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The SARS-CoV-2 receptor binding domain bound with the Fab fragment of a human neutralizing antibody Ab326
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Ab326 heavy chain, Ab326 light chain, ...
Authors:	Kamada, K, Shirouzu, M.
Deposit date:	2022-03-15
Release date:	2022-12-07
Last modified:	2022-12-21
Method:	ELECTRON MICROSCOPY (4.2 Å)
Cite:	Potent SARS-CoV-2 neutralizing antibodies with therapeutic effects in two animal models. Iscience, 25, 2022

The SARS-CoV-2 receptor binding domain bound with the Fab fragment of a human neutralizing antibody Ab445
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Ab445 heavy chain, Ab445 light chain, ...
Authors:	Kamada, K, Shirouzu, M.
Deposit date:	2022-03-15
Release date:	2022-12-07
Last modified:	2022-12-21
Method:	ELECTRON MICROSCOPY (4.1 Å)
Cite:	Potent SARS-CoV-2 neutralizing antibodies with therapeutic effects in two animal models. Iscience, 25, 2022

Crystal Structure of the Kinase domain of Human VEGFR2 with imidazo[1,2-b]pyridazine derivative
Descriptor:	1,2-ETHANEDIOL, N-[3-({2-[(cyclopropylcarbonyl)amino]imidazo[1,2-b]pyridazin-6-yl}oxy)phenyl]-1,3-dimethyl-1H-pyrazole-5-carboxamide, Vascular endothelial growth factor receptor 2
Authors:	Oki, H, Okada, K.
Deposit date:	2012-01-19
Release date:	2013-03-06
Last modified:	2024-03-20
Method:	X-RAY DIFFRACTION (1.52 Å)
Cite:	Discovery of N-[5-({2-[(cyclopropylcarbonyl)amino]imidazo[1,2-b]pyridazin-6-yl}oxy)-2-methylphenyl]-1,3-dimethyl-1H-pyrazole-5-carboxamide (TAK-593), a highly potent VEGFR2 kinase inhibitor Bioorg.Med.Chem., 21, 2013