5XK9
| Crystal structure of Isosesquilavandulyl Diphosphate Synthase from Streptomyces sp. strain CNH-189 in complex with GSPP and DMAPP | 分子名称: | DIMETHYLALLYL DIPHOSPHATE, GERANYL S-THIOLODIPHOSPHATE, MAGNESIUM ION, ... | 著者 | Ko, T.P, Guo, R.T, Liu, W, Chen, C.C, Gao, J. | 登録日 | 2017-05-05 | 公開日 | 2018-01-10 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.137 Å) | 主引用文献 | "Head-to-Middle" and "Head-to-Tail" cis-Prenyl Transferases: Structure of Isosesquilavandulyl Diphosphate Synthase. Angew. Chem. Int. Ed. Engl., 57, 2018
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5W8I
| Crystal Structure of Lactate Dehydrogenase A in complex with inhibitor compound 23 and Zinc | 分子名称: | 2-[3-(3,4-difluorophenyl)-5-hydroxy-1H-pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid, CITRIC ACID, DIMETHYL SULFOXIDE, ... | 著者 | Lukacs, C.M, Abendroth, J. | 登録日 | 2017-06-21 | 公開日 | 2018-01-17 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | 主引用文献 | Discovery and Optimization of Potent, Cell-Active Pyrazole-Based Inhibitors of Lactate Dehydrogenase (LDH). J. Med. Chem., 60, 2017
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5W8L
| Crystal Structure of Lactate Dehydrogenase A in complex with inhibitor compound 59 and NADH | 分子名称: | 1,2-ETHANEDIOL, 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, 2-{3-([1,1'-biphenyl]-3-yl)-5-(cyclopropylmethyl)-4-[(4-sulfamoylphenyl)methyl]-1H-pyrazol-1-yl}-1,3-thiazole-4-carboxylic acid, ... | 著者 | Davies, D.R, Dranow, D.M. | 登録日 | 2017-06-21 | 公開日 | 2018-01-17 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | 主引用文献 | Discovery and Optimization of Potent, Cell-Active Pyrazole-Based Inhibitors of Lactate Dehydrogenase (LDH). J. Med. Chem., 60, 2017
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5XK3
| Crystal structure of apo form Isosesquilavandulyl Diphosphate Synthase from Streptomyces sp. strain CNH-189 | 分子名称: | SULFATE ION, Undecaprenyl diphosphate synthase | 著者 | Ko, T.P, Guo, R.T, Liu, W, Chen, C.C, Gao, J. | 登録日 | 2017-05-05 | 公開日 | 2018-01-10 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (1.996 Å) | 主引用文献 | "Head-to-Middle" and "Head-to-Tail" cis-Prenyl Transferases: Structure of Isosesquilavandulyl Diphosphate Synthase. Angew. Chem. Int. Ed. Engl., 57, 2018
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8JJC
| Tubulin-Y62 | 分子名称: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 4-(6,7-dimethoxy-3,4-dihydro-1~{H}-isoquinolin-2-yl)-6-(3-methoxyphenyl)pyrimidin-2-amine, CALCIUM ION, ... | 著者 | Yang, J. | 登録日 | 2023-05-30 | 公開日 | 2024-03-27 | 実験手法 | X-RAY DIFFRACTION (2.76 Å) | 主引用文献 | Structure-based design and synthesis of BML284 derivatives: A novel class of colchicine-site noncovalent tubulin degradation agents. Eur.J.Med.Chem., 268, 2024
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8JJB
| Crystal structure of T2R-TTL-Y61 complex | 分子名称: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CALCIUM ION, CHLORIDE ION, ... | 著者 | Yang, J. | 登録日 | 2023-05-30 | 公開日 | 2024-03-27 | 実験手法 | X-RAY DIFFRACTION (2.68 Å) | 主引用文献 | Structure-based design and synthesis of BML284 derivatives: A novel class of colchicine-site noncovalent tubulin degradation agents. Eur.J.Med.Chem., 268, 2024
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8JNX
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9FKZ
| Discovery of a Series of Covalent, Cell Active Bfl-1 Inhibitors | 分子名称: | Bcl-2-related protein A1, ~{N}-[4-[(1~{R},3~{R})-3-azanylcyclopentyl]oxyphenyl]-~{N}-[(4-chlorophenyl)methyl]prop-2-enamide | 著者 | Hargreaves, D. | 登録日 | 2024-06-04 | 公開日 | 2024-10-02 | 最終更新日 | 2024-10-09 | 実験手法 | X-RAY DIFFRACTION (1.684 Å) | 主引用文献 | Structure-Based Optimization of a Series of Covalent, Cell Active Bfl-1 Inhibitors. J.Med.Chem., 67, 2024
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9FL0
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9FKY
| Discovery of a Series of Covalent, Cell Active Bfl-1 Inhibitors | 分子名称: | Bcl-2-related protein A1, ~{N}-[4-[(1~{R},3~{R})-3-azanylcyclopentyl]oxyphenyl]-~{N}-[(1~{S})-1-[3-cyano-4-(trifluoromethyl)phenyl]ethyl]propanamide | 著者 | Hargreaves, D. | 登録日 | 2024-06-04 | 公開日 | 2024-10-02 | 最終更新日 | 2024-10-09 | 実験手法 | X-RAY DIFFRACTION (1.557 Å) | 主引用文献 | Structure-Based Optimization of a Series of Covalent, Cell Active Bfl-1 Inhibitors. J.Med.Chem., 67, 2024
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7C29
| Esterase CrmE10 mutant-D178A | 分子名称: | 1,2-ETHANEDIOL, ACETATE ION, CALCIUM ION, ... | 著者 | Li, Z, Li, J. | 登録日 | 2020-05-07 | 公開日 | 2020-05-20 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.18 Å) | 主引用文献 | Structure-guided protein engineering increases enzymatic activities of the SGNH family esterases. Biotechnol Biofuels, 13, 2020
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7C82
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7C84
| Esterase AlinE4 mutant, D162A | 分子名称: | ACETATE ION, CADMIUM ION, GLYCEROL, ... | 著者 | Li, Z, Li, J. | 登録日 | 2020-05-28 | 公開日 | 2020-07-08 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (1.552 Å) | 主引用文献 | Structure-guided protein engineering increases enzymatic activities of the SGNH family esterases. Biotechnol Biofuels, 13, 2020
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7C85
| Esterase AlinE4 mutant-S13A | 分子名称: | ACETATE ION, CADMIUM ION, SGNH-hydrolase family esterase | 著者 | Li, Z, Li, J. | 登録日 | 2020-05-28 | 公開日 | 2020-07-08 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | 主引用文献 | Structure-guided protein engineering increases enzymatic activities of the SGNH family esterases. Biotechnol Biofuels, 13, 2020
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7DGW
| De novo designed protein H4A2S | 分子名称: | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, de novo designed protein H4A2S | 著者 | Xu, Y, Liao, S, Chen, Q, Liu, H. | 登録日 | 2020-11-12 | 公開日 | 2021-11-24 | 最終更新日 | 2024-05-29 | 実験手法 | X-RAY DIFFRACTION (1.35 Å) | 主引用文献 | A backbone-centred energy function of neural networks for protein design. Nature, 602, 2022
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7DGU
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7DKK
| De novo design protein XM2H | 分子名称: | De novo design protein XM2H | 著者 | Bin, H. | 登録日 | 2020-11-24 | 公開日 | 2021-12-08 | 最終更新日 | 2024-05-29 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | A backbone-centred energy function of neural networks for protein design. Nature, 602, 2022
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7DKO
| De novo design protein AM2M | 分子名称: | de novo designed protein AM2M | 著者 | Bin, H. | 登録日 | 2020-11-25 | 公開日 | 2021-12-08 | 最終更新日 | 2024-05-29 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | A backbone-centred energy function of neural networks for protein design. Nature, 602, 2022
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7DMF
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7DGY
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7C23
| Crystal structure of CrmE10, a SGNH-hydrolase family esterase | 分子名称: | 1,2-ETHANEDIOL, ACETATE ION, CALCIUM ION, ... | 著者 | Li, Z, Li, J. | 登録日 | 2020-05-07 | 公開日 | 2020-05-20 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Structure-guided protein engineering increases enzymatic activities of the SGNH family esterases. Biotechnol Biofuels, 13, 2020
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7Y4S
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7YJS
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7YJR
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7YJQ
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