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Crystal structure of human KRAS G12C covalently bound to an acryloylazetidine acetamide inhibitor
Descriptor:	2-[5-chloro-2-cyclopropyl-3-(5-methoxy-3,4-dihydroisoquinoline-2(1H)-carbonyl)-7-methyl-1H-indol-1-yl]-N-(1-propanoylazetidin-3-yl)acetamide, CALCIUM ION, GTPase KRas, ...
Authors:	Mohr, C.
Deposit date:	2019-06-08
Release date:	2019-08-28
Last modified:	2019-10-02
Method:	X-RAY DIFFRACTION (1.65 Å)
Cite:	Discovery ofN-(1-Acryloylazetidin-3-yl)-2-(1H-indol-1-yl)acetamides as Covalent Inhibitors of KRASG12C. Acs Med.Chem.Lett., 10, 2019

Crystal structure of PI3K-gamma in complex with a quinoline inhibitor
Descriptor:	N-{2-chloro-5-[4-(morpholin-4-yl)quinolin-6-yl]pyridin-3-yl}-4-fluorobenzenesulfonamide, Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform, SULFATE ION
Authors:	Whittington, D.A, Tang, J, Yakowec, P.
Deposit date:	2011-05-16
Release date:	2011-06-08
Last modified:	2023-09-13
Method:	X-RAY DIFFRACTION (2.55 Å)
Cite:	Phospshoinositide 3-Kinase (PI3K)/Mammalian Target of Rapamycin (mTOR) Dual Inhibitors: Discovery and Structure-Activity Relationships of a Series of Quinoline and Quinoxaline Derivatives. J.Med.Chem., 54, 2011