 | | PRD_001023 | | Name: | (2S,5S,8S,13S,16Z)-5-(cyclohexylmethyl)-3,6,9,15,18-pentaoxo-2-(3-phenylprop-2-en-1-yl)-8-{3-[(pyrazin-2-ylcarbonyl)amino]propyl}-1,4,7,10,14-pentaazacyclooctadec-16-ene-13-carboxamide | | Formula: | C38 H49 N9 O7 | | Definition date: | 2012-12-12 | | Last modified: | 2023-11-03 |
|
 | | PRD_001047 | | Name: | (2E,4E)-N-[(2R,3S)-1-{[(5S,8S,9E)-2,7-dioxo-5-(propan-2-yl)-1,6-diazacyclododec-9-en-8-yl]amino}-3-hydroxy-1-oxobutan-2-yl]dodeca-2,4-dienamide | | Formula: | C29 H48 N4 O5 | | Definition date: | 2012-12-12 | | Last modified: | 2023-11-03 |
|
 | | PRD_001184 | | Name: | Dimethyl FK228 | | Formula: | C26 H42 N4 O6 S2 | | Description: | DIMETHYL FK228 IS THE REDUCED AND MODIFIED FORM OF ROMIDEPSIN. THE DISULFIDE INTRAMOLECULAR LINKAGE OF ROMIDEPSIN IS BROKEN, AND BOTH SULFHYDRYL GROUPS ARE METHYLATED. | | Definition date: | 2014-03-05 | | Last modified: | 2023-11-03 |
|
 | | PRD_001189 | | Name: | ATSP-7041 stapled-peptide | | Formula: | C87 H124 N16 O22 | | Definition date: | 2013-11-20 | | Last modified: | 2023-11-03 |
|
 | | PRD_000428 | | Name: | CYCLOTHEONAMIDE A | | Formula: | C36 H46 N9 O8 | | Definition date: | 2012-12-12 | | Last modified: | 2023-11-03 |
|
 | | PRD_000554 | | Name: | Cyclotheonamide A | | Formula: | C36 H46 N9 O8 | | Definition date: | 2012-02-03 | | Last modified: | 2023-11-03 |
|
 | | PRD_000785 | | Name: | Largazole | | Formula: | C21 H29 N4 O4 S3 | | Definition date: | 2012-12-12 | | Last modified: | 2023-11-03 |
|
 | | PRD_000857 | | Name: | SAH-p53-8 stapled-peptide | | Formula: | C96 H151 N26 O25 | | Definition date: | 2012-12-12 | | Last modified: | 2023-11-03 |
|
 | | PRD_000142 | | Name: | Cyclosporin A | | Formula: | C62 H111 N11 O12 | | Description: | CYCLOSPORIN IS A CYCLIC UNDECAPEPTIDE.
CYCLIZATION IS ACHIEVED BY LINKING THE N- AND
THE C- TERMINI. | | Definition date: | 2012-12-12 | | Last modified: | 2023-09-20 |
|
 | | PRD_000143 | | Name: | Cyclosporin D | | Formula: | C64 H115 N11 O12 S | | Description: | CYCLOSPORIN IS A CYCLIC UNDECAPEPTIDE.
CYCLIZATION IS ACHIEVED BY LINKING THE N- AND
THE C- TERMINI.
CYCLOSPORIN D IS A NATURAL ANALOG OF CYCLOSPORIN A,
OBTAINED FROM A DIFFERENT NUTRIENT BROTH AND
DIFFERS FROM CYCLOSPORIN IN RESIDUE 6 (ABA6VAL). | | Definition date: | 2012-12-12 | | Last modified: | 2023-09-20 |
|
 | | PRD_000144 | | Name: | Cyclosporin C | | Formula: | C62 H111 N11 O13 | | Description: | CYCLOSPORIN C IS A CYCLIC UNDECAPEPTIDE.
CYCLIZATION IS ACHIEVED BY LINKING THE N- AND
THE C- TERMINI.
CYCLOSPORIN C IS A NATURAL ANALOG OF CYCLOSPORIN A,
OBTAINED FROM A DIFFERENT NUTRIENT BROTH AND DIFFERS
FROM CYCLOSPORIN A IN RESIDUE 6 (ABA6THR). | | Definition date: | 2012-12-12 | | Last modified: | 2023-09-20 |
|
 | | PRD_000199 | | Name: | Mersacidin | | Formula: | C80 H120 N20 O21 S4 | | Description: | MERSACIDIN IS A TETRACYCLIC PEPTIDE. POST TRANSLATIONAL MATURATION
OF LANTIBIOTICS INVOLVES THE ENZYMIC CONVERSION OF THR, AND SER INTO
DEHYDRATED AA AND THE FORMATION OF THIOETHER BONDS WITH CYSTEINE. THE
CARBOXY-TERMINAL BETA-METHYLLANTHIONINE UNDERGOES
DECARBOXYLATION. THIOETHER BONDS WITH CYSTEINE RESULT IN FOUR
RINGS. THIS IS FOLLOWED BY MEMBRANE TRANSLOCATION AND CLEAVAGE OF THE
MODIFIED PRECURSOR. | | Definition date: | 2012-12-12 | | Last modified: | 2023-09-20 |
|
 | | PRD_000223 | | Name: | THIOSTREPTON | | Formula: | C72 H84 N19 O18 S5 | | Description: | Thiostrepton is a hetrocyclic thiopeptide belonging to the
thiocillin family, consisting of four thiazole, one thiozoline and one
piperideine rings. A modified quinoline linked to main-chain residue 1
and side-chain of residue 12. Post translational maturation of
thiazole and oxazole containing antibiotics involves the enzymic
condensation of a Cys or Ser with the alpha-carbonyl of the preceding
amino acid to form a thioether or ether bond, then dehydration to form
a double bond with the alpha-amino nitrogen. Thiazoline or oxazoline
ring are dehydrogenated to form thiazole or oxazole rings. the
pyridinyl involves the cross-linking of a Ser and a Cys-Ser pair
usually separated by 7 or 8 residues along the peptide chain. The Ser
residues are dehydrated to didehydroalanines, then bonded between
their beta carbons. The alpha carbonyl of the Cys condenses with alpha
carbon of the first Ser to form a pyridinyl ring. The ring may be
mutiply dehydrogenated to form a pyridine ring with loss of the amino
nitrogen of the first Ser. The amidation of Ser-17 probably does not
occur by the same mechanism, oxidative cleavage of glycine, as in
eukaryotes. | | Definition date: | 2012-12-12 | | Last modified: | 2023-09-20 |
|
 | | PRD_000584 | | Name: | (4R)-3-[(2S,3S)-3-{[(4-amino-2,6-dimethylphenoxy)acetyl]amino}-2-hydroxy-4-phenylbutanoyl]-5,5-dimethyl-N-(2-methylprop
-2-en-1-yl)-1,3-thiazolidine-4-carboxamide | | Formula: | C30 H40 N4 O5 S | | Definition date: | 2012-12-12 | | Last modified: | 2023-09-20 |
|
 | | PRD_000759 | | Name: | THIOPEPTIDE THIOSTREPTON WITH EPIMER FORM OF RESIDUE 9 | | Formula: | C69 H81 N18 O17 S5 | | Description: | THIOSTREPTON IS A HETEROCYCLIC THIOPEPTIDE,
CONSISTING OF FOUR THIAZOLES ONE THIOZOLINE
ONE PIPERIDEINE RINGS.
A MODIFIED QUINOLINE, RESIDUE 0, IS LINKED TO
MAIN-CHAIN RESIDUE 1 AND SIDE-CHAIN OF RESIDUE 12.
IN THIS ENTRY RESIDUE 9 WAS CHEMICALLY MODIFIED
FROM D-CYS TO L-CYS AND RESIDUE 17 (HET DHA)
WAS DELETED. | | Definition date: | 2012-12-12 | | Last modified: | 2023-09-20 |
|
 | | PRD_000760 | | Name: | THIOPEPTIDE THIOSTREPTON OXIDIZED AT CA-CB BOND OF RESIDUE 9 | | Formula: | C69 H79 N18 O17 S5 | | Description: | THIOSTREPTON IS A HETEROCYCLIC THIOPEPTIDE,
CONSISTING OF FOUR THIAZOLES ONE THIOZOLINE
ONE PIPERIDEINE RINGS.
A MODIFIED QUINOLINE LINKED TO MAIN-CHAIN
RESIDUE 1 AND SIDE-CHAIN OF RESIDUE 12.
IN THIS ENTRY RESIDUE 9 WAS CHEMICALLY MODIFIED: THE
CA-CB BOND WAS OXIDIZED FROM SINGLE TO DOUBLE.
RESIDUE 17 (HET DHA) WAS DELETED. | | Definition date: | 2012-12-12 | | Last modified: | 2023-09-20 |
|
 | | PRD_000765 | | Name: | CYCLOSPORIN A, 5 mutation | | Formula: | C63 H113 N11 O12 | | Description: | CYCLOSPORIN IS A CYCLIC UNDECAPEPTIDE.
CYCLIZATION IS ACHIEVED BY LINKING THE N- AND
THE C- TERMINI.
THE CYCLOSPORIN WAS MODIFIED AT POSITION 5 TO BE
4-[(E)-2-BUTENYL]-4,4,N-TRIMETHYL-L-THREONINE | | Definition date: | 2012-12-12 | | Last modified: | 2023-09-20 |
|
 | | PRD_000766 | | Name: | CYCLOSPORIN A, 6 mutation | | Formula: | C63 H113 N11 O13 | | Description: | CYCLOSPORIN IS A CYCLIC UNDECAPEPTIDE.
CYCLIZATION IS ACHIEVED BY LINKING THE N- AND
THE C- TERMINI.
THE CYCLOSPORIN A MOLECULE WAS MODIFIED AT
POSITION 6 TO BE 2-AMINO-5-HYDROXYPENTANOIC ACID | | Definition date: | 2012-12-12 | | Last modified: | 2023-09-20 |
|
 | | PRD_000767 | | Name: | CYCLOSPORIN A, 7 mutation | | Formula: | C63 H113 N11 O13 | | Description: | CYCLOSPORIN IS A CYCLIC UNDECAPEPTIDE.
CYCLIZATION IS ACHIEVED BY LINKING THE N- AND
THE C- TERMINI.
THE CYCLOSPORIN A WAS MODIFIED AT POSITION 7
TO BE N-METHYL-D-SERINE | | Definition date: | 2012-12-12 | | Last modified: | 2023-09-20 |
|
 | | PRD_000768 | | Name: | CYCLOSPORIN A, 8 mutation | | Formula: | C62 H111 N11 O12 | | Description: | CYCLOSPORIN IS A CYCLIC UNDECAPEPTIDE.
CYCLIZATION IS ACHIEVED BY LINKING THE N- AND
THE C- TERMINI.
THE CYCLOSPORIN A MOLECULE WAS MODIFIED AT
POSITION 8 TO BE N-METHYL-ISOLEUCINE | | Definition date: | 2012-12-12 | | Last modified: | 2023-09-20 |
|
 | | PRD_002268 | | Name: | Lipid II | | Formula: | C54 H91 N8 O26 P2 | | Definition date: | 2020-08-19 | | Last modified: | 2023-06-11 |
|
 | | PRD_002441 | | Name: | Myxovalargin B | | Formula: | C80 H136 N21 O17 | | Definition date: | 2023-01-25 | | Last modified: | 2023-05-11 |
|
 | | PRD_002442 | | Name: | Myxovalargin A | | Formula: | C81 H138 N21 O17 | | Definition date: | 2023-01-18 | | Last modified: | 2023-05-11 |
|
 | | PRD_002419 | | Name: | Cyclomarin A | | Formula: | C56 H82 N8 O11 | | Definition date: | 2023-03-29 | | Last modified: | 2023-03-29 |
|
 | | PRD_900007 | | Name: | ALPHA-ACARBOSE | | Formula: | C25 H43 N O18 | | Description: | oligosaccharide | | Definition date: | 2020-07-29 | | Last modified: | 2020-07-29 |
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