4DXL
| |
4ED4
| |
4EMD
| |
4EGE
| |
2O8M
| Crystal structure of the S139A mutant of Hepatitis C Virus NS3/4A protease | Descriptor: | Protease, SODIUM ION, ZINC ION | Authors: | Fischmann, T.O, Prongay, A.J, Madison, V.M, Yao, N. | Deposit date: | 2006-12-12 | Release date: | 2007-10-09 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Discovery of the HCV NS3/4A protease inhibitor (1R,5S)-N-[3-amino-1-(cyclobutylmethyl)-2,3-dioxopropyl]-3- [2(S)-[[[(1,1-dimethylethyl)amino]carbonyl]amino]-3,3-dimethyl-1-oxobutyl]- 6,6-dimethyl-3-azabicyclo[3.1.0]hexan-2(S)-carboxamide (Sch 503034) II. Key steps in structure-based optimization J.Med.Chem., 50, 2007
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5EJ2
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3MOY
| |
3NDN
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3NF4
| |
3NWO
| |
3OC7
| |
3OI9
| |
3P2Y
| |
3P5M
| |
3P4I
| |
3HGB
| |
3MPZ
| |
3MYB
| |
3O38
| |
3OC6
| |
3NDO
| |
3NG3
| |
3NJD
| |
3O0M
| |
3OME
| |