7KQP
 
 | | Crystal structure of SARS-CoV-2 NSP3 macrodomain in complex with ADP-ribose (P43 crystal form) | | 分子名称: | Non-structural protein 3, [(2R,3S,4R,5R)-5-(6-AMINOPURIN-9-YL)-3,4-DIHYDROXY-OXOLAN-2-YL]METHYL [HYDROXY-[[(2R,3S,4R,5S)-3,4,5-TRIHYDROXYOXOLAN-2-YL]METHOXY]PHOSPHORYL] HYDROGEN PHOSPHATE | | 著者 | Correy, G.J, Young, I.D, Thompson, M.C, Fraser, J.S. | | 登録日 | 2020-11-17 | | 公開日 | 2020-12-09 | | 最終更新日 | 2024-03-06 | | 実験手法 | X-RAY DIFFRACTION (0.88 Å) | | 主引用文献 | Fragment binding to the Nsp3 macrodomain of SARS-CoV-2 identified through crystallographic screening and computational docking.
Sci Adv, 7, 2021
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7KQW
 | | Crystal structure of SARS-CoV-2 NSP3 macrodomain (C2 crystal form, methylated) | | 分子名称: | Non-structural protein 3 | | 著者 | Correy, G.J, Young, I.D, Thompson, M.C, Fraser, J.S. | | 登録日 | 2020-11-17 | | 公開日 | 2020-12-09 | | 最終更新日 | 2023-11-15 | | 実験手法 | X-RAY DIFFRACTION (0.93 Å) | | 主引用文献 | Fragment binding to the Nsp3 macrodomain of SARS-CoV-2 identified through crystallographic screening and computational docking.
Sci Adv, 7, 2021
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7KKJ
 | | Structure of anti-SARS-CoV-2 Spike nanobody mNb6 | | 分子名称: | CHLORIDE ION, SULFATE ION, Synthetic nanobody mNb6 | | 著者 | Schoof, M.S, Faust, B.F, Saunders, R.A, Sangwan, S, Rezelj, V, Hoppe, N, Boone, M, Billesboelle, C.B, Puchades, C, Azumaya, C.M, Kratochvil, H.T, Zimanyi, M, Desphande, I, Liang, J, Dickinson, S, Nguyen, H.C, Chio, C.M, Merz, G.E, Thompson, M.C, Diwanji, D, Schaefer, K, Anand, A.A, Dobzinski, N, Zha, B.S, Simoneau, C.R, Leon, K, White, K.M, Chio, U.S, Gupta, M, Jin, M, Li, F, Liu, Y, Zhang, K, Bulkley, D, Sun, M, Smith, A.M, Rizo, A.N, Moss, F, Brilot, A.F, Pourmal, S, Trenker, R, Pospiech, T, Gupta, S, Barsi-Rhyne, B, Belyy, V, Barile-Hill, A.W, Nock, S, Liu, Y, Krogan, N.J, Ralston, C.Y, Swaney, D.L, Garcia-Sastre, A, Ott, M, Vignuzzi, M, Walter, P, Manglik, A, QCRG Structural Biology Consortium | | 登録日 | 2020-10-27 | | 公開日 | 2020-11-25 | | 最終更新日 | 2024-10-30 | | 実験手法 | X-RAY DIFFRACTION (2.05 Å) | | 主引用文献 | An ultrapotent synthetic nanobody neutralizes SARS-CoV-2 by stabilizing inactive Spike.
Science, 370, 2020
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6OB5
 | | Computationally-designed, modular sense/response system (S3-2D) | | 分子名称: | Ankyrin Repeat Domain (AR), S3-2D variant, FARNESYL DIPHOSPHATE, ... | | 著者 | Thompson, M.C, Glasgow, A.A, Huang, Y.M, Fraser, J.S, Kortemme, T. | | 登録日 | 2019-03-19 | | 公開日 | 2019-12-04 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (2.208 Å) | | 主引用文献 | Computational design of a modular protein sense-response system.
Science, 366, 2019
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8TSY
 | | Pseudomonas fluorescens G150T-2 isocyanide hydratase at 274 K | | 分子名称: | CHLORIDE ION, Isonitrile hydratase InhA | | 著者 | Wilson, M.A, Smith, N, Dasgupta, M, Dolamore, C. | | 登録日 | 2023-08-12 | | 公開日 | 2023-09-20 | | 最終更新日 | 2025-05-07 | | 実験手法 | X-RAY DIFFRACTION (1.2 Å) | | 主引用文献 | Changes in an enzyme ensemble during catalysis observed by high-resolution XFEL crystallography.
Sci Adv, 10, 2024
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8TT0
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8TT2
 | | Pseudomonas fluorescens isocyanide hydratase pH=5.4 | | 分子名称: | 1,2-ETHANEDIOL, Isonitrile hydratase InhA | | 著者 | Wilson, M.A, Smith, N, Dasgupta, M, Dolamore, C. | | 登録日 | 2023-08-12 | | 公開日 | 2023-09-20 | | 最終更新日 | 2025-05-07 | | 実験手法 | X-RAY DIFFRACTION (1.33 Å) | | 主引用文献 | Changes in an enzyme ensemble during catalysis observed by high-resolution XFEL crystallography.
Sci Adv, 10, 2024
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8TSZ
 | | Pseudomonas fluorescens G150T-3 isocyanide hydratase at 274 K | | 分子名称: | CHLORIDE ION, Isonitrile hydratase InhA | | 著者 | Wilson, M.A, Smith, N, Dasgupta, M, Dolamore, C. | | 登録日 | 2023-08-12 | | 公開日 | 2023-09-20 | | 最終更新日 | 2025-05-07 | | 実験手法 | X-RAY DIFFRACTION (1.1 Å) | | 主引用文献 | Changes in an enzyme ensemble during catalysis observed by high-resolution XFEL crystallography.
Sci Adv, 10, 2024
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8TT4
 | | Pseudomonas fluorescens isocyanide hydratase pH=6.0 | | 分子名称: | 1,2-ETHANEDIOL, Isonitrile hydratase InhA | | 著者 | Wilson, M.A, Smith, N, Dasgupta, M, Dolamore, C. | | 登録日 | 2023-08-12 | | 公開日 | 2023-09-20 | | 最終更新日 | 2025-05-07 | | 実験手法 | X-RAY DIFFRACTION (1.2 Å) | | 主引用文献 | Changes in an enzyme ensemble during catalysis observed by high-resolution XFEL crystallography.
Sci Adv, 10, 2024
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8TSU
 | | Pseudomonas fluorescens G150T-1 isocyanide hydratase at 274 K | | 分子名称: | CHLORIDE ION, Isonitrile hydratase InhA | | 著者 | Wilson, M.A, Smith, N, Dasgupta, M, Dolamore, C. | | 登録日 | 2023-08-11 | | 公開日 | 2023-09-20 | | 最終更新日 | 2025-05-07 | | 実験手法 | X-RAY DIFFRACTION (1.15 Å) | | 主引用文献 | Changes in an enzyme ensemble during catalysis observed by high-resolution XFEL crystallography.
Sci Adv, 10, 2024
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8TSX
 | | Pseudomonas fluorescens G150T isocyanide hydratase at 100 K | | 分子名称: | CHLORIDE ION, Isonitrile hydratase InhA | | 著者 | Wilson, M.A, Smith, N, Dasgupta, M, Dolamore, C. | | 登録日 | 2023-08-12 | | 公開日 | 2023-09-20 | | 最終更新日 | 2025-05-07 | | 実験手法 | X-RAY DIFFRACTION (1 Å) | | 主引用文献 | Changes in an enzyme ensemble during catalysis observed by high-resolution XFEL crystallography.
Sci Adv, 10, 2024
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8TT5
 | | Pseudomonas fluorescens isocyanide hydratase pH=8.3 | | 分子名称: | 1,2-ETHANEDIOL, Isonitrile hydratase InhA | | 著者 | Wilson, M.A, Smith, N, Dasgupta, M, Dolamore, C. | | 登録日 | 2023-08-12 | | 公開日 | 2023-09-20 | | 最終更新日 | 2025-05-07 | | 実験手法 | X-RAY DIFFRACTION (1.02 Å) | | 主引用文献 | Changes in an enzyme ensemble during catalysis observed by high-resolution XFEL crystallography.
Sci Adv, 10, 2024
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8TT1
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8GC8
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8GC7
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8FRC
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8FRA
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8FRB
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8FRD
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8GCA
 | | Mouse acidic mammalian chitinase, catalytic domain in complex with N,N',N''-triacetylchitotriose at pH 4.74 | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Acidic mammalian chitinase, ... | | 著者 | Diaz, R.E, Fraser, J.S. | | 登録日 | 2023-03-01 | | 公開日 | 2023-03-15 | | 最終更新日 | 2024-11-06 | | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | | 主引用文献 | Structural characterization of ligand binding and pH-specific enzymatic activity of mouse Acidic Mammalian Chitinase.
Biorxiv, 2024
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8FR9
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8FRG
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5HPN
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8USK
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8USE
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