7VME
 
 | | Crystal structure of a hydrolase in apo form 2 | | 分子名称: | CALCIUM ION, hydrolase | | 著者 | Wu, P, Zhao, Y.P, Li, Z.S, Ingrid, M.C, Lara, P, Gao, J, Han, X, Li, Q, Basak, O, Liu, W.D, Wei, R. | | 登録日 | 2021-10-08 | | 公開日 | 2022-10-12 | | 最終更新日 | 2024-11-20 | | 実験手法 | X-RAY DIFFRACTION (1.78 Å) | | 主引用文献 | Crystal structure of a hydrolase in apo form 2
to be published
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6JBX
 | | Crystal structure of Streptococcus pneumoniae FabT in complex with DNA | | 分子名称: | DNA (5'-D(*AP*AP*TP*AP*GP*TP*TP*TP*GP*AP*CP*TP*GP*TP*CP*AP*AP*AP*TP*TP*AP*TP*G)-3'), DNA (5'-D(*CP*AP*TP*AP*AP*TP*TP*TP*GP*AP*CP*AP*GP*TP*CP*AP*AP*AP*CP*TP*AP*TP*T)-3'), Fatty acid biosynthesis transcriptional regulator, ... | | 著者 | Zuo, G, Chen, Z.P, Li, Q, Zhou, C.Z. | | 登録日 | 2019-01-27 | | 公開日 | 2019-07-24 | | 最終更新日 | 2024-03-27 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Structural insights into repression of the Pneumococcal fatty acid synthesis pathway by repressor FabT and co-repressor acyl-ACP.
Febs Lett., 593, 2019
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6JY5
 | | Structure of CsoS4B from Halothiobacillus neapolitanus | | 分子名称: | Unidentified carboxysome polypeptide | | 著者 | Zhao, Y.Y, Jiang, Y.L, Chen, Y, Zhou, C.Z, Li, Q. | | 登録日 | 2019-04-26 | | 公開日 | 2019-06-26 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (2.15 Å) | | 主引用文献 | Crystal structure of pentameric shell protein CsoS4B of Halothiobacillus neapolitanus alpha-carboxysome.
Biochem.Biophys.Res.Commun., 515, 2019
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8IJT
 | | crystal structure of Hyp N135A mutant from Hypoxylon sp. E7406B | | 分子名称: | Terpene synthase | | 著者 | Gao, J, Su, L.Q, Li, Q, Han, X, Wei, H.L, Dai, Z.J, Liu, W.D. | | 登録日 | 2023-02-28 | | 公開日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (2.56 Å) | | 主引用文献 | crystal structure of Hyp N135A mutant from Hypoxylon sp. E7406B
to be published
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8II9
 | | crystal structure of Hyp mutant from Hypoxylon sp. E7406B | | 分子名称: | Terpene synthase | | 著者 | Gao, J, Liu, W.D, Li, Q, Han, X, Wei, H.L, Dai, Z.J, Su, L.Q. | | 登録日 | 2023-02-24 | | 公開日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (2.17 Å) | | 主引用文献 | crystal structure of Hyp
to be published
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8JUL
 | | Cryo-EM structure of SIDT1 in complex with phosphatidic acid | | 分子名称: | 1,2-DILAUROYL-SN-GLYCERO-3-PHOSPHATE, SID1 transmembrane family member 1, ZINC ION | | 著者 | Sun, C.R, Xu, D, Li, Q, Zhou, C.Z, Chen, Y. | | 登録日 | 2023-06-26 | | 公開日 | 2023-11-15 | | 最終更新日 | 2024-10-23 | | 実験手法 | ELECTRON MICROSCOPY (2.92 Å) | | 主引用文献 | Human SIDT1 mediates dsRNA uptake via its phospholipase activity.
Cell Res., 34, 2024
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8JUN
 | | Cryo-EM structure of SIDT1 E555Q mutant | | 分子名称: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, SID1 transmembrane family member 1, ZINC ION | | 著者 | Sun, C.R, Xu, D, Li, Q, Zhou, C.Z, Chen, Y. | | 登録日 | 2023-06-26 | | 公開日 | 2023-11-15 | | 最終更新日 | 2024-11-06 | | 実験手法 | ELECTRON MICROSCOPY (2.38 Å) | | 主引用文献 | Human SIDT1 mediates dsRNA uptake via its phospholipase activity.
Cell Res., 34, 2024
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8IQ6
 | | Cryo-EM structure of Latanoprost-bound prostaglandin-F2-alpha receptor-miniGq-Nb35 complex | | 分子名称: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, ... | | 著者 | Lv, X, Gao, K, Nie, J, Zhang, X, Zhang, S, Ren, Y, Li, Q, Huang, J, Liu, L, Zhang, X, Sun, X, Zhang, W, Liu, X. | | 登録日 | 2023-03-15 | | 公開日 | 2024-01-31 | | 最終更新日 | 2024-11-06 | | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | | 主引用文献 | Structures of human prostaglandin F 2 alpha receptor reveal the mechanism of ligand and G protein selectivity.
Nat Commun, 14, 2023
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8IQ4
 | | Cryo-EM structure of Carboprost-bound prostaglandin-F2-alpha receptor-miniGq-Nb35 complex | | 分子名称: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, ... | | 著者 | Lv, X, Gao, K, Nie, J, Zhang, X, Zhang, S, Ren, Y, Li, Q, Huang, J, Liu, L, Zhang, X, Sun, X, Zhang, W, Liu, X. | | 登録日 | 2023-03-15 | | 公開日 | 2024-01-31 | | 最終更新日 | 2024-10-16 | | 実験手法 | ELECTRON MICROSCOPY (2.7 Å) | | 主引用文献 | Structures of human prostaglandin F 2 alpha receptor reveal the mechanism of ligand and G protein selectivity.
Nat Commun, 14, 2023
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8KEE
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8KEA
 | | Cyanophage A-1(L) baseplate-initiators | | 分子名称: | baseplate gp16, central spike, hub, ... | | 著者 | Yu, R.C, Li, Q, Zhou, C.Z. | | 登録日 | 2023-08-11 | | 公開日 | 2024-04-10 | | 実験手法 | ELECTRON MICROSCOPY (3.44 Å) | | 主引用文献 | Structure of the intact tail machine of Anabaena myophage A-1(L).
Nat Commun, 15, 2024
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8KE9
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8J3Z
 | | Cryo-EM structure of ATP-U46619-bound ABCC4 | | 分子名称: | (5Z)-7-{(1R,4S,5S,6R)-6-[(1E,3S)-3-hydroxyoct-1-en-1-yl]-2-oxabicyclo[2.2.1]hept-5-yl}hept-5-enoic acid, ADENOSINE-5'-TRIPHOSPHATE, ATP-binding cassette sub-family C member 4, ... | | 著者 | Chen, Y, Wang, L, Hou, W.T, Zhou, C.Z, Chen, Y, Li, Q. | | 登録日 | 2023-04-18 | | 公開日 | 2023-05-24 | | 最終更新日 | 2024-07-03 | | 実験手法 | ELECTRON MICROSCOPY (3.17 Å) | | 主引用文献 | Cryo-EM structure ofABCC4
Nat Cardiovasc Res, 2023
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8J3W
 | | Cryo-EM structure of aspirin-bound ABCC4 | | 分子名称: | 2-(ACETYLOXY)BENZOIC ACID, ATP-binding cassette sub-family C member 4 | | 著者 | Chen, Y, Wang, L, Hou, W.T, Zhou, C.Z, Chen, Y, Li, Q. | | 登録日 | 2023-04-18 | | 公開日 | 2023-05-24 | | 最終更新日 | 2024-07-03 | | 実験手法 | ELECTRON MICROSCOPY (3.07 Å) | | 主引用文献 | Cryo-EM structure ofABCC4
Nat Cardiovasc Res, 2023
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8KEG
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8KEF
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8KEC
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7F38
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9J0K
 | | An agonist(compound 14e)of Thyroid Hormone Receptor B | | 分子名称: | 2-[[7-[3-(aminomethyl)phenoxy]-1-methoxy-4-oxidanyl-isoquinolin-3-yl]carbonylamino]ethanoic acid, Nuclear receptor coactivator 2, Thyroid hormone receptor beta | | 著者 | Yao, B, Li, Y. | | 登録日 | 2024-08-02 | | 公開日 | 2025-07-02 | | 実験手法 | X-RAY DIFFRACTION (2.698 Å) | | 主引用文献 | Discovery of a Potent, Selective, and Multiple His435 Mutation-Sensitive Thyroid Hormone Receptor beta Agonist.
J.Med.Chem., 2025
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9IX5
 | | An agonist(compound 15n) of Thyroid Hormone Receptor B | | 分子名称: | 2-[(1-methoxy-7-naphthalen-2-yloxy-4-oxidanyl-isoquinolin-3-yl)carbonylamino]ethanoic acid, Nuclear receptor coactivator 2, Thyroid hormone receptor beta | | 著者 | Yao, B, Li, Y. | | 登録日 | 2024-07-26 | | 公開日 | 2025-07-02 | | 実験手法 | X-RAY DIFFRACTION (2.65 Å) | | 主引用文献 | Discovery of a Potent, Selective, and Multiple His435 Mutation-Sensitive Thyroid Hormone Receptor beta Agonist.
J.Med.Chem., 2025
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9JS5
 | | Crystal structure of the ASFV-derived histone-like protein pA104R | | 分子名称: | 1,2-ETHANEDIOL, SULFATE ION, Viral histone-like protein | | 著者 | Li, Q, Shao, H, Yi, D, Cen, S. | | 登録日 | 2024-09-30 | | 公開日 | 2025-04-30 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Thonningianin A disrupts pA104R-DNA binding and inhibits African swine fever virus replication.
Emerg Microbes Infect, 14, 2025
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2I1K
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7RSU
 | | TNA polymerase, n+2 product | | 分子名称: | DNA polymerase, Primer, Template | | 著者 | Maola, V, Chaput, J, Chim, N. | | 登録日 | 2021-08-11 | | 公開日 | 2021-10-27 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Synthesis and Polymerase Recognition of Threose Nucleic Acid Triphosphates Equipped with Diverse Chemical Functionalities.
J.Am.Chem.Soc., 143, 2021
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6CDY
 | | Crystal structure of TEAD complexed with its inhibitor | | 分子名称: | 2-[(4H-1,2,4-triazol-3-yl)sulfanyl]-N-{4-[(3s,5s,7s)-tricyclo[3.3.1.1~3,7~]decan-1-yl]phenyl}acetamide, Transcriptional enhancer factor TEF-4 | | 著者 | LIU, S, HAN, X, LUO, X. | | 登録日 | 2018-02-09 | | 公開日 | 2020-07-01 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (2.32 Å) | | 主引用文献 | Lats1/2 Sustain Intestinal Stem Cells and Wnt Activation through TEAD-Dependent and Independent Transcription.
Cell Stem Cell, 26, 2020
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2F7E
 | | PKA complexed with (S)-2-(1H-Indol-3-yl)-1-(5-isoquinolin-6-yl-pyridin-3-yloxymethyl-etylamine | | 分子名称: | (1S)-2-(1H-INDOL-3-YL)-1-{[(5-ISOQUINOLIN-6-YLPYRIDIN-3-YL)OXY]METHYL}ETHYLAMINE, PKI inhibitory peptide, cAMP-dependent protein kinase, ... | | 著者 | Stoll, V.S. | | 登録日 | 2005-11-30 | | 公開日 | 2006-06-27 | | 最終更新日 | 2024-02-14 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Synthesis and structure-activity relationship of 3,4'-bispyridinylethylenes: discovery of a potent 3-isoquinolinylpyridine inhibitor of protein kinase B (PKB/Akt) for the treatment of cancer.
Bioorg.Med.Chem.Lett., 16, 2006
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