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Crystal structure of Trypanosoma brucei nucleoside phosphorylase shows uridine phosphorylase activity
Descriptor:	1-O-phosphono-alpha-D-ribofuranose, CALCIUM ION, Nucleoside phosphorylase, ...
Authors:	Larson, E.T, Merritt, E.A, Structural Genomics of Pathogenic Protozoa Consortium (SGPP)
Deposit date:	2007-12-03
Release date:	2007-12-18
Last modified:	2024-02-21
Method:	X-RAY DIFFRACTION (1.44 Å)
Cite:	The Crystal Structure and Activity of a Putative Trypanosomal Nucleoside Phosphorylase Reveal It to be a Homodimeric Uridine Phosphorylase J.Mol.Biol., 396, 2010

6MZA

Solution NMR structure of a putative thioredoxin (trxA) in the reduced state from Rickettsia prowazekii, the etiological agent responsible for typhus. Seattle Structural Genomics Center for Infectious Disease target RiprA.00029.a
Descriptor:	Thioredoxin
Authors:	Buchko, G.W, Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:	2018-11-04
Release date:	2018-12-12
Last modified:	2024-05-01
Method:	SOLUTION NMR
Cite:	Solution NMR structure of reduced Rickettsia prowazekii thioredoxin. To Be Published

4JBV

Calcium-Dependent Protein Kinase 1 from Toxoplasma gondii (TgCDPK1) in complex with inhibitor UW1268
Descriptor:	1-[(1-methylpiperidin-4-yl)methyl]-3-[6-(2-methylpropoxy)naphthalen-2-yl]pyrazolo[3,4-d]pyrimidin-4-amine, Calmodulin-domain protein kinase 1
Authors:	Merritt, E.A, Larson, E.T.
Deposit date:	2013-02-20
Release date:	2014-03-19
Last modified:	2024-02-28
Method:	X-RAY DIFFRACTION (1.95 Å)
Cite:	Development of potent and selective Plasmodium falciparum calcium-dependent protein kinase 4 (PfCDPK4) inhibitors that block the transmission of malaria to mosquitoes. Eur.J.Med.Chem., 74, 2014

3HGB

Crystal structure of glycine cleavage system protein H from Mycobacterium tuberculosis
Descriptor:	Glycine cleavage system H protein
Authors:	Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:	2009-05-13
Release date:	2009-05-26
Last modified:	2023-09-06
Method:	X-RAY DIFFRACTION (1.75 Å)
Cite:	X-ray structure determination of the glycine cleavage system protein H of Mycobacterium tuberculosis using an inverse Compton synchrotron X-ray source. J.Struct.Funct.Genom., 11, 2010

5IFU

Crystal Structure of Prolyl-tRNA synthetase (ProRS, Proline--tRNA ligase) from Plasmodium falciparum in complex with Glyburide
Descriptor:	1,2-ETHANEDIOL, 5-chloro-N-(2-{4-[(cyclohexylcarbamoyl)sulfamoyl]phenyl}ethyl)-2-methoxybenzamide, CHLORIDE ION, ...
Authors:	Dranow, D.M, Hewitt, S.N, Abendroth, J, Structural Genomics Consortium (SGC)
Deposit date:	2016-02-26
Release date:	2016-11-16
Last modified:	2023-09-27
Method:	X-RAY DIFFRACTION (2.45 Å)
Cite:	Biochemical and Structural Characterization of Selective Allosteric Inhibitors of the Plasmodium falciparum Drug Target, Prolyl-tRNA-synthetase. ACS Infect Dis, 3, 2017

4M84

Calcium-Dependent Protein Kinase 1 from Toxoplasma gondii (TgCDPK1) in complex with inhibitor UW1455
Descriptor:	5-amino-1-tert-butyl-3-(quinolin-2-yl)-1H-pyrazole-4-carboxamide, Calmodulin-domain protein kinase 1
Authors:	Merritt, E.A.
Deposit date:	2013-08-12
Release date:	2013-10-02
Last modified:	2023-09-20
Method:	X-RAY DIFFRACTION (1.998 Å)
Cite:	Potent and selective inhibitors of CDPK1 from T. gondii and C. parvum based on a 5-aminopyrazole-4-carboxamide scaffold. ACS Med Chem Lett, 5, 2014

5IRD

Solution structure of Rv1466 from Mycobacterium tuberculosis, a protein associated with [Fe-S] complex assembly and repair - Seattle Structural Genomics Center for Infectious Disease target MytuD.17486.a
Descriptor:	Uncharacterized protein
Authors:	Buchko, G.W, Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:	2016-03-13
Release date:	2016-05-25
Last modified:	2024-05-15
Method:	SOLUTION NMR
Cite:	Solution structure of Rv1466, a Mycobacterium tuberculosis protein associated with [Fe-S] cluster assembly and repair. To Be Published

5K0T

Crystal structure of methionyl-tRNA synthetase MetRS from Brucella melitensis in complex with inhibitor Chem 1415
Descriptor:	1,2-ETHANEDIOL, 1-{3-[(3-chloro-5-methoxybenzyl)amino]propyl}-3-phenylurea, Methionine--tRNA ligase
Authors:	Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:	2016-05-17
Release date:	2016-05-25
Last modified:	2023-09-27
Method:	X-RAY DIFFRACTION (2.6 Å)
Cite:	Brucella melitensis Methionyl-tRNA-Synthetase (MetRS), a Potential Drug Target for Brucellosis. Plos One, 11, 2016

5K0S

Crystal structure of methionyl-tRNA synthetase MetRS from Brucella melitensis in complex with inhibitor Chem 1312
Descriptor:	2-({3-[(3,5-dichlorobenzyl)amino]propyl}amino)quinolin-4(1H)-one, Methionine--tRNA ligase
Authors:	Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:	2016-05-17
Release date:	2016-05-25
Last modified:	2023-09-27
Method:	X-RAY DIFFRACTION (2.45 Å)
Cite:	Brucella melitensis Methionyl-tRNA-Synthetase (MetRS), a Potential Drug Target for Brucellosis. Plos One, 11, 2016

6UHW

Solution structure of an organic hydroperoxide resistance protein from Burkholderia pseudomallei. Seattle Structural Genomics Center for Infectious Disease target BupsA.00074.a.
Descriptor:	Organic hydroperoxide resistance protein
Authors:	Buchko, G.W, Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:	2019-09-29
Release date:	2019-10-16
Last modified:	2024-05-15
Method:	SOLUTION NMR
Cite:	Backbone and side chain (1)H, (13)C, and (15)N NMR assignments for the organic hydroperoxide resistance protein (Ohr) from Burkholderia pseudomallei. Biomol.Nmr Assign., 3, 2009

6VYE

6-phosphogluconolactonase from Trypanosoma cruzi
Descriptor:	6-phosphogluconolactonase, GLYCEROL, PHOSPHATE ION
Authors:	Merritt, E.A, Structural Genomics of Pathogenic Protozoa Consortium (SGPP)
Deposit date:	2020-02-26
Release date:	2020-03-18
Last modified:	2023-10-11
Method:	X-RAY DIFFRACTION (1.95 Å)
Cite:	6-phosphogluconolactonase from Trypanosoma cruzi To be published

7N8I

SARS-CoV-2 S (B.1.429 / epsilon variant) + S2M11 + S2L20 (Local Refinement of the NTD/S2L20)
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, S2L20 Fab Heavy Chain Variable Region, S2L20 Fab Light Chain Variable Region, ...
Authors:	McCallum, M, Seattle Structural Genomics Center for Infectious Disease (SSGCID), Veesler, D.
Deposit date:	2021-06-14
Release date:	2021-07-14
Last modified:	2021-08-18
Method:	ELECTRON MICROSCOPY (3 Å)
Cite:	SARS-CoV-2 immune evasion by the B.1.427/B.1.429 variant of concern. Science, 373, 2021

7N8H

SARS-CoV-2 S (B.1.429 / epsilon variant) + S2M11 + S2L20 Global Refinement
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:	McCallum, M, Veesler, D, Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:	2021-06-14
Release date:	2021-07-14
Last modified:	2021-08-18
Method:	ELECTRON MICROSCOPY (2.3 Å)
Cite:	SARS-CoV-2 immune evasion by the B.1.427/B.1.429 variant of concern. Science, 373, 2021

1GYQ

CRYSTAL STRUCTURE OF GLYCOSOMAL GLYCERALDEHYDE FROM LEISHMANIA MEXICANA IN COMPLEX WITH N6-BENZYL-NAD
Descriptor:	N6-BENZYL-NICOTINAMIDE-ADENINE-DINUCLEOTIDE, PROTEIN (GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE)
Authors:	Suresh, S, Hol, W.
Deposit date:	1999-03-05
Release date:	1999-03-16
Last modified:	2023-08-09
Method:	X-RAY DIFFRACTION (3.4 Å)
Cite:	Structure-based design of submicromolar, biologically active inhibitors of trypanosomatid glyceraldehyde-3-phosphate dehydrogenase. Proc.Natl.Acad.Sci.USA, 96, 1999

7TXX

Solution structure for Bartonella henselae BamE, a component of the beta-barrel assembly machinery complex. Seattle Structural Genomics Center for Infectious Disease target BaheA.17605.a
Descriptor:	BA5
Authors:	Buchko, G.W, Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:	2022-02-10
Release date:	2022-03-02
Last modified:	2024-05-15
Method:	SOLUTION NMR
Cite:	Structural characterization of Bartonella henselae BamE, a component of the beta-barrel assembly machinery complex To Be Published

7UBF

Solution NMR structure of 8-residue Rosetta-designed cyclic peptide D8.21 in 50% d6-DMSO and 50% water with cis/trans switching (CC conformation, 50%)
Descriptor:	Cyclic peptide D8.21 DVA-MLE-DPR-LEU-DVA-MLE-DPR-LEU
Authors:	Ramelot, T.A, Tejero, R, Montelione, G.T.
Deposit date:	2022-03-14
Release date:	2022-09-14
Last modified:	2022-09-28
Method:	SOLUTION NMR
Cite:	Accurate de novo design of membrane-traversing macrocycles. Cell, 185, 2022

7UBD

Solution NMR structure of 8-residue Rosetta-designed cyclic peptide D8.31 in d6-DMSO with cis/trans switching (A-CC conformation)
Descriptor:	Cyclic peptide D8.31 DAL-DPR-MLU-DVA-DAL-DPR-MLU-DVA
Authors:	Ramelot, T.A, Tejero, R, Montelione, G.T.
Deposit date:	2022-03-14
Release date:	2022-09-14
Last modified:	2022-09-28
Method:	SOLUTION NMR
Cite:	Accurate de novo design of membrane-traversing macrocycles. Cell, 185, 2022

7UBI

Solution NMR structure of 8-residue Rosetta-designed cyclic peptide D8.21 in CDCl3 with cis/trans switching (TT conformation, 47%)
Descriptor:	Cyclic peptide D8.21 DVA-MLE-DPR-LEU-DVA-MLE-DPR-LEU
Authors:	Ramelot, T.A, Tejero, R, Montelione, G.T.
Deposit date:	2022-03-14
Release date:	2022-09-14
Last modified:	2022-09-28
Method:	SOLUTION NMR
Cite:	Accurate de novo design of membrane-traversing macrocycles. Cell, 185, 2022

7UCP

computationally designed macrocycle
Descriptor:	computationally designed cyclic peptide D8.3.p2
Authors:	Bhardwaj, G, Baker, D, Rettie, S, Glynn, C, Sawaya, M.
Deposit date:	2022-03-17
Release date:	2022-09-14
Last modified:	2022-09-28
Method:	X-RAY DIFFRACTION (0.85 Å)
Cite:	Accurate de novo design of membrane-traversing macrocycles. Cell, 185, 2022

7UZL

Solution NMR structure of 9-residue Rosetta-designed cyclic peptide D9.16 in CDCl3 with cis/trans switching (B-TC conformation)
Descriptor:	Cyclic peptide D9.16 DPR-MAA-ALA-DVA-MLE-LEU-LEU-PRO-DLE
Authors:	Ramelot, T.A, Tejero, R, Montelione, G.T.
Deposit date:	2022-05-09
Release date:	2022-09-14
Last modified:	2022-09-28
Method:	SOLUTION NMR
Cite:	Accurate de novo design of membrane-traversing macrocycles. Cell, 185, 2022

7UBC

Solution NMR structure of 9-residue Rosetta-designed cyclic peptide D9.16 in d6-DMSO with cis/trans switching
Descriptor:	Cyclic peptide D9.16 DPR-MAA-ALA-DVA-MLE-LEU-LEU-PRO-DLE
Authors:	Ramelot, T.A, Tejero, R, Monteltione, G.T.
Deposit date:	2022-03-14
Release date:	2022-09-14
Last modified:	2022-09-28
Method:	SOLUTION NMR
Cite:	Accurate de novo design of membrane-traversing macrocycles. Cell, 185, 2022

7UBE

Solution NMR structure of 8-residue Rosetta-designed cyclic peptide D8.21 in d6-DMSO with cis/trans switching
Descriptor:	Cyclic peptide D8.21 DVA-MLE-DPR-LEU-DVA-MLE-DPR-LEU
Authors:	Ramelot, T.A, Tejero, R, Montelione, G.T.
Deposit date:	2022-03-14
Release date:	2022-09-14
Last modified:	2022-09-28
Method:	SOLUTION NMR
Cite:	Accurate de novo design of membrane-traversing macrocycles. Cell, 185, 2022

7UBG

Solution NMR structure of 9-residue Rosetta-designed cyclic peptide D9.16 in CDCl3 with cis/trans switching (A-TT conformation)
Descriptor:	Cyclic peptide D9.16 DPR-MAA-ALA-DVA-MLE-LEU-LEU-PRO-DLE
Authors:	Ramelot, T.A, Tejero, R, Montelione, G.T.
Deposit date:	2022-03-14
Release date:	2022-09-14
Last modified:	2022-09-28
Method:	SOLUTION NMR
Cite:	Accurate de novo design of membrane-traversing macrocycles. Cell, 185, 2022

7UBH

Solution NMR structure of 8-residue Rosetta-designed cyclic peptide D8.31 in CDCl3 with cis/trans switching
Descriptor:	Cyclic peptide D8.31 DAL-DPR-MLU-DVA-DAL-DPR-MLU-DVA
Authors:	Ramelot, T.A, Tejero, R, Montelione, G.T.
Deposit date:	2022-03-14
Release date:	2022-09-14
Last modified:	2022-09-28
Method:	SOLUTION NMR
Cite:	Accurate de novo design of membrane-traversing macrocycles. Cell, 185, 2022

7UWQ

Klebsiella pneumoniae adenosine monophosphate nucleosidase
Descriptor:	AMP nucleosidase
Authors:	Richardson, B.C, French, J.B.
Deposit date:	2022-05-03
Release date:	2022-09-28
Last modified:	2024-06-12
Method:	ELECTRON MICROSCOPY (3.05 Å)
Cite:	Structure of Klebsiella pneumoniae adenosine monophosphate nucleosidase. Plos One, 17, 2022

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Total results:	451
Displayed results:	25
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