6ECT
| StiE O-MT residues 961-1257 | Descriptor: | S-ADENOSYLMETHIONINE, StiE protein | Authors: | Skiba, M.A, Bivins, M.M, Smith, J.L. | Deposit date: | 2018-08-08 | Release date: | 2018-12-12 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (1.42 Å) | Cite: | Structural Basis of Polyketide Synthase O-Methylation. ACS Chem. Biol., 13, 2018
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6ECU
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6ECW
| StiD O-MT residues 956-1266 | Descriptor: | S-ADENOSYL-L-HOMOCYSTEINE, StiD protein | Authors: | Skiba, M.A, Bivins, M.M, Smith, J.L. | Deposit date: | 2018-08-08 | Release date: | 2018-12-12 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Structural Basis of Polyketide Synthase O-Methylation. ACS Chem. Biol., 13, 2018
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3QIT
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4MYZ
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4MYY
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4MZ0
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3KG6
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3KG8
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3KG7
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3KG9
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4HNP
| Crystal structure of yeast 20S proteasome in complex with vinylketone carmaphycin analogue VNK1 | Descriptor: | N-hexanoyl-L-valyl-N~1~-[(3S,4S)-3-hydroxy-2,6-dimethylhept-1-en-4-yl]-N~5~,N~5~-dimethyl-L-glutamamide, N-hexanoyl-L-valyl-N~1~-[(3S,4S)-3-hydroxy-2,6-dimethylheptan-4-yl]-N~5~,N~5~-dimethyl-L-glutamamide, Proteasome component C1, ... | Authors: | Trivella, D.B.B, Stein, M, Groll, M. | Deposit date: | 2012-10-20 | Release date: | 2014-01-29 | Last modified: | 2014-07-02 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Enzyme inhibition by hydroamination: design and mechanism of a hybrid carmaphycin-syringolin enone proteasome inhibitor. Chem.Biol., 21, 2014
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5DOZ
| Crystal structure of JamJ enoyl reductase (NADPH bound) | Descriptor: | ACETATE ION, JamJ, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | Authors: | Khare, D, Smith, J.L. | Deposit date: | 2015-09-11 | Release date: | 2015-11-18 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.26 Å) | Cite: | Structural Basis for Cyclopropanation by a Unique Enoyl-Acyl Carrier Protein Reductase. Structure, 23, 2015
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5DOV
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5DP2
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5DP1
| Crystal structure of CurK enoyl reductase | Descriptor: | CurK, GLYCEROL, PHOSPHATE ION | Authors: | Khare, D, Smith, J.L. | Deposit date: | 2015-09-12 | Release date: | 2015-11-18 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (1.85 Å) | Cite: | Structural Basis for Cyclopropanation by a Unique Enoyl-Acyl Carrier Protein Reductase. Structure, 23, 2015
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4HRC
| Crystal structure of yeast 20S proteasome in complex with epoxyketone carmaphycin analogue 3 | Descriptor: | N-hexanoyl-L-valyl-N~1~-[(2R,3S,4S)-1,3-dihydroxy-2,6-dimethylheptan-4-yl]-N~5~,N~5~-dimethyl-L-glutamamide, Proteasome component C1, Proteasome component C11, ... | Authors: | Trivella, D.B.B, Stein, M, Groll, M. | Deposit date: | 2012-10-27 | Release date: | 2014-01-29 | Last modified: | 2014-07-02 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Enzyme inhibition by hydroamination: design and mechanism of a hybrid carmaphycin-syringolin enone proteasome inhibitor. Chem.Biol., 21, 2014
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4HRD
| Crystal structure of yeast 20S proteasome in complex with the natural product carmaphycin A | Descriptor: | N-[(2S)-1-({(2S)-1-{[(2R,3S,4S)-1,3-dihydroxy-2,6-dimethylheptan-4-yl]amino}-4-[(R)-methylsulfinyl]-1-oxobutan-2-yl}amino)-3-methyl-1-oxobutan-2-yl]hexanamide, Proteasome component C1, Proteasome component C11, ... | Authors: | Trivella, D.B.B, Stein, M, Groll, M. | Deposit date: | 2012-10-27 | Release date: | 2014-01-29 | Last modified: | 2014-07-02 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Enzyme inhibition by hydroamination: design and mechanism of a hybrid carmaphycin-syringolin enone proteasome inhibitor. Chem.Biol., 21, 2014
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7R7G
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7R7F
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7R7E
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2REF
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7S19
| Crystal structure of cruzain with gallinamide analog from 2-indolyl series | Descriptor: | Cruzipain, N,N-dimethyl-L-valyl-L-leucyl-N-[(3S)-6-{(2S)-2-[(1H-indol-3-yl)methyl]-3-methoxy-5-oxo-2,5-dihydro-1H-pyrrol-1-yl}-6-oxo-1-phenylhexan-3-yl]-L-leucinamide | Authors: | Sharma, V, Podust, L.M. | Deposit date: | 2021-09-01 | Release date: | 2022-03-02 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.08 Å) | Cite: | Intramolecular Interactions Enhance the Potency of Gallinamide A Analogues against Trypanosoma cruzi . J.Med.Chem., 65, 2022
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7S18
| Crystal structure of cruzain with gallinamide analog from 2-biaryl series | Descriptor: | Cruzipain, N,N-dimethyl-L-valyl-L-leucyl-N-[(3S)-6-{(2S)-2-[([1,1'-biphenyl]-4-yl)methyl]-3-methoxy-5-oxo-2,5-dihydro-1H-pyrrol-1-yl}-6-oxo-1-phenylhexan-3-yl]-L-leucinamide | Authors: | Sharma, V, Podust, L.M. | Deposit date: | 2021-09-01 | Release date: | 2022-03-02 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.14 Å) | Cite: | Intramolecular Interactions Enhance the Potency of Gallinamide A Analogues against Trypanosoma cruzi . J.Med.Chem., 65, 2022
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2Q2X
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