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5VOV
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BU of 5vov by Molmil
Structure of AMPA receptor-TARP complex
分子名称: Glutamate receptor 2, Voltage-dependent calcium channel gamma-2 subunit
著者Zhao, Y, Chen, S, Wang, Y.S, Shekhar, M, Tajkhorshid, E, Gouaux, E.
登録日2017-05-03
公開日2017-07-12
最終更新日2024-10-30
実験手法ELECTRON MICROSCOPY (7.7 Å)
主引用文献Activation and Desensitization Mechanism of AMPA Receptor-TARP Complex by Cryo-EM.
Cell, 170, 2017
5IZA
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BU of 5iza by Molmil
Protein-protein interaction
分子名称: ACE-GLY-GLY-GLU-ALA-LEU-ALA-TRP-NH2, Adenomatous polyposis coli protein
著者Zhao, Y, Jiang, H, Yang, X, Jiang, F, Song, K, Zhang, J.
登録日2016-03-25
公開日2017-07-05
最終更新日2024-10-23
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献Peptidomimetic inhibitors of APC-Asef interaction block colorectal cancer migration.
Nat. Chem. Biol., 13, 2017
5IZ9
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BU of 5iz9 by Molmil
Protein-protein interaction
分子名称: ACE-GLY-GLY-GLU-ALA-LEU-ALA-ASP-NH2, Adenomatous polyposis coli protein
著者Zhao, Y, Jiang, H, Yang, X, Jiang, F, Song, K, Zhang, J.
登録日2016-03-25
公開日2017-07-05
最終更新日2024-10-30
実験手法X-RAY DIFFRACTION (2.93 Å)
主引用文献Peptidomimetic inhibitors of APC-Asef interaction block colorectal cancer migration.
Nat. Chem. Biol., 13, 2017
1PTY
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BU of 1pty by Molmil
CRYSTAL STRUCTURE OF PROTEIN TYROSINE PHOSPHATASE 1B COMPLEXED WITH TWO PHOSPHOTYROSINE MOLECULES
分子名称: MAGNESIUM ION, O-PHOSPHOTYROSINE, PROTEIN TYROSINE PHOSPHATASE 1B
著者Zhao, Y, Puius, Y.A, Sullivan, M, Lawrence, D, Almo, S.C, Zhang, Z.-Y.
登録日1997-01-16
公開日1998-01-21
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (1.85 Å)
主引用文献Identification of a second aryl phosphate-binding site in protein-tyrosine phosphatase 1B: a paradigm for inhibitor design.
Proc.Natl.Acad.Sci.USA, 94, 1997
6YSK
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BU of 6ysk by Molmil
1-phenylpyrroles and 1-enylpyrrolidines as inhibitors of Notum
分子名称: (3~{S})-1-[4-chloranyl-3-(trifluoromethyl)phenyl]pyrrolidine-3-carboxylic acid, 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, ...
著者Zhao, Y, Jones, E.Y, Fish, P.
登録日2020-04-22
公開日2020-09-16
最終更新日2024-11-06
実験手法X-RAY DIFFRACTION (1.21 Å)
主引用文献Screening of a Custom-Designed Acid Fragment Library Identifies 1-Phenylpyrroles and 1-Phenylpyrrolidines as Inhibitors of Notum Carboxylesterase Activity.
J.Med.Chem., 63, 2020
9BW8
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BU of 9bw8 by Molmil
Structure of P450Blt from Micromonospora sp. MW-13 in Complex with Fluorinated Biarylitide
分子名称: Cytochrome P450-SU1, Fluorinated Biarylitide, PROTOPORPHYRIN IX CONTAINING FE, ...
著者Hansen, M.H, Cryle, M.J, Zhao, Y.
登録日2024-05-21
公開日2024-11-20
最終更新日2024-11-27
実験手法X-RAY DIFFRACTION (1.86 Å)
主引用文献Loss of fluorine during crosslinking by the biarylitide P450 Blt proceeds due to restricted peptide orientation.
Chem.Commun.(Camb.), 60, 2024
7TRG
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BU of 7trg by Molmil
The beta-tubulin folding intermediate I
分子名称: ADENOSINE-5'-DIPHOSPHATE, ALUMINUM FLUORIDE, MAGNESIUM ION, ...
著者Zhao, Y, Frydman, J, Chiu, W.
登録日2022-01-28
公開日2022-12-28
最終更新日2024-06-12
実験手法ELECTRON MICROSCOPY (3 Å)
主引用文献Structural visualization of the tubulin folding pathway directed by human chaperonin TRiC/CCT.
Cell, 185, 2022
7TTN
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BU of 7ttn by Molmil
The beta-tubulin folding intermediate II
分子名称: ADENOSINE-5'-DIPHOSPHATE, ALUMINUM FLUORIDE, MAGNESIUM ION, ...
著者Zhao, Y, Frydman, J, Chiu, W.
登録日2022-02-01
公開日2022-12-28
最終更新日2024-06-12
実験手法ELECTRON MICROSCOPY (3.3 Å)
主引用文献Structural visualization of the tubulin folding pathway directed by human chaperonin TRiC/CCT.
Cell, 185, 2022
7TUB
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BU of 7tub by Molmil
The beta-tubulin folding intermediate IV
分子名称: ADENOSINE-5'-DIPHOSPHATE, ALUMINUM FLUORIDE, MAGNESIUM ION, ...
著者Zhao, Y, Frydman, J, Chiu, W.
登録日2022-02-02
公開日2022-12-28
最終更新日2024-06-12
実験手法ELECTRON MICROSCOPY (3.6 Å)
主引用文献Structural visualization of the tubulin folding pathway directed by human chaperonin TRiC/CCT.
Cell, 185, 2022
7TTT
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BU of 7ttt by Molmil
The beta-tubulin folding intermediate III
分子名称: ADENOSINE-5'-DIPHOSPHATE, ALUMINUM FLUORIDE, MAGNESIUM ION, ...
著者Zhao, Y, Frydman, J, Chiu, W.
登録日2022-02-01
公開日2022-12-28
最終更新日2024-06-12
実験手法ELECTRON MICROSCOPY (2.9 Å)
主引用文献Structural visualization of the tubulin folding pathway directed by human chaperonin TRiC/CCT.
Cell, 185, 2022
4Q65
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BU of 4q65 by Molmil
Structure of the E. coli Peptide Transporter YbgH
分子名称: Dipeptide permease D
著者Zhang, C, Zhao, Y, Mao, G, Liu, M, Wang, X.
登録日2014-04-21
公開日2014-08-13
最終更新日2024-05-29
実験手法X-RAY DIFFRACTION (3.4 Å)
主引用文献Crystal structure of the E. coli peptide transporter YbgH.
Structure, 22, 2014
6M03
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BU of 6m03 by Molmil
The crystal structure of COVID-19 main protease in apo form
分子名称: 3C-like proteinase
著者Zhang, B, Zhao, Y, Jin, Z, Liu, X, Yang, H, Rao, Z.
登録日2020-02-19
公開日2020-03-11
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Structural basis for replicase polyprotein cleavage and substrate specificity of main protease from SARS-CoV-2.
Proc.Natl.Acad.Sci.USA, 119, 2022
9J7N
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BU of 9j7n by Molmil
Cryo-EM structure of TauT
分子名称: BETA-ALANINE, CHLORIDE ION, CHOLESTEROL, ...
著者Zhao, Y, Xu, H.
登録日2024-08-19
公開日2025-04-02
最終更新日2025-07-02
実験手法ELECTRON MICROSCOPY (3.14 Å)
主引用文献Structural characterization reveals substrate recognition by the taurine transporter TauT.
Cell Discov, 11, 2025
9J7M
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BU of 9j7m by Molmil
Cryo-EM structure of TauT
分子名称: 2-AMINOETHANESULFONIC ACID, CHLORIDE ION, CHOLESTEROL, ...
著者Zhao, Y, Xu, H.
登録日2024-08-19
公開日2025-04-02
最終更新日2025-05-14
実験手法ELECTRON MICROSCOPY (2.82 Å)
主引用文献Structural characterization reveals substrate recognition by the taurine transporter TauT.
Cell Discov, 11, 2025
9J7O
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BU of 9j7o by Molmil
Cryo-EM structure of TauT
分子名称: CHLORIDE ION, CHOLESTEROL, HEXADECANE, ...
著者Zhao, Y, Xu, H.
登録日2024-08-19
公開日2025-04-02
最終更新日2025-05-14
実験手法ELECTRON MICROSCOPY (2.77 Å)
主引用文献Structural characterization reveals substrate recognition by the taurine transporter TauT.
Cell Discov, 11, 2025
6LPM
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BU of 6lpm by Molmil
Crystal structure of AP endonuclease from Deinococcus radioduran
分子名称: Exodeoxyribonuclease III
著者Zhao, Y, He, Y.
登録日2020-01-11
公開日2020-05-27
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献Structural and Functional Characterization of a Unique AP Endonuclease From Deinococcus radiodurans .
Front Microbiol, 11, 2020
8SLN
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BU of 8sln by Molmil
Crystal structure of Deinococcus geothermalis PprI complexed with ssDNA
分子名称: DNA (29-MER), MANGANESE (II) ION, Zn dependent hydrolase fused to HTH domain, ...
著者Zhao, Y, Lu, H.
登録日2023-04-23
公開日2024-03-13
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献The Deinococcus protease PprI senses DNA damage by directly interacting with single-stranded DNA.
Nat Commun, 15, 2024
8SLM
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BU of 8slm by Molmil
Crystal structure of Deinococcus geothermalis PprI
分子名称: MANGANESE (II) ION, SULFATE ION, Zn dependent hydrolase fused to HTH domain, ...
著者Zhao, Y, Lu, H.
登録日2023-04-23
公開日2024-03-13
実験手法X-RAY DIFFRACTION (2.81 Å)
主引用文献The Deinococcus protease PprI senses DNA damage by directly interacting with single-stranded DNA.
Nat Commun, 15, 2024
5F56
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BU of 5f56 by Molmil
Structure of RecJ complexed with DNA and SSB-ct
分子名称: ALA-ASP-LEU-PRO-PHE, DNA (5'-D(*CP*TP*GP*AP*TP*GP*GP*CP*A)-3'), MANGANESE (II) ION, ...
著者Zhao, Y, Hua, Y, Cheng, K.
登録日2015-12-04
公開日2016-06-15
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Structural basis for DNA 5 -end resection by RecJ
Elife, 5, 2016
8GXG
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BU of 8gxg by Molmil
The crystal structure of SARS-CoV-2 main protease in complex with 14a
分子名称: 3C-like proteinase nsp5, N-[(2S)-3-(4-fluorophenyl)-1-oxidanylidene-1-[[(2S,3S)-3-oxidanyl-4-oxidanylidene-1-[(3S)-2-oxidanylidenepiperidin-3-yl]-4-[(phenylmethyl)amino]butan-2-yl]amino]propan-2-yl]-1-benzofuran-2-carboxamide
著者Zhao, Y, Zhao, J, Shao, M, Yang, H, Rao, Z.
登録日2022-09-20
公開日2023-09-27
最終更新日2024-10-23
実験手法X-RAY DIFFRACTION (1.69 Å)
主引用文献Structure-based design of pan-coronavirus inhibitors targeting host cathepsin L and calpain-1.
Signal Transduct Target Ther, 9, 2024
8GXH
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BU of 8gxh by Molmil
The crystal structure of SARS-CoV-2 main protease in complex with 14b
分子名称: 3C-like proteinase nsp5, N-[(2S)-3-cyclohexyl-1-oxidanylidene-1-[[(2S,3R)-3-oxidanyl-4-oxidanylidene-1-[(3S)-2-oxidanylidenepiperidin-3-yl]-4-[(phenylmethyl)amino]butan-2-yl]amino]propan-2-yl]-1-benzofuran-2-carboxamide
著者Zhao, Y, Zhao, J, Shao, M, Yang, H, Rao, Z.
登録日2022-09-20
公開日2023-09-27
最終更新日2024-10-23
実験手法X-RAY DIFFRACTION (1.59 Å)
主引用文献Structure-based design of pan-coronavirus inhibitors targeting host cathepsin L and calpain-1.
Signal Transduct Target Ther, 9, 2024
7MPI
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BU of 7mpi by Molmil
Stm1 bound vacant 80S structure isolated from cbf5-D95A
分子名称: 18S rRNA, 25S rRNA, 40S ribosomal protein S0-A, ...
著者Rai, J, Zhao, Y, Li, H.
登録日2021-05-04
公開日2022-05-11
最終更新日2025-05-28
実験手法ELECTRON MICROSCOPY (3.05 Å)
主引用文献CryoEM structures of pseudouridine-free ribosome suggest impacts of chemical modifications on ribosome conformations.
Structure, 30, 2022
7MPJ
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BU of 7mpj by Molmil
Stm1 bound vacant 80S structure isolated from wild-type
分子名称: 18S rRNA, 25S rRNA, 40S ribosomal protein S0-A, ...
著者Rai, J, Zhao, Y, Li, H.
登録日2021-05-04
公開日2022-05-11
最終更新日2025-05-28
実験手法ELECTRON MICROSCOPY (2.7 Å)
主引用文献CryoEM structures of pseudouridine-free ribosome suggest impacts of chemical modifications on ribosome conformations.
Structure, 30, 2022
7N8B
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BU of 7n8b by Molmil
Cycloheximide bound vacant 80S structure isolated from cbf5-D95A
分子名称: 18S RIBOSOMAL RNA, 25S, 4-{(2R)-2-[(1S,3S,5S)-3,5-dimethyl-2-oxocyclohexyl]-2-hydroxyethyl}piperidine-2,6-dione, ...
著者Rai, J, Zhao, Y, Li, H.
登録日2021-06-14
公開日2022-05-11
最終更新日2025-05-21
実験手法ELECTRON MICROSCOPY (3.05 Å)
主引用文献CryoEM structures of pseudouridine-free ribosome suggest impacts of chemical modifications on ribosome conformations.
Structure, 30, 2022
8JCN
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BU of 8jcn by Molmil
The crystal structure of SARS-CoV-2 main protease in complex with Compound 58
分子名称: 1-[3-(diphenoxyphosphorylamino)phenyl]ethanone, 3C-like proteinase nsp5, DIMETHYL SULFOXIDE, ...
著者Zhao, Y, Zhu, Y, Rao, Z.
登録日2023-05-11
公開日2024-05-15
最終更新日2025-05-28
実験手法X-RAY DIFFRACTION (1.61 Å)
主引用文献De novo design of SARS-CoV-2 main protease inhibitors with characteristic binding modes.
Structure, 32, 2024

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