7FPU
 
 | | DHFR:NADP+:FOL complex at 290 K (crystal 4) | | Descriptor: | Dihydrofolate reductase, FOLIC ACID, MANGANESE (II) ION, ... | | Authors: | Greisman, J.B, Dalton, K.M, Brookner, D.E, Hekstra, D.R. | | Deposit date: | 2022-09-10 | | Release date: | 2023-09-20 | | Method: | X-RAY DIFFRACTION (1.05 Å) | | Cite: | DHFR:NADP+:FOL complex at 290 K
To Be Published
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7FPO
 | | DHFR:NADP+:FOL complex at 280 K (crystal 4) | | Descriptor: | Dihydrofolate reductase, FOLIC ACID, MANGANESE (II) ION, ... | | Authors: | Greisman, J.B, Dalton, K.M, Brookner, D.E, Hekstra, D.R. | | Deposit date: | 2022-09-09 | | Release date: | 2023-09-20 | | Method: | X-RAY DIFFRACTION (1.06 Å) | | Cite: | DHFR:NADP+:FOL complex at 280 K
To Be Published
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7FPY
 | | DHFR:NADP+:FOL complex at 300 K (crystal 2) | | Descriptor: | Dihydrofolate reductase, FOLIC ACID, MANGANESE (II) ION, ... | | Authors: | Greisman, J.B, Dalton, K.M, Brookner, D.E, Hekstra, D.R. | | Deposit date: | 2022-09-10 | | Release date: | 2023-09-20 | | Method: | X-RAY DIFFRACTION (1.12 Å) | | Cite: | DHFR:NADP+:FOL complex at 300 K
To Be Published
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7FPX
 | | DHFR:NADP+:FOL complex at 300 K (crystal 1) | | Descriptor: | Dihydrofolate reductase, FOLIC ACID, MANGANESE (II) ION, ... | | Authors: | Greisman, J.B, Dalton, K.M, Brookner, D.E, Hekstra, D.R. | | Deposit date: | 2022-09-10 | | Release date: | 2023-09-20 | | Method: | X-RAY DIFFRACTION (1.06 Å) | | Cite: | DHFR:NADP+:FOL complex at 300 K
To Be Published
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7FPZ
 | | DHFR:NADP+:FOL complex at 300 K (crystal 3) | | Descriptor: | Dihydrofolate reductase, FOLIC ACID, MANGANESE (II) ION, ... | | Authors: | Greisman, J.B, Dalton, K.M, Brookner, D.E, Hekstra, D.R. | | Deposit date: | 2022-09-10 | | Release date: | 2023-09-20 | | Method: | X-RAY DIFFRACTION (1.32 Å) | | Cite: | DHFR:NADP+:FOL complex at 300 K
To Be Published
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7FPW
 | | DHFR:NADP+:FOL complex at 290 K (multi-crystal) | | Descriptor: | Dihydrofolate reductase, FOLIC ACID, MANGANESE (II) ION, ... | | Authors: | Greisman, J.B, Dalton, K.M, Brookner, D.E, Hekstra, D.R. | | Deposit date: | 2022-09-10 | | Release date: | 2023-09-20 | | Method: | X-RAY DIFFRACTION (1.04 Å) | | Cite: | DHFR:NADP+:FOL complex at 290 K
To Be Published
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7FQ0
 | | DHFR:NADP+:FOL complex at 300 K (crystal 4) | | Descriptor: | Dihydrofolate reductase, FOLIC ACID, MANGANESE (II) ION, ... | | Authors: | Greisman, J.B, Dalton, K.M, Brookner, D.E, Hekstra, D.R. | | Deposit date: | 2022-09-10 | | Release date: | 2023-09-20 | | Method: | X-RAY DIFFRACTION (1.15 Å) | | Cite: | DHFR:NADP+:FOL complex at 300 K
To Be Published
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7FQ1
 | | DHFR:NADP+:FOL complex at 300 K (crystal 5) | | Descriptor: | Dihydrofolate reductase, FOLIC ACID, MANGANESE (II) ION, ... | | Authors: | Greisman, J.B, Dalton, K.M, Brookner, D.E, Hekstra, D.R. | | Deposit date: | 2022-09-10 | | Release date: | 2023-09-20 | | Method: | X-RAY DIFFRACTION (1.18 Å) | | Cite: | DHFR:NADP+:FOL complex at 300 K
To Be Published
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7FQ3
 | | DHFR:NADP+:FOL complex at 310 K (crystal 1) | | Descriptor: | Dihydrofolate reductase, FOLIC ACID, MANGANESE (II) ION, ... | | Authors: | Greisman, J.B, Dalton, K.M, Brookner, D.E, Hekstra, D.R. | | Deposit date: | 2022-09-12 | | Release date: | 2023-09-20 | | Method: | X-RAY DIFFRACTION (1.3 Å) | | Cite: | DHFR:NADP+:FOL complex at 310 K
To Be Published
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7FQ2
 | | DHFR:NADP+:FOL complex at 300 K (multi-crystal) | | Descriptor: | Dihydrofolate reductase, FOLIC ACID, MANGANESE (II) ION, ... | | Authors: | Greisman, J.B, Dalton, K.M, Brookner, D.E, Hekstra, D.R. | | Deposit date: | 2022-09-10 | | Release date: | 2023-09-20 | | Method: | X-RAY DIFFRACTION (1.07 Å) | | Cite: | DHFR:NADP+:FOL complex at 300 K
To Be Published
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7FQ9
 | | DHFR:NADP+:FOL complex (crystal 1, pass 3, 295 K) | | Descriptor: | Dihydrofolate reductase, FOLIC ACID, MANGANESE (II) ION, ... | | Authors: | Greisman, J.B, Dalton, K.M, Brookner, D.E, Hekstra, D.R. | | Deposit date: | 2022-09-12 | | Release date: | 2023-09-20 | | Method: | X-RAY DIFFRACTION (1.11 Å) | | Cite: | Single-crystal, multi-temperature experiment of DHFR:NADP+:FOL complex
To Be Published
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7FQ5
 | | DHFR:NADP+:FOL complex at 310 K (crystal 3) | | Descriptor: | Dihydrofolate reductase, FOLIC ACID, MANGANESE (II) ION, ... | | Authors: | Greisman, J.B, Dalton, K.M, Brookner, D.E, Hekstra, D.R. | | Deposit date: | 2022-09-12 | | Release date: | 2023-09-20 | | Method: | X-RAY DIFFRACTION (1.35 Å) | | Cite: | DHFR:NADP+:FOL complex at 310 K
To Be Published
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7FQ8
 | | DHFR:NADP+:FOL complex (crystal 1, pass 2, 310 K) | | Descriptor: | Dihydrofolate reductase, FOLIC ACID, MANGANESE (II) ION, ... | | Authors: | Greisman, J.B, Dalton, K.M, Brookner, D.E, Hekstra, D.R. | | Deposit date: | 2022-09-12 | | Release date: | 2023-09-20 | | Method: | X-RAY DIFFRACTION (1.21 Å) | | Cite: | Single-crystal, multi-temperature experiment of DHFR:NADP+:FOL complex
To Be Published
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7FQA
 | | DHFR:NADP+:FOL complex (crystal 1, pass 4, 280 K) | | Descriptor: | Dihydrofolate reductase, FOLIC ACID, MANGANESE (II) ION, ... | | Authors: | Greisman, J.B, Dalton, K.M, Brookner, D.E, Hekstra, D.R. | | Deposit date: | 2022-09-12 | | Release date: | 2023-09-20 | | Method: | X-RAY DIFFRACTION (1.08 Å) | | Cite: | Single-crystal, multi-temperature experiment of DHFR:NADP+:FOL complex
To Be Published
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7FQ4
 | | DHFR:NADP+:FOL complex at 310 K (crystal 2) | | Descriptor: | Dihydrofolate reductase, FOLIC ACID, MANGANESE (II) ION, ... | | Authors: | Greisman, J.B, Dalton, K.M, Brookner, D.E, Hekstra, D.R. | | Deposit date: | 2022-09-12 | | Release date: | 2023-09-20 | | Method: | X-RAY DIFFRACTION (1.33 Å) | | Cite: | DHFR:NADP+:FOL complex at 310 K
To Be Published
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7FQB
 | | DHFR:NADP+:FOL complex (crystal 1, pass 5, 295 K) | | Descriptor: | Dihydrofolate reductase, FOLIC ACID, MANGANESE (II) ION, ... | | Authors: | Greisman, J.B, Dalton, K.M, Brookner, D.E, Hekstra, D.R. | | Deposit date: | 2022-09-12 | | Release date: | 2023-09-20 | | Method: | X-RAY DIFFRACTION (1.14 Å) | | Cite: | Single-crystal, multi-temperature experiment of DHFR:NADP+:FOL complex
To Be Published
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7FQ7
 | | DHFR:NADP+:FOL complex (crystal 1, pass 1, 295 K) | | Descriptor: | Dihydrofolate reductase, FOLIC ACID, MANGANESE (II) ION, ... | | Authors: | Greisman, J.B, Dalton, K.M, Brookner, D.E, Hekstra, D.R. | | Deposit date: | 2022-09-12 | | Release date: | 2023-09-20 | | Method: | X-RAY DIFFRACTION (1.1 Å) | | Cite: | Single-crystal, multi-temperature experiment of DHFR:NADP+:FOL complex
To Be Published
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7FQC
 | | DHFR:NADP+:FOL complex (crystal 2, pass 1, 295 K) | | Descriptor: | Dihydrofolate reductase, FOLIC ACID, MANGANESE (II) ION, ... | | Authors: | Greisman, J.B, Dalton, K.M, Brookner, D.E, Hekstra, D.R. | | Deposit date: | 2022-09-12 | | Release date: | 2023-09-20 | | Method: | X-RAY DIFFRACTION (1.18 Å) | | Cite: | Single-crystal, multi-temperature experiment of DHFR:NADP+:FOL complex
To Be Published
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7FQF
 | | DHFR:NADP+:FOL complex (crystal 2, pass 4, 310 K) | | Descriptor: | Dihydrofolate reductase, FOLIC ACID, MANGANESE (II) ION, ... | | Authors: | Greisman, J.B, Dalton, K.M, Brookner, D.E, Hekstra, D.R. | | Deposit date: | 2022-09-12 | | Release date: | 2023-09-20 | | Method: | X-RAY DIFFRACTION (1.23 Å) | | Cite: | Single-crystal, multi-temperature experiment of DHFR:NADP+:FOL complex
To Be Published
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7FQ6
 | | DHFR:NADP+:FOL complex at 310 K (multi-crystal) | | Descriptor: | Dihydrofolate reductase, FOLIC ACID, MANGANESE (II) ION, ... | | Authors: | Greisman, J.B, Dalton, K.M, Brookner, D.E, Hekstra, D.R. | | Deposit date: | 2022-09-12 | | Release date: | 2023-09-20 | | Method: | X-RAY DIFFRACTION (1.29 Å) | | Cite: | DHFR:NADP+:FOL complex at 310 K
To Be Published
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7FQD
 | | DHFR:NADP+:FOL complex (crystal 2, pass 2, 280 K) | | Descriptor: | Dihydrofolate reductase, FOLIC ACID, MANGANESE (II) ION, ... | | Authors: | Greisman, J.B, Dalton, K.M, Brookner, D.E, Hekstra, D.R. | | Deposit date: | 2022-09-12 | | Release date: | 2023-09-20 | | Method: | X-RAY DIFFRACTION (1.17 Å) | | Cite: | Single-crystal, multi-temperature experiment of DHFR:NADP+:FOL complex
To Be Published
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7FQG
 | | DHFR:NADP+:FOL complex (crystal 2, pass 5, 295 K) | | Descriptor: | Dihydrofolate reductase, FOLIC ACID, MANGANESE (II) ION, ... | | Authors: | Greisman, J.B, Dalton, K.M, Brookner, D.E, Hekstra, D.R. | | Deposit date: | 2022-09-12 | | Release date: | 2023-09-20 | | Method: | X-RAY DIFFRACTION (1.19 Å) | | Cite: | Single-crystal, multi-temperature experiment of DHFR:NADP+:FOL complex
To Be Published
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7FQE
 | | DHFR:NADP+:FOL complex (crystal 2, pass 3, 295 K) | | Descriptor: | Dihydrofolate reductase, FOLIC ACID, MANGANESE (II) ION, ... | | Authors: | Greisman, J.B, Dalton, K.M, Brookner, D.E, Hekstra, D.R. | | Deposit date: | 2022-09-12 | | Release date: | 2023-09-20 | | Method: | X-RAY DIFFRACTION (1.18 Å) | | Cite: | Single-crystal, multi-temperature experiment of DHFR:NADP+:FOL complex
To Be Published
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7L84
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8T7Q
 | | Identification of GDC-1971 (RLY-1971), a SHP2 inhibitor designed for the treatment of solid tumors | | Descriptor: | 1-{3-[(2-chlorophenyl)sulfanyl]-1H-pyrazolo[3,4-b]pyrazin-6-yl}-4-methylpiperidin-4-amine, Tyrosine-protein phosphatase non-receptor type 11 | | Authors: | Tang, Y, Nguyen, V, Wilbur, J.D. | | Deposit date: | 2023-06-21 | | Release date: | 2023-10-11 | | Last modified: | 2023-10-25 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Identification of GDC-1971 (RLY-1971), a SHP2 Inhibitor Designed for the Treatment of Solid Tumors.
J.Med.Chem., 66, 2023
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