1HTT
 
 | | HISTIDYL-TRNA SYNTHETASE | | 分子名称: | ADENOSINE MONOPHOSPHATE, HISTIDINE, HISTIDYL-TRNA SYNTHETASE | | 著者 | Arnez, J.G, Harris, D.C, Mitschler, A, Rees, B, Francklyn, C.S, Moras, D. | | 登録日 | 1996-03-09 | | 公開日 | 1997-01-27 | | 最終更新日 | 2024-02-07 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | Crystal structure of histidyl-tRNA synthetase from Escherichia coli complexed with histidyl-adenylate.
EMBO J., 14, 1995
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7NH3
 | | Nematocida Huwe1 in open conformation. | | 分子名称: | E3 ubiquitin-protein ligase HUWE1 | | 著者 | Petrova, O, Grishkovskaya, I, Grabarczyk, D.B, Kessler, D, Haselbach, D, Clausen, T. | | 登録日 | 2021-02-09 | | 公開日 | 2022-03-02 | | 最終更新日 | 2025-07-09 | | 実験手法 | ELECTRON MICROSCOPY (6.37 Å) | | 主引用文献 | Crystal structure of HUWE1: One ring to ubiquitinate them all
To Be Published
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5QOI
 | | PanDDA analysis group deposition -- Crystal Structure of DCP2 (NUDT20) in complex with FMOPL000213a | | 分子名称: | 1,2-ETHANEDIOL, ACETATE ION, DCP2 (NUDT20), ... | | 著者 | Nelson, E.R, Velupillai, S, Talon, R, Collins, P.M, Krojer, T, Wang, D, Brandao-Neto, J, Douangamath, A, Burgess-Brown, N, Arrowsmith, C.H, Bountra, C, Huber, K, von Delft, F. | | 登録日 | 2019-02-22 | | 公開日 | 2019-05-08 | | 最終更新日 | 2024-03-06 | | 実験手法 | X-RAY DIFFRACTION (1.99 Å) | | 主引用文献 | PanDDA analysis group deposition
To Be Published
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5QP9
 | | PanDDA analysis group deposition -- Crystal Structure of DCP2 (NUDT20) in complex with Z100435060 | | 分子名称: | 1,2-ETHANEDIOL, ACETATE ION, DCP2 (NUDT20), ... | | 著者 | Nelson, E.R, Velupillai, S, Talon, R, Collins, P.M, Krojer, T, Wang, D, Brandao-Neto, J, Douangamath, A, Burgess-Brown, N, Arrowsmith, C.H, Bountra, C, Huber, K, von Delft, F. | | 登録日 | 2019-02-22 | | 公開日 | 2019-05-08 | | 最終更新日 | 2024-03-06 | | 実験手法 | X-RAY DIFFRACTION (1.72 Å) | | 主引用文献 | PanDDA analysis group deposition
To Be Published
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8XXS
 | | Crystal structure of PDE4D catalytic domain complexed with L11 | | 分子名称: | 2-[4-[bis(fluoranyl)methoxy]-3-(cyclopropylmethoxy)phenyl]-1-benzofuran-6-ol, MAGNESIUM ION, ZINC ION, ... | | 著者 | Wu, D, Huang, Y.-Y, Luo, H.-B. | | 登録日 | 2024-01-19 | | 公開日 | 2025-01-22 | | 最終更新日 | 2025-03-12 | | 実験手法 | X-RAY DIFFRACTION (2.10000944 Å) | | 主引用文献 | 5-hydroxymethylcytosine features of portal venous blood predict metachronous liver metastases of colorectal cancer and reveal phosphodiesterase 4 as a therapeutic target.
Clin Transl Med, 15, 2025
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9CYB
 | | SARS-CoV-2 PLpro in complex with inhibitor WEHI-P1 | | 分子名称: | Papain-like protease, SUCCINIC ACID, [(3R)-1-cyclopentylpiperidin-3-yl](6-methoxynaphthalen-2-yl)methanone | | 著者 | Calleja, D.J, Lechtenberg, B.C, Kuchel, N.W, Devine, S.M, Bader, S.M, Doerflinger, M, Mitchell, J.P, Lessene, G, Komander, D. | | 登録日 | 2024-08-01 | | 公開日 | 2025-04-09 | | 最終更新日 | 2025-04-16 | | 実験手法 | X-RAY DIFFRACTION (1.98 Å) | | 主引用文献 | A novel PLpro inhibitor improves outcomes in a pre-clinical model of long COVID.
Nat Commun, 16, 2025
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9CYD
 | | SARS-CoV-2 PLpro in complex with inhibitor WEHI-P4 | | 分子名称: | (1S,4s)-4-{(3R)-3-[(E)-(methoxyimino)(6-methoxynaphthalen-2-yl)methyl]piperidin-1-yl}cyclohexan-1-ol, CHLORIDE ION, Papain-like protease, ... | | 著者 | Calleja, D.J, Lechtenberg, B.C, Kuchel, N.W, Devine, S.M, Bader, S.M, Doerflinger, M, Mitchell, J.P, Lessene, G, Komander, D. | | 登録日 | 2024-08-02 | | 公開日 | 2025-04-09 | | 最終更新日 | 2025-04-16 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | A novel PLpro inhibitor improves outcomes in a pre-clinical model of long COVID.
Nat Commun, 16, 2025
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9CYK
 | | SARS-CoV-2 PLpro in complex with inhibitor WEHI-P24 | | 分子名称: | ACETIC ACID, GLYCEROL, Papain-like protease, ... | | 著者 | Calleja, D.J, Lechtenberg, B.C, Kuchel, N.W, Devine, S.M, Bader, S.M, Doerflinger, M, Mitchell, J.P, Lessene, G, Komander, D. | | 登録日 | 2024-08-02 | | 公開日 | 2025-04-09 | | 最終更新日 | 2025-04-16 | | 実験手法 | X-RAY DIFFRACTION (1.88 Å) | | 主引用文献 | A novel PLpro inhibitor improves outcomes in a pre-clinical model of long COVID.
Nat Commun, 16, 2025
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5QOS
 | | PanDDA analysis group deposition -- Crystal Structure of DCP2 (NUDT20) in complex with Z1187701032 | | 分子名称: | (3S)-N-(pyrimidin-2-yl)azepan-3-amine, 1,2-ETHANEDIOL, ACETATE ION, ... | | 著者 | Nelson, E.R, Velupillai, S, Talon, R, Collins, P.M, Krojer, T, Wang, D, Brandao-Neto, J, Douangamath, A, Burgess-Brown, N, Arrowsmith, C.H, Bountra, C, Huber, K, von Delft, F. | | 登録日 | 2019-02-22 | | 公開日 | 2019-05-08 | | 最終更新日 | 2024-03-06 | | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | | 主引用文献 | PanDDA analysis group deposition
To Be Published
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9CYC
 | | SARS-CoV-2 PLpro in complex with inhibitor WEHI-P2 | | 分子名称: | (E)-1-[(3R)-1-cyclopentylpiperidin-3-yl]-N-methoxy-1-(6-methoxynaphthalen-2-yl)methanimine, ACETIC ACID, GLYCEROL, ... | | 著者 | Calleja, D.J, Lechtenberg, B.C, Kuchel, N.W, Devine, S.M, Bader, S.M, Doerflinger, M, Mitchel, J.P, Lessene, G, Komander, D. | | 登録日 | 2024-08-01 | | 公開日 | 2025-04-09 | | 最終更新日 | 2025-04-16 | | 実験手法 | X-RAY DIFFRACTION (2.01 Å) | | 主引用文献 | A novel PLpro inhibitor improves outcomes in a pre-clinical model of long COVID.
Nat Commun, 16, 2025
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8YA2
 | | Structure of the SecA-SecY complex with the substrate FtsQ-LacY(+20C) | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, BERYLLIUM TRIFLUORIDE ION, Cell division protein FtsQ,Lactose permease, ... | | 著者 | Ou, X, Ma, C, Sun, D, Xu, J, Wu, X, Gao, N, Li, L. | | 登録日 | 2024-02-07 | | 公開日 | 2025-02-26 | | 最終更新日 | 2025-07-02 | | 実験手法 | ELECTRON MICROSCOPY (3.84 Å) | | 主引用文献 | SecY translocon chaperones protein folding during membrane protein insertion.
Cell, 188, 2025
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8YA0
 | | Structure of the SecA-SecY complex with the substrate FtsQ-LacY(+7C) | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, BERYLLIUM TRIFLUORIDE ION, Cell division protein FtsQ,Lactose permease, ... | | 著者 | Ou, X, Ma, C, Sun, D, Xu, J, Wu, X, Gao, N, Li, L. | | 登録日 | 2024-02-07 | | 公開日 | 2025-02-26 | | 最終更新日 | 2025-06-18 | | 実験手法 | ELECTRON MICROSCOPY (2.97 Å) | | 主引用文献 | SecY translocon chaperones protein folding during membrane protein insertion.
Cell, 188, 2025
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8YA3
 | | Structure of the SecA-SecY complex with the substrate FtsQ-LacY(+7C) treated with DTT | | 分子名称: | Cell division protein FtsQ,Lactose permease, Protein translocase subunit SecE, Protein translocase subunit SecY | | 著者 | Ou, X, Ma, C, Sun, D, Xu, J, Wu, X, Gao, N, Li, L. | | 登録日 | 2024-02-07 | | 公開日 | 2025-02-26 | | 最終更新日 | 2025-07-02 | | 実験手法 | ELECTRON MICROSCOPY (3.27 Å) | | 主引用文献 | SecY translocon chaperones protein folding during membrane protein insertion.
Cell, 188, 2025
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8YAS
 | | Structure of the SecA-SecY complex with the substrate HmBRI-7TM | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, BERYLLIUM TRIFLUORIDE ION, MAGNESIUM ION, ... | | 著者 | Ou, X, Ma, C, Sun, D, Xu, J, Wu, X, Gao, N, Li, L. | | 登録日 | 2024-02-10 | | 公開日 | 2025-02-26 | | 最終更新日 | 2025-07-02 | | 実験手法 | ELECTRON MICROSCOPY (3.97 Å) | | 主引用文献 | SecY translocon chaperones protein folding during membrane protein insertion.
Cell, 188, 2025
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8Y9Z
 | | Structure of the SecA-SecY complex with the substrate HmBRI-3TM | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, BERYLLIUM TRIFLUORIDE ION, Bacteriorhodopsin-I, ... | | 著者 | Ou, X, Ma, C, Sun, D, Xu, J, Wu, X, Gao, N, Li, L. | | 登録日 | 2024-02-07 | | 公開日 | 2025-02-26 | | 最終更新日 | 2025-06-25 | | 実験手法 | ELECTRON MICROSCOPY (3.41 Å) | | 主引用文献 | SecY translocon chaperones protein folding during membrane protein insertion.
Cell, 188, 2025
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8Y9Y
 | | Structure of the SecA-SecY complex with the substrate FtsQ-LacY(+1C) | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, BERYLLIUM TRIFLUORIDE ION, MAGNESIUM ION, ... | | 著者 | Ou, X, Ma, C, Sun, D, Xu, J, Wu, X, Gao, N, Li, L. | | 登録日 | 2024-02-07 | | 公開日 | 2025-02-26 | | 最終更新日 | 2025-06-25 | | 実験手法 | ELECTRON MICROSCOPY (3.29 Å) | | 主引用文献 | SecY translocon chaperones protein folding during membrane protein insertion.
Cell, 188, 2025
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5QOJ
 | | PanDDA analysis group deposition -- Crystal Structure of DCP2 (NUDT20) in complex with FMOCR000171b | | 分子名称: | 1,2-ETHANEDIOL, 2-(thiophen-2-yl)-1H-imidazole, ACETATE ION, ... | | 著者 | Nelson, E.R, Velupillai, S, Talon, R, Collins, P.M, Krojer, T, Wang, D, Brandao-Neto, J, Douangamath, A, Burgess-Brown, N, Arrowsmith, C.H, Bountra, C, Huber, K, von Delft, F. | | 登録日 | 2019-02-22 | | 公開日 | 2019-05-08 | | 最終更新日 | 2024-03-06 | | 実験手法 | X-RAY DIFFRACTION (2.05 Å) | | 主引用文献 | PanDDA analysis group deposition
To Be Published
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5QP3
 | | PanDDA analysis group deposition -- Crystal Structure of DCP2 (NUDT20) in complex with Z1494850193 | | 分子名称: | 1,2-ETHANEDIOL, ACETATE ION, DCP2 (NUDT20), ... | | 著者 | Nelson, E.R, Velupillai, S, Talon, R, Collins, P.M, Krojer, T, Wang, D, Brandao-Neto, J, Douangamath, A, Burgess-Brown, N, Arrowsmith, C.H, Bountra, C, Huber, K, von Delft, F. | | 登録日 | 2019-02-22 | | 公開日 | 2019-05-08 | | 最終更新日 | 2024-03-06 | | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | | 主引用文献 | PanDDA analysis group deposition
To Be Published
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6V05
 | | Cryo-EM structure of a substrate-engaged Bam complex | | 分子名称: | Outer membrane protein assembly factor BamA, Outer membrane protein assembly factor BamA,Outer membrane protein assembly factor BamA,Outer membrane protein assembly factor BamA,Outer membrane protein assembly factor BamA, Outer membrane protein assembly factor BamB, ... | | 著者 | Tomasek, D, Rawson, S, Lee, J, Wzorek, J.S, Harrison, S.C, Li, Z, Kahne, D. | | 登録日 | 2019-11-18 | | 公開日 | 2020-06-10 | | 最終更新日 | 2024-11-20 | | 実験手法 | ELECTRON MICROSCOPY (4.1 Å) | | 主引用文献 | Structure of a nascent membrane protein as it folds on the BAM complex.
Nature, 583, 2020
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5KNZ
 | | Human Islet Amyloid Polypeptide Segment 19-SGNNFGAILSS-29 with Early Onset S20G Mutation Determined by MicroED | | 分子名称: | hIAPP(residues 19-29)S20G | | 著者 | Krotee, P.A.L, Rodriguez, J.A, Sawaya, M.R, Cascio, D, Shi, D, Nannenga, B.L, Hattne, J, Reyes, F.E, Gonen, T, Eisenberg, D.S. | | 登録日 | 2016-06-28 | | 公開日 | 2016-12-21 | | 最終更新日 | 2024-03-06 | | 実験手法 | ELECTRON CRYSTALLOGRAPHY (1.9 Å) | | 主引用文献 | Atomic structures of fibrillar segments of hIAPP suggest tightly mated beta-sheets are important for cytotoxicity.
Elife, 6, 2017
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5BRV
 | | Catalytic Improvement of an Artificial Metalloenzyme by Computational Design | | 分子名称: | Carbonic anhydrase 2, ZINC ION, pentamethylcyclopentadienyl iridium [N-benzensulfonamide-(2-pyridylmethyl-4-benzensulfonamide)amin] chloride | | 著者 | Heinisch, T, Pellizzoni, M, Duerrenberger, M, Tinberg, C.E, Koehler, V, Klehr, J, Haeussinger, D, Baker, D, Ward, T.R. | | 登録日 | 2015-06-01 | | 公開日 | 2015-06-24 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | | 主引用文献 | Improving the Catalytic Performance of an Artificial Metalloenzyme by Computational Design.
J.Am.Chem.Soc., 137, 2015
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7M7W
 | | Antibodies to the SARS-CoV-2 receptor-binding domain that maximize breadth and resistance to viral escape | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Monoclonal antibody S2H97 Fab heavy chain, Monoclonal antibody S2H97 Fab light chain, ... | | 著者 | Snell, G, Czudnochowski, N, Croll, T.I, Nix, J.C, Corti, D, Cameroni, E, Pinto, D, Beltramello, M. | | 登録日 | 2021-03-29 | | 公開日 | 2021-05-05 | | 最終更新日 | 2024-10-16 | | 実験手法 | X-RAY DIFFRACTION (2.65 Å) | | 主引用文献 | SARS-CoV-2 RBD antibodies that maximize breadth and resistance to escape.
Nature, 597, 2021
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7OK0
 | | Cryo-EM structure of the Sulfolobus acidocaldarius RNA polymerase at 2.88 A | | 分子名称: | Conserved protein, DNA-directed RNA polymerase subunit A', DNA-directed RNA polymerase subunit A'', ... | | 著者 | Pilotto, S, Fouqueau, T, Lukoyanova, N, Sheppard, C, Lucas-Staat, S, Diaz-Santin, L.M, Matelska, D, Prangishvili, D, Cheung, A.C.M, Werner, F. | | 登録日 | 2021-05-17 | | 公開日 | 2021-08-25 | | 最終更新日 | 2024-10-23 | | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | | 主引用文献 | Structural basis of RNA polymerase inhibition by viral and host factors.
Nat Commun, 12, 2021
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7OQY
 | | Cryo-EM structure of the cellular negative regulator TFS4 bound to the archaeal RNA polymerase | | 分子名称: | Conserved protein, DNA-directed RNA polymerase subunit A', DNA-directed RNA polymerase subunit A'', ... | | 著者 | Pilotto, S, Fouqueau, T, Lukoyanova, N, Sheppard, C, Lucas-Staat, S, Diaz-Santin, L.M, Matelska, D, Prangishvili, D, Cheung, A.C.M, Werner, F. | | 登録日 | 2021-06-04 | | 公開日 | 2021-08-25 | | 最終更新日 | 2024-07-17 | | 実験手法 | ELECTRON MICROSCOPY (2.61 Å) | | 主引用文献 | Structural basis of RNA polymerase inhibition by viral and host factors.
Nat Commun, 12, 2021
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7OQ4
 | | Cryo-EM structure of the ATV RNAP Inhibitory Protein (RIP) bound to the DNA-binding channel of the host's RNA polymerase | | 分子名称: | Conserved protein, DNA-directed RNA polymerase subunit A', DNA-directed RNA polymerase subunit A'', ... | | 著者 | Pilotto, S, Fouqueau, T, Lukoyanova, N, Sheppard, C, Lucas-Staat, S, Diaz-Santin, L.M, Matelska, D, Prangishvili, D, Cheung, A.C.M, Werner, F. | | 登録日 | 2021-06-02 | | 公開日 | 2021-08-25 | | 最終更新日 | 2021-10-13 | | 実験手法 | ELECTRON MICROSCOPY (3.27 Å) | | 主引用文献 | Structural basis of RNA polymerase inhibition by viral and host factors.
Nat Commun, 12, 2021
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