 | | PRD_001074 | | Name: | Thiocillin GE2270 analogue NVP-LDI028 | | Formula: | C55 H64 N13 O10 S6 | | Definition date: | 2012-12-12 | | Last modified: | 2012-12-12 |
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 | | PRD_001073 | | Name: | Thiocillin GE2270 analogue NVP-LDK733 | | Formula: | C55 H64 N13 O11 S6 | | Definition date: | 2012-12-12 | | Last modified: | 2012-12-12 |
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 | | PRD_001072 | | Name: | Thiocillin GE2270 analogue NVP-LFF571 | | Formula: | C60 H72 N13 O13 S6 | | Definition date: | 2012-12-12 | | Last modified: | 2012-12-12 |
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 | | PRD_000901 | | Name: | thiomuracin A derivative | | Formula: | C53 H54 N13 O9 S6 | | Definition date: | 2012-12-26 | | Last modified: | 2023-11-03 |
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 | | PRD_000760 | | Name: | THIOPEPTIDE THIOSTREPTON OXIDIZED AT CA-CB BOND OF RESIDUE 9 | | Formula: | C69 H79 N18 O17 S5 | | Description: | THIOSTREPTON IS A HETEROCYCLIC THIOPEPTIDE,
CONSISTING OF FOUR THIAZOLES ONE THIOZOLINE
ONE PIPERIDEINE RINGS.
A MODIFIED QUINOLINE LINKED TO MAIN-CHAIN
RESIDUE 1 AND SIDE-CHAIN OF RESIDUE 12.
IN THIS ENTRY RESIDUE 9 WAS CHEMICALLY MODIFIED: THE
CA-CB BOND WAS OXIDIZED FROM SINGLE TO DOUBLE.
RESIDUE 17 (HET DHA) WAS DELETED. | | Definition date: | 2012-12-12 | | Last modified: | 2023-09-20 |
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 | | PRD_000759 | | Name: | THIOPEPTIDE THIOSTREPTON WITH EPIMER FORM OF RESIDUE 9 | | Formula: | C69 H81 N18 O17 S5 | | Description: | THIOSTREPTON IS A HETEROCYCLIC THIOPEPTIDE,
CONSISTING OF FOUR THIAZOLES ONE THIOZOLINE
ONE PIPERIDEINE RINGS.
A MODIFIED QUINOLINE, RESIDUE 0, IS LINKED TO
MAIN-CHAIN RESIDUE 1 AND SIDE-CHAIN OF RESIDUE 12.
IN THIS ENTRY RESIDUE 9 WAS CHEMICALLY MODIFIED
FROM D-CYS TO L-CYS AND RESIDUE 17 (HET DHA)
WAS DELETED. | | Definition date: | 2012-12-12 | | Last modified: | 2023-09-20 |
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 | | PRD_000758 | | Name: | THIOPEPTIDE THIOSTREPTON REDUCED AT N-CA BOND OF RESIDUE 14 | | Formula: | C72 H86 N19 O18 S5 | | Description: | THIOSTREPTON IS A HETEROCYCLIC THIOPEPTIDE,
CONSISTING OF FOUR THIAZOLES, ONE THIOZOLINE,
ONE PIPERIDEINE RINGS.
A MODIFIED QUINOLINE, RESIDUE 0, IS LINKED TO
MAIN-CHAIN RESIDUE 1 AND SIDE-CHAIN OF RESIDUE 12.
IN THIS ENTRY RESIDUE 14 WAS CHEMICALLY MODIFIED TO
HAVE A SINGLE BOND N-CA. | | Definition date: | 2012-12-12 | | Last modified: | 2023-09-20 |
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 | | PRD_000225 | | Name: | GE2270a | | Formula: | C56 H58 N15 O10 S6 | | Description: | GEA2270A IS A THIOPEPTIDE CONSISTING OF ONE
PYRIDINE, ONE OXAZOLE AND FIVE THIAZOLE RINGS.
THE OBSERVED C-TERMINAL AMINO GROUP NH2(15) IS
LIKELY TO BE A POST-TRANSLATIONAL DECARBOXYLATED
REMNANT OF A SER C-TERMINAL RESIDUE. | | Definition date: | 2012-12-12 | | Last modified: | 2023-09-20 |
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 | | PRD_000223 | | Name: | THIOSTREPTON | | Formula: | C72 H84 N19 O18 S5 | | Description: | Thiostrepton is a hetrocyclic thiopeptide belonging to the
thiocillin family, consisting of four thiazole, one thiozoline and one
piperideine rings. A modified quinoline linked to main-chain residue 1
and side-chain of residue 12. Post translational maturation of
thiazole and oxazole containing antibiotics involves the enzymic
condensation of a Cys or Ser with the alpha-carbonyl of the preceding
amino acid to form a thioether or ether bond, then dehydration to form
a double bond with the alpha-amino nitrogen. Thiazoline or oxazoline
ring are dehydrogenated to form thiazole or oxazole rings. the
pyridinyl involves the cross-linking of a Ser and a Cys-Ser pair
usually separated by 7 or 8 residues along the peptide chain. The Ser
residues are dehydrated to didehydroalanines, then bonded between
their beta carbons. The alpha carbonyl of the Cys condenses with alpha
carbon of the first Ser to form a pyridinyl ring. The ring may be
mutiply dehydrogenated to form a pyridine ring with loss of the amino
nitrogen of the first Ser. The amidation of Ser-17 probably does not
occur by the same mechanism, oxidative cleavage of glycine, as in
eukaryotes. | | Definition date: | 2012-12-12 | | Last modified: | 2023-09-20 |
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 | | PRD_000221 | | Name: | Nosiheptide | | Formula: | C51 H46 N13 O11 S6 | | Description: | NOSIHEPTIDE IS A HETROCYCLIC THIOPEPTIDE, CONSISTING OF FIVE THIAZOLES AND ONE 3-HYDROXYPYRIDINE RINGS. A MODIFIED
INDOLE RING NO1(14) IS LINKED VIA THE SIDE CHAINS OF 3-HYDROXY 3GL(6) AND CYS(8). THE OBSERVED C-TERMINAL AMINO GROUP
NH2(13) IS LIKELY TO BE A POST-TRANSLATIONAL DECARBOXYLATED REMNANT OF A SER C-TERMINAL RESIDUE | | Definition date: | 2012-12-12 | | Last modified: | 2023-09-20 |
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