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Quadruple mutant plasmodium falciparum dihydrofolate reductase complexed with B10042
Descriptor:	5-(3-chlorophenyl)-6-(3-phenoxypropyl)pyrimidine-2,4-diamine, Bifunctional dihydrofolate reductase-thymidylate synthase, GLYCEROL, ...
Authors:	Vanichtanankul, J, Vitsupakorn, D.
Deposit date:	2019-08-14
Release date:	2019-12-04
Last modified:	2023-11-22
Method:	X-RAY DIFFRACTION (1.973 Å)
Cite:	6-Hydrophobic aromatic substituent pyrimethamine analogues as potential antimalarials for pyrimethamine-resistant Plasmodium falciparum. Bioorg.Med.Chem., 27, 2019

Quadruple mutant (N51I+C59R+S108N+I164L) plasmodium falciparum dihydrofolate reductase-thymidylate synthase (PfDHFR-TS) complexed with B12128 and NADPH
Descriptor:	2'-DEOXYURIDINE 5'-MONOPHOSPHATE, 4-[3-[[2,6-bis(azanyl)-5-(3-chlorophenyl)pyrimidin-4-yl]methoxy]phenoxy]butanoic acid, Bifunctional dihydrofolate reductase-thymidylate synthase, ...
Authors:	Vanichtanankul, J, Vitsupakorn, D.
Deposit date:	2019-08-13
Release date:	2019-12-04
Last modified:	2023-11-22
Method:	X-RAY DIFFRACTION (2.149 Å)
Cite:	6-Hydrophobic aromatic substituent pyrimethamine analogues as potential antimalarials for pyrimethamine-resistant Plasmodium falciparum. Bioorg.Med.Chem., 27, 2019

Quadruple mutant (N51I+C59R+S108N+I164L) plasmodium falciparum dihydrofolate reductase-thymidylate synthase (PfDHFR-TS) complexed with B12155 inhibitor
Descriptor:	2'-DEOXYURIDINE 5'-MONOPHOSPHATE, 4-[3-[3-[2,6-bis(azanyl)-5-(3-chlorophenyl)pyrimidin-4-yl]propoxy]phenoxy]butanoic acid, Bifunctional dihydrofolate reductase-thymidylate synthase, ...
Authors:	Vanichtanankul, J, Vitsupakorn, D.
Deposit date:	2019-08-15
Release date:	2019-12-04
Last modified:	2023-11-22
Method:	X-RAY DIFFRACTION (2.1 Å)
Cite:	6-Hydrophobic aromatic substituent pyrimethamine analogues as potential antimalarials for pyrimethamine-resistant Plasmodium falciparum. Bioorg.Med.Chem., 27, 2019