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Structure of the catalytic domain of PARP1 in complex with talazoparib
Descriptor:	(8S,9R)-5-fluoro-8-(4-fluorophenyl)-9-(1-methyl-1H-1,2,4-triazol-5-yl)-2,7,8,9-tetrahydro-3H-pyrido[4,3,2-de]phthalazin-3-one, Poly [ADP-ribose] polymerase 1
Authors:	Gajiwala, K.S, Ryan, K.
Deposit date:	2020-10-27
Release date:	2021-01-06
Last modified:	2023-10-18
Method:	X-RAY DIFFRACTION (2.06 Å)
Cite:	Dissecting the molecular determinants of clinical PARP1 inhibitor selectivity for tankyrase1. J.Biol.Chem., 296, 2021

Reversible lysine-targeted probes reveal residence time-based kinase selectivity in vivo
Descriptor:	6-[(5-cyclopropyl-1~{H}-pyrazol-3-yl)amino]-2-[4-[(3-methyl-4-oxidanyl-phenyl)methyl]piperazin-1-yl]-~{N}-prop-2-ynyl-pyrimidine-4-carboxamide, Aurora kinase A, CHLORIDE ION
Authors:	Craven, G.B, Wan, X.B, Taunton, J.
Deposit date:	2021-07-31
Release date:	2022-06-08
Last modified:	2023-11-29
Method:	X-RAY DIFFRACTION (2.32 Å)
Cite:	Reversible lysine-targeted probes reveal residence time-based kinase selectivity. Nat.Chem.Biol., 18, 2022