
著者Ehler, A, Jakob-Roetne, R, Rudolph, M.G.
登録日2016-10-19
公開日2017-11-22
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Crystal Structure of a COMT complex
To be published
5PAS
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BU of 5pas by Molmil
Crystal Structure of Factor VIIa in complex with (2S)-2-hydroxy-N-[[3-[5-hydroxy-4-(1H-pyrrolo[3,2-c]pyridin-2-yl)pyrazol-1-yl]phenyl]methyl]-3-phenylpropanamide
分子名称: (2S)-2-hydroxy-N-[[3-[5-hydroxy-4-(1H-pyrrolo[3,2-c]pyridin-2-yl)pyrazol-1-yl]phenyl]methyl]-3-phenylpropanamide, CALCIUM ION, CHLORIDE ION, ...
著者Stihle, M, Mayweg, A, Roever, S, Rudolph, M.G.
登録日2016-11-10
公開日2017-06-21
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (1.48 Å)
主引用文献Crystal Structure of a Factor VIIa complex
To be published
5PA4
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BU of 5pa4 by Molmil
humanized rat COMT in complex with 6-(4-fluorophenyl)-8-hydroxy-3H-quinazolin-4-one
分子名称: 6-(4-fluorophenyl)-8-oxidanyl-3~{H}-quinazolin-4-one, Catechol O-methyltransferase, MAGNESIUM ION, ...
著者Ehler, A, Lerner, C, Rudolph, M.G.
登録日2016-10-19
公開日2017-11-22
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (1.99 Å)
主引用文献Crystal Structure of a COMT complex
To be published
5PAF
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BU of 5paf by Molmil
Crystal Structure of Factor VIIa in complex with N-(2-amino-1H-benzimidazol-5-yl)-2-[3-[(2-amino-2-oxoethyl)-methylsulfonylamino]-5-chlorophenyl]acetamide;2,2,2-trifluoroacetic acid
分子名称: CALCIUM ION, CHLORIDE ION, Coagulation factor VII heavy chain, ...
著者Stihle, M, Mayweg, A, Roever, S, Rudolph, M.G.
登録日2016-11-10
公開日2017-06-21
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献Crystal Structure of a Factor VIIa complex
To be published
5PAX
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BU of 5pax by Molmil
Crystal Structure of Factor VIIa in complex with 1-(2,6-difluorophenyl)-3-[[3-[5-hydroxy-4-(1H-pyrrolo[3,2-c]pyridin-2-yl)pyrazol-1-yl]phenyl]methyl]urea
分子名称: 1-(2,6-difluorophenyl)-3-[[3-[5-hydroxy-4-(1H-pyrrolo[3,2-c]pyridin-2-yl)pyrazol-1-yl]phenyl]methyl]urea, CALCIUM ION, CHLORIDE ION, ...
著者Stihle, M, Mayweg, A, Roever, S, Rudolph, M.G.
登録日2016-11-10
公開日2017-06-21
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (1.36 Å)
主引用文献Crystal Structure of a Factor VIIa complex
To be published
5PB2
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BU of 5pb2 by Molmil
Crystal Structure of Factor VIIa in complex with 2-phenyl-4-(1H-pyrrolo[3,2-c]pyridin-2-yl)pyrazol-3-ol
分子名称: 1-phenyl-4-(1H-pyrrolo[3,2-c]pyridin-2-yl)-1H-pyrazol-5-ol, CALCIUM ION, CHLORIDE ION, ...
著者Stihle, M, Mayweg, A, Roever, S, Rudolph, M.G.
登録日2016-11-16
公開日2017-06-21
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (1.45 Å)
主引用文献Crystal Structure of a Factor VIIa complex
To be published
5P9P
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BU of 5p9p by Molmil
humanized rat COMT in complex with 5,6-bis(4-fluorophenyl)-8-hydroxy-3H-quinazolin-4-one
分子名称: (4S,5S)-1,2-DITHIANE-4,5-DIOL, 2-[N-CYCLOHEXYLAMINO]ETHANE SULFONIC ACID, 5,6-bis(4-fluorophenyl)-8-oxidanyl-3~{H}-quinazolin-4-one, ...
著者Ehler, A, Jakob-Roetne, R, Rudolph, M.G.
登録日2016-10-19
公開日2017-11-22
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (1.12 Å)
主引用文献Crystal Structure of a COMT complex
To be published
5PA7
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BU of 5pa7 by Molmil
humanized rat COMT in complex with 6-bromo-3-chloroquinolin-8-ol
分子名称: 6-bromanyl-3-chloranyl-quinolin-8-ol, Catechol O-methyltransferase, MAGNESIUM ION, ...
著者Ehler, A, Lerner, C, Rudolph, M.G.
登録日2016-10-19
公開日2017-11-22
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (2.12 Å)
主引用文献Crystal Structure of a COMT complex
To be published
5PAT
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BU of 5pat by Molmil
Crystal Structure of Factor VIIa in complex with N-(2-amino-1H-benzimidazol-5-yl)-2-(3-chlorophenyl)acetamide
分子名称: Coagulation factor VII heavy chain, Coagulation factor VII light chain, N-(2-amino-1H-benzimidazol-5-yl)-2-(3-chlorophenyl)acetamide, ...
著者Stihle, M, Mayweg, A, Roever, S, Rudolph, M.G.
登録日2016-11-10
公開日2017-06-21
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Crystal Structure of a Factor VIIa complex
To be published
5P9C
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BU of 5p9c by Molmil
rat catechol O-methyltransferase in complex with 5-(4-fluorophenyl)-2,3-dihydroxy-N-(5-pyrrolo[3,2-c]pyridin-1-ylpentyl)benzamide at 1.70A
分子名称: (4S,5S)-1,2-DITHIANE-4,5-DIOL, 5-(4-fluorophenyl)-2,3-dihydroxy-N-(5-pyrrolo[3,2-c]pyridin-1-ylpentyl)benzamide, Catechol O-methyltransferase, ...
著者Ehler, A, Lerner, C, Rudolph, M.G.
登録日2016-08-30
公開日2017-08-30
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Crystal Structure of a COMT complex
To be published
5P9O
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BU of 5p9o by Molmil
humanized rat COMT in complex with 7-fluoro-5,6-bis(4-fluorophenyl)-8-hydroxy-3H-quinazolin-4-one
分子名称: 2-[N-CYCLOHEXYLAMINO]ETHANE SULFONIC ACID, 7-fluoranyl-5,6-bis(4-fluorophenyl)-8-oxidanyl-3~{H}-quinazolin-4-one, CHLORIDE ION, ...
著者Ehler, A, Lerner, C, Rudolph, M.G.
登録日2016-10-19
公開日2017-11-22
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (1.1 Å)
主引用文献Crystal Structure of a COMT complex
To be published
5PA5
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BU of 5pa5 by Molmil
humanized rat COMT in complex with 6-(2,4-dimethyl-1,3-thiazol-5-yl)-8-hydroxy-3H-quinazolin-4-one
分子名称: (4S,5S)-1,2-DITHIANE-4,5-DIOL, 6-(2,4-dimethyl-1,3-thiazol-5-yl)-8-oxidanyl-3~{H}-quinazolin-4-one, ACETATE ION, ...
著者Ehler, A, Lerner, C, Rudolph, M.G.
登録日2016-10-19
公開日2017-11-22
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (1.63 Å)
主引用文献Crystal Structure of a COMT complex
To be published
5PAG
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BU of 5pag by Molmil
Crystal Structure of Factor VIIa in complex with (2R)-2-hydroxy-N-[[3-[5-hydroxy-4-(1H-pyrrolo[3,2-c]pyridin-2-yl)pyrazol-1-yl]phenyl]methyl]-3-methylbutanamide;hydrobromide
分子名称: (2R)-2-hydroxy-N-[[3-[5-hydroxy-4-(1H-pyrrolo[3,2-c]pyridin-2-yl)pyrazol-1-yl]phenyl]methyl]-3-methylbutanamide, CALCIUM ION, CHLORIDE ION, ...
著者Stihle, M, Mayweg, A, Roever, S, Rudolph, M.G.
登録日2016-11-10
公開日2017-06-21
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (1.36 Å)
主引用文献Crystal Structure of a Factor VIIa complex
To be published
5PAY
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BU of 5pay by Molmil
Crystal Structure of Factor VIIa in complex with 1-[[3-[5-hydroxy-4-(1H-pyrrolo[3,2-c]pyridin-2-yl)pyrazol-1-yl]phenyl]methyl]-3-phenylurea
分子名称: 1-[[3-[5-hydroxy-4-(1H-pyrrolo[3,2-c]pyridin-2-yl)pyrazol-1-yl]phenyl]methyl]-3-phenylurea, CALCIUM ION, CHLORIDE ION, ...
著者Stihle, M, Mayweg, A, Roever, S, Rudolph, M.G.
登録日2016-11-10
公開日2017-06-21
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (1.66 Å)
主引用文献Crystal Structure of a Factor VIIa complex
To be published
7FUD
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BU of 7fud by Molmil
Crystal Structure of human cyclic GMP-AMP synthase in complex with 5-benzyl-2-[[2-chloro-5-(1-methylpyrazol-3-yl)phenyl]methylamino]-4H-[1,2,4]triazolo[1,5-a]pyrimidin-7-one
分子名称: (8S)-5-benzyl-2-({[(5P)-2-chloro-5-(1-methyl-1H-pyrazol-3-yl)phenyl]methyl}amino)[1,2,4]triazolo[1,5-a]pyrimidin-7(4H)-one, Cyclic GMP-AMP synthase, ZINC ION
著者Leibrock, L, Benz, J, Groebke-Zbinden, K, Rudolph, M.G.
登録日2023-02-08
公開日2024-02-21
実験手法X-RAY DIFFRACTION (2.026 Å)
主引用文献Crystal Structure of a human cyclic GMP-AMP synthase complex
To be published
7FVT
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BU of 7fvt by Molmil
Crystal Structure of S. aureus gyrase in complex with 6-[5-[2-[(4-chloro-2,3-dihydro-1H-inden-2-yl)methylamino]ethyl]-2-oxo-1,3-oxazolidin-3-yl]-4H-pyrido[3,2-b][1,4]oxazin-3-one
分子名称: 6-{(5R)-5-[2-({[(2R)-4-chloro-2,3-dihydro-1H-inden-2-yl]methyl}amino)ethyl]-2-oxo-1,3-oxazolidin-3-yl}-2H-pyrido[3,2-b][1,4]oxazin-3(4H)-one, CHLORIDE ION, DNA (5'-D(*AP*GP*CP*CP*GP*TP*AP*GP*GP*GP*CP*CP*CP*TP*AP*CP*GP*GP*CP*T)-3'), ...
著者Xu, B, Benz, J, Cumming, J.G, Rudolph, M.G.
登録日2023-04-18
公開日2023-06-28
最終更新日2023-08-16
実験手法X-RAY DIFFRACTION (2.081 Å)
主引用文献Discovery of a Series of Indane-Containing NBTIs with Activity against Multidrug-Resistant Gram-Negative Pathogens.
Acs Med.Chem.Lett., 14, 2023
7FTW
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BU of 7ftw by Molmil
Crystal Structure of human cyclic GMP-AMP synthase in complex with 5-bromo-2-hydroxy-N-[[3-(1-methylpyrazol-4-yl)phenyl]methyl]benzamide
分子名称: 5-bromo-2-hydroxy-N-{[(3M)-3-(1-methyl-1H-pyrazol-4-yl)phenyl]methyl}benzamide, Cyclic GMP-AMP synthase, ZINC ION
著者Leibrock, L, Benz, J, Groebke-Zbinden, K, Rudolph, M.G.
登録日2023-02-08
公開日2024-02-21
実験手法X-RAY DIFFRACTION (2.208 Å)
主引用文献Crystal Structure of a human cyclic GMP-AMP synthase complex
To be published
7FVS
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BU of 7fvs by Molmil
Crystal Structure of S. aureus gyrase in complex with 4-[[1-[(1-chloro-6,7-dihydro-5H-cyclopenta[c]pyridin-6-yl)methyl]azetidin-3-yl]methylamino]-6-fluorochromen-2-one
分子名称: 4-{[(1-{[(6R)-1-chloro-6,7-dihydro-5H-cyclopenta[c]pyridin-6-yl]methyl}azetidin-3-yl)methyl]amino}-6-fluoro-2H-1-benzopyran-2-one, ACETATE ION, CHLORIDE ION, ...
著者Xu, B, Benz, J, Cumming, J.G, Kreis, L, Rudolph, M.G.
登録日2023-04-18
公開日2023-06-28
最終更新日2023-08-16
実験手法X-RAY DIFFRACTION (2.16 Å)
主引用文献Discovery of a Series of Indane-Containing NBTIs with Activity against Multidrug-Resistant Gram-Negative Pathogens.
Acs Med.Chem.Lett., 14, 2023
7FSE
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BU of 7fse by Molmil
Crystal Structure of T. maritima reverse gyrase with a minimal latch
分子名称: CHLORIDE ION, DODECAETHYLENE GLYCOL, Reverse gyrase, ...
著者Rasche, R, Kummel, D, Rudolph, M.G, Klostermeier, D.
登録日2023-01-04
公開日2023-05-10
最終更新日2024-05-22
実験手法X-RAY DIFFRACTION (2.89 Å)
主引用文献Structure of reverse gyrase with a minimal latch that supports ATP-dependent positive supercoiling without specific interactions with the topoisomerase domain.
Acta Crystallogr D Struct Biol, 79, 2023

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件を2024-06-19に公開中

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