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4DMZ
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BU of 4dmz by Molmil
PelD 156-455 from Pseudomonas aeruginosa PA14, apo form
Descriptor: 1,2-ETHANEDIOL, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, MAGNESIUM ION, ...
Authors:Whitney, J.C, Colvin, K.M, Marmont, L.S, Robinson, H, Parsek, M.R, Howell, P.L.
Deposit date:2012-02-08
Release date:2012-05-23
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.102 Å)
Cite:Structure of the Cytoplasmic Region of PelD, a Degenerate Diguanylate Cyclase Receptor That Regulates Exopolysaccharide Production in Pseudomonas aeruginosa.
J.Biol.Chem., 287, 2012
4F9J
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BU of 4f9j by Molmil
Structure of Escherichia coli PgaB 42-655 in complex with iron
Descriptor: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, ACETIC ACID, CALCIUM ION, ...
Authors:Little, D.J, Poloczek, J, Whitney, J.C, Robinson, H, Nitz, M, Howell, P.L.
Deposit date:2012-05-18
Release date:2012-07-25
Last modified:2013-06-26
Method:X-RAY DIFFRACTION (2.103 Å)
Cite:The Structure and Metal Dependent Activity of Escherichia coli PgaB Provides Insight into the Partial De-N-acetylation of Poly-b-1,6-N-acetyl-D-glucosamine
J.Biol.Chem., 287, 2012
4WCJ
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BU of 4wcj by Molmil
Structure of IcaB from Ammonifex degensii
Descriptor: CHLORIDE ION, Polysaccharide deacetylase, ZINC ION
Authors:Little, D.J, Bamford, N.C, Pokrovskaya, V, Robinson, H, Nitz, M, Howell, P.L.
Deposit date:2014-09-04
Release date:2014-11-12
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Structural Basis for the De-N-acetylation of Poly-beta-1,6-N-acetyl-d-glucosamine in Gram-positive Bacteria.
J.Biol.Chem., 289, 2014
2QSU
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BU of 2qsu by Molmil
Structure of Arabidopsis thaliana 5'-Methylthioadenosine nucleosidase in apo form
Descriptor: 5'-methylthioadenosine nucleosidase
Authors:Siu, K.K.W, Howell, P.L.
Deposit date:2007-07-31
Release date:2008-04-01
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (2 Å)
Cite:Molecular determinants of substrate specificity in plant 5'-methylthioadenosine nucleosidases.
J.Mol.Biol., 378, 2008
2C44
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BU of 2c44 by Molmil
Crystal Structure of E. coli Tryptophanase
Descriptor: POTASSIUM ION, SULFATE ION, TRYPTOPHANASE
Authors:Ku, S.-Y, Yip, P, Howell, P.L.
Deposit date:2005-10-15
Release date:2006-06-28
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structure of Escherichia Coli Tryptophanase
Acta Crystallogr.,Sect.D, 62, 2006
6OLJ
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BU of 6olj by Molmil
CryoEM structure of PilB from Geobacter metallireducens: C2ccocco conformation
Descriptor: Type IV pilus biogenesis ATPase PilB
Authors:McCallum, M, Howell, P.L.
Deposit date:2019-04-16
Release date:2019-11-20
Last modified:2023-08-16
Method:ELECTRON MICROSCOPY (7.8 Å)
Cite:Multiple conformations facilitate PilT function in the type IV pilus.
Nat Commun, 10, 2019
7SA8
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BU of 7sa8 by Molmil
Crystal Structure of the periplasmic lyase AlgL K66A Mutant
Descriptor: Alginate lyase
Authors:Gheorghita, A.A, Pfoh, R, Wong, S.S.Y, Howell, P.L.
Deposit date:2021-09-22
Release date:2022-08-03
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:The Pseudomonas aeruginosa homeostasis enzyme AlgL clears the periplasmic space of accumulated alginate during polymer biosynthesis.
J.Biol.Chem., 298, 2022
6OK2
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BU of 6ok2 by Molmil
PilT4 from Geobacter metallireducens bound to ADP: C3ocococ conformation
Descriptor: ADENOSINE-5'-DIPHOSPHATE, Twitching motility pilus retraction ATPase
Authors:McCallum, M, Howell, P.L.
Deposit date:2019-04-12
Release date:2019-11-20
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (3.287 Å)
Cite:Multiple conformations facilitate PilT function in the type IV pilus.
Nat Commun, 10, 2019
6OLL
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BU of 6oll by Molmil
CryoEM structure of PilT4 from Geobacter metallireducens without adding nucleotide: C2oocooc conformation
Descriptor: Twitching motility pilus retraction ATPase
Authors:McCallum, M, Howell, P.L.
Deposit date:2019-04-16
Release date:2019-11-20
Last modified:2024-03-20
Method:ELECTRON MICROSCOPY (4.1 Å)
Cite:Multiple conformations facilitate PilT function in the type IV pilus.
Nat Commun, 10, 2019
7T8N
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BU of 7t8n by Molmil
Crystal structure of the PNAG binding module PgaA-TPR 220-359
Descriptor: CHLORIDE ION, MAGNESIUM ION, Poly-beta-1,6-N-acetyl-D-glucosamine export protein
Authors:Pfoh, R, Little, D.J, Howell, P.L.
Deposit date:2021-12-16
Release date:2022-08-03
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.85 Å)
Cite:The TPR domain of PgaA is a multifunctional scaffold that binds PNAG and modulates PgaB-dependent polymer processing.
Plos Pathog., 18, 2022
6OJZ
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BU of 6ojz by Molmil
PilT4 from Geobacter metallireducens bound to ADP with partial occupancy: C3ocococ conformation
Descriptor: ADENOSINE-5'-DIPHOSPHATE, Twitching motility pilus retraction ATPase
Authors:McCallum, M, Howell, P.L.
Deposit date:2019-04-12
Release date:2019-11-20
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (3.027 Å)
Cite:Multiple conformations facilitate PilT function in the type IV pilus.
Nat Commun, 10, 2019
4DN0
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BU of 4dn0 by Molmil
PelD 156-455 from Pseudomonas aeruginosa PA14 in complex with c-di-GMP
Descriptor: 9,9'-[(2R,3R,3aS,5S,7aR,9R,10R,10aS,12S,14aR)-3,5,10,12-tetrahydroxy-5,12-dioxidooctahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8]tetraoxadiphosphacyclododecine-2,9-diyl]bis(2-amino-1,9-dihydro-6H-purin-6-one), Putative uncharacterized protein pelD, SODIUM ION, ...
Authors:Whitney, J.C, Colvin, K.M, Marmont, L.S, Robinson, H, Parsek, M.R, Howell, P.L.
Deposit date:2012-02-08
Release date:2012-05-23
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structure of the Cytoplasmic Region of PelD, a Degenerate Diguanylate Cyclase Receptor That Regulates Exopolysaccharide Production in Pseudomonas aeruginosa.
J.Biol.Chem., 287, 2012
6WJB
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BU of 6wjb by Molmil
UDP-GlcNAc C4-epimerase from Pseudomonas protegens in complex with NAD and UDP-GlcNAc
Descriptor: NAD-dependent epimerase/dehydratase family protein, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, URIDINE-DIPHOSPHATE-N-ACETYLGLUCOSAMINE
Authors:Marmont, L.S, Pfoh, R, Robinson, H, Howell, P.L.
Deposit date:2020-04-13
Release date:2020-07-08
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:PelX is a UDP-N-acetylglucosamine C4-epimerase involved in Pel polysaccharide-dependent biofilm formation.
J.Biol.Chem., 295, 2020
3O4V
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BU of 3o4v by Molmil
Crystal structure of E. coli MTA/SAH nucleosidase in complex with (4-Chlorophenyl)thio-DADMe-ImmA
Descriptor: (3R,4S)-1-[(4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]-4-{[(4-chlorophenyl)sulfanyl]methyl}pyrrolidin-3-ol, GLYCEROL, ISOPROPYL ALCOHOL, ...
Authors:Siu, K.K.W, Howell, P.L.
Deposit date:2010-07-27
Release date:2010-08-11
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Crystal structure of E. coli MTA/SAH nucleosidase in complex with (4-Chlorophenyl)thio-DADMe-ImmA
To be Published
3PG0
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BU of 3pg0 by Molmil
Crystal structure of designed 3-fold symmetric protein, ThreeFoil
Descriptor: 2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, GLYCEROL, SODIUM ION, ...
Authors:Lobsanov, Y.D, Broom, A, Howell, P.L, Rose, D.R, Meiering, E.M.
Deposit date:2010-10-29
Release date:2011-12-21
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (1.62 Å)
Cite:Modular evolution and the origins of symmetry: reconstruction of a three-fold symmetric globular protein.
Structure, 20, 2012
3CQT
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BU of 3cqt by Molmil
N53I V55L MUTANT of FYN SH3 DOMAIN
Descriptor: Proto-oncogene tyrosine-protein kinase Fyn
Authors:Neculai, A.M, Zarrine-Afsar, A, Howell, P.L, Davidson, A, Chan, H.S.
Deposit date:2008-04-03
Release date:2008-07-01
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Theoretical and experimental demonstration of the importance of specific nonnative interactions in protein folding.
Proc.Natl.Acad.Sci.Usa, 105, 2008
3DF9
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BU of 3df9 by Molmil
Crystal structure of E. coli MTA/SAH nucleosidase in complex with BnT-DADMeImmA
Descriptor: (3R,4S)-1-[(4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]-4-[(benzylsulfanyl)methyl]pyrrolidin-3-ol, MTA/SAH nucleosidase
Authors:Siu, K.K.W, Howell, P.L.
Deposit date:2008-06-11
Release date:2009-03-17
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Structure of Staphylococcus aureus 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase
Acta Crystallogr.,Sect.F, 64, 2008
3FZ2
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BU of 3fz2 by Molmil
Crystal structure of the tail terminator protein from phage lambda (gpU-D74A)
Descriptor: Minor tail protein U, SULFATE ION
Authors:Pell, L.G, Liu, A, Edmonds, E, Donaldson, L.W, Howell, P.L, Davidson, A.R.
Deposit date:2009-01-23
Release date:2009-05-26
Last modified:2024-10-09
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:The X-ray crystal structure of the phage lambda tail terminator protein reveals the biologically relevant hexameric ring structure and demonstrates a conserved mechanism of tail termination among diverse long-tailed phages.
J.Mol.Biol., 389, 2009
1KP3
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BU of 1kp3 by Molmil
Crystal Structure of E. coli Argininosuccinate Synthetase in Complex with ATP and Citrulline
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, CITRULLINE, GUANIDINE, ...
Authors:Lemke, C.T, Howell, P.L.
Deposit date:2001-12-27
Release date:2002-04-17
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2 Å)
Cite:Substrate Induced Conformational Changes in Argininosuccinate Synthetase
J.Biol.Chem., 277, 2002
1KP2
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BU of 1kp2 by Molmil
Crystal Structure of E. coli Argininosuccinate Synthetase in Complex with ATP
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, GUANIDINE, PHOSPHATE ION, ...
Authors:Lemke, C.T, Howell, P.L.
Deposit date:2001-12-27
Release date:2002-04-17
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (2 Å)
Cite:Substrate Induced Conformational Changes in Argininosuccinate Synthetase
J.Biol.Chem., 277, 2002
5TSY
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BU of 5tsy by Molmil
Structure of the glycoside hydrolase domain of PelA variant E218A from Pseudomonas aeruginosa
Descriptor: PelA
Authors:Baker, P, Pfoh, R, Howell, P.L.
Deposit date:2016-10-31
Release date:2017-11-08
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Microbial glycoside hydrolases display cross-kingdom activity against bacterial and fungal biofilms
To Be Published
5TCB
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BU of 5tcb by Molmil
Structure of the glycoside hydrolase domain of PelA from Pseudomonas aeruginosa
Descriptor: PelA
Authors:Alnabelseya, N, Baker, P, Robinson, H, Howell, P.L.
Deposit date:2016-09-14
Release date:2017-09-20
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (1.535 Å)
Cite:Microbial glycoside hydrolases display cross-kingdom activity against bacterial and fungal biofilms
To Be Published
6AU1
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BU of 6au1 by Molmil
Structure of the PgaB (BpsB) glycoside hydrolase domain from Bordetella bronchiseptica
Descriptor: 1,2-ETHANEDIOL, CHLORIDE ION, Putative hemin storage protein, ...
Authors:Little, D.J, Bamford, N.C, Howell, P.L.
Deposit date:2017-08-30
Release date:2018-04-18
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.76 Å)
Cite:PgaB orthologues contain a glycoside hydrolase domain that cleaves deacetylated poly-beta (1,6)-N-acetylglucosamine and can disrupt bacterial biofilms.
PLoS Pathog., 14, 2018
6BT4
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BU of 6bt4 by Molmil
Crystal structure of the SLH domain of Sap from Bacillus anthracis in complex with a pyruvylated SCWP unit
Descriptor: 2-(acetylamino)-4-O-{2-(acetylamino)-4,6-O-[(1S)-1-carboxyethylidene]-2-deoxy-beta-D-mannopyranosyl}-2-deoxy-beta-D-glucopyranose, S-layer protein sap, SULFATE ION
Authors:Sychantha, D, Chapman, R.N, Bamford, N.C, Boons, G.J, Howell, P.L, Clarke, A.J.
Deposit date:2017-12-05
Release date:2018-03-21
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.306 Å)
Cite:Molecular Basis for the Attachment of S-Layer Proteins to the Cell Wall of Bacillus anthracis.
Biochemistry, 57, 2018
6CZT
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BU of 6czt by Molmil
CS-rosetta determined structures of the N-terminal domain of AlgF from P. aeruginosa
Descriptor: Alginate biosynthesis protein AlgF
Authors:Tammam, S, Howell, P.L.
Deposit date:2018-04-09
Release date:2019-04-17
Last modified:2024-05-01
Method:SOLUTION NMR
Cite:Pseudomonas aeruginosa AlgF is an adaptor protein required for acetylation of the alginate exopolysaccharide
To Be Published

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