 | | PRD_000976 | | Name: | N-acetyl-L-valyl-L-alpha-glutamyl-N-[(2S)-1-carboxy-3-oxopropan-2-yl]-L-isoleucinamide | | Formula: | C22 H36 N4 O9 | | Definition date: | 2012-12-12 | | Last modified: | 2013-06-03 |
|
 | | PRD_000210 | | Name: | Teicoplanin Aglycone | | Formula: | C58 H45 Cl2 N7 O18 | | Description: | TEICOPLANIN AGLYCON IS THE NONSUGAR COMPONENT OF
TEICOPLANIN, CONSISTING OF THE TETRACYCLIC
HEPTAPEPTIDE ONLY. | | Definition date: | 2012-12-12 | | Last modified: | 2023-09-20 |
|
 | | PRD_000977 | | Name: | 1-acetyl-L-prolyl-L-threonyl-N-[(2R,3S)-4-chloro-3-hydroxy-1-(4-hydroxyphenyl)butan-2-yl]-L-serinamide | | Formula: | C24 H35 Cl N4 O8 | | Definition date: | 2012-12-12 | | Last modified: | 2013-06-03 |
|
 | | PRD_000211 | | Name: | A40926 | | Formula: | C88 H95 Cl2 N9 O34 | | Definition date: | 2012-12-12 | | Last modified: | 2023-09-20 |
|
 | | PRD_000212 | | Name: | Microcystin LR | | Formula: | C49 H75 N10 O12 | | Definition date: | 2012-12-12 | | Last modified: | 2023-11-03 |
|
 | | PRD_000980 | | Name: | N-[(S)-({[(benzyloxy)carbonyl]amino}methyl)(hydroxy)phosphoryl]-N-methyl-L-leucinamide | | Formula: | C16 H26 N3 O5 P | | Definition date: | 2012-12-12 | | Last modified: | 2012-12-12 |
|
 | | PRD_000981 | | Name: | N-[(S)-({[(benzyloxy)carbonyl]amino}methyl)(hydroxy)phosphoryl]-L-leucyl-L-alanine | | Formula: | C18 H28 N3 O7 P | | Definition date: | 2012-12-12 | | Last modified: | 2012-12-12 |
|
 | | PRD_000213 | | Name: | motuporin | | Formula: | C40 H57 N5 O10 | | Definition date: | 2012-12-12 | | Last modified: | 2023-11-03 |
|
 | | PRD_000982 | | Name: | (2S)-2-({N-[(R)-({[(benzyloxy)carbonyl]amino}methyl)(hydroxy)phosphoryl]-L-leucyl}amino)butanoic acid | | Formula: | C19 H30 N3 O7 P | | Definition date: | 2012-12-12 | | Last modified: | 2012-12-12 |
|
 | | PRD_000214 | | Name: | NODULARIN-R | | Formula: | C41 H61 N8 O10 | | Definition date: | 2012-12-12 | | Last modified: | 2023-11-03 |
|
 | | PRD_000215 | | Name: | DIHYDROMICROCYSTIN-LA | | Formula: | C46 H69 N7 O12 | | Definition date: | 2012-12-12 | | Last modified: | 2023-11-03 |
|
 | | PRD_000983 | | Name: | N-[(R)-({[(benzyloxy)carbonyl]amino}methyl)(hydroxy)phosphoryl]-L-leucyl-L-norvaline | | Formula: | C20 H32 N3 O7 P | | Definition date: | 2012-12-12 | | Last modified: | 2012-12-12 |
|
 | | PRD_000216 | | Name: | LEUPEPTIN | | Formula: | C20 H41 N6 O5 | | Definition date: | 2012-12-12 | | Last modified: | 2023-09-20 |
|
 | | PRD_000984 | | Name: | N-[(S)-({[(benzyloxy)carbonyl]amino}methyl)(hydroxy)phosphoryl]-L-leucyl-L-isoleucine | | Formula: | C21 H34 N3 O7 P | | Definition date: | 2012-12-12 | | Last modified: | 2012-12-12 |
|
 | | PRD_000985 | | Name: | N-[(R)-({[(benzyloxy)carbonyl]amino}methyl)(hydroxy)phosphoryl]-N-ethyl-L-leucinamide | | Formula: | C17 H28 N3 O5 P | | Definition date: | 2012-12-12 | | Last modified: | 2012-12-12 |
|
 | | PRD_000217 | | Name: | Daptomycin | | Formula: | C72 H101 N17 O26 | | Description: |
DAPTOMYCIN IS AN ACIDIC CYCLIC LIPOPEPTIDE.
THE SCAFFOLD IS MADE OF TWO PARTS:
(1) THREE RESIDUES N-TERM EXOCYCLIC PART
(2) A DECAPEPTIDE LACTONE RING DERIVED FROM
CYCLISATION OF THR3 SIDE CHAIN ONTO THE C-TER
CARBOXYL GROUP
THE N-DECANOYL FATTY ACID IS LINKED TO THE
MAIN BODY OF THE MOLECULE VIA N-TERM ACYLATION. | | Definition date: | 2012-12-12 | | Last modified: | 2023-09-20 |
|
 | | PRD_000986 | | Name: | N-[(R)-({[(benzyloxy)carbonyl]amino}methyl)(hydroxy)phosphoryl]-L-leucylglycine | | Formula: | C17 H26 N3 O7 P | | Definition date: | 2012-12-12 | | Last modified: | 2012-12-12 |
|
 | | PRD_000219 | | Name: | GRAMICIDIN S | | Formula: | C60 H92 N12 O10 | | Description: | GRAMICIDIN S IS A DECAPEPTIDE,
RESIDUES 1 AND 10 FORM A PEPTIDE BOND
RESULTING IN CYCLIZATION. | | Definition date: | 2012-12-12 | | Last modified: | 2023-09-20 |
|
 | | PRD_000220 | | Name: | FEGLYMYCIN | | Formula: | C95 H97 N13 O30 | | Description: | FEGLYMYCIN IS A LINEAR HELICAL TRIDECAMER PEPTIDE | | Definition date: | 2012-12-12 | | Last modified: | 2023-09-20 |
|
 | | PRD_000987 | | Name: | N-[(S)-({[(benzyloxy)carbonyl]amino}methyl)(hydroxy)phosphoryl]-L-leucyl-L-valine | | Formula: | C20 H32 N3 O7 P | | Definition date: | 2012-12-12 | | Last modified: | 2012-12-12 |
|
 | | PRD_000221 | | Name: | Nosiheptide | | Formula: | C51 H46 N13 O11 S6 | | Description: | NOSIHEPTIDE IS A HETROCYCLIC THIOPEPTIDE, CONSISTING OF FIVE THIAZOLES AND ONE 3-HYDROXYPYRIDINE RINGS. A MODIFIED
INDOLE RING NO1(14) IS LINKED VIA THE SIDE CHAINS OF 3-HYDROXY 3GL(6) AND CYS(8). THE OBSERVED C-TERMINAL AMINO GROUP
NH2(13) IS LIKELY TO BE A POST-TRANSLATIONAL DECARBOXYLATED REMNANT OF A SER C-TERMINAL RESIDUE | | Definition date: | 2012-12-12 | | Last modified: | 2023-09-20 |
|
 | | PRD_000988 | | Name: | N-benzoyl-L-norleucyl-6-ammonio-L-norleucyl-N~5~-[amino(iminio)methyl]-N-[(2S)-5-carbamimidamido-1-hydroxypentan-2-yl]-L-ornithinamide | | Formula: | C31 H57 N11 O5 | | Definition date: | 2012-12-12 | | Last modified: | 2023-11-03 |
|
 | | PRD_000222 | | Name: | RAMOPLANIN A2 | | Formula: | C119 H154 Cl N21 O40 | | Description: | RAMOPLANIN A2 IS A CYCLIC HEPTADECAMER
LIPOGLYCODEPSIPEPTIDE.
THE SCAFFOLD IS A HEPTA CYCLIC PEPTIDE
GLYCOSYLATED BY ONE DISACCHARIDE AND A FATTY ACID
AT THE N-TERM. | | Definition date: | 2012-12-12 | | Last modified: | 2023-09-20 |
|
 | | PRD_000989 | | Name: | ISOAMYLPHOSPHONYL-GLY-PRO-ALA | | Formula: | C15 H28 N3 O6 P | | Definition date: | 2012-12-12 | | Last modified: | 2013-06-03 |
|
 | | PRD_000223 | | Name: | THIOSTREPTON | | Formula: | C72 H84 N19 O18 S5 | | Description: | Thiostrepton is a hetrocyclic thiopeptide belonging to the
thiocillin family, consisting of four thiazole, one thiozoline and one
piperideine rings. A modified quinoline linked to main-chain residue 1
and side-chain of residue 12. Post translational maturation of
thiazole and oxazole containing antibiotics involves the enzymic
condensation of a Cys or Ser with the alpha-carbonyl of the preceding
amino acid to form a thioether or ether bond, then dehydration to form
a double bond with the alpha-amino nitrogen. Thiazoline or oxazoline
ring are dehydrogenated to form thiazole or oxazole rings. the
pyridinyl involves the cross-linking of a Ser and a Cys-Ser pair
usually separated by 7 or 8 residues along the peptide chain. The Ser
residues are dehydrated to didehydroalanines, then bonded between
their beta carbons. The alpha carbonyl of the Cys condenses with alpha
carbon of the first Ser to form a pyridinyl ring. The ring may be
mutiply dehydrogenated to form a pyridine ring with loss of the amino
nitrogen of the first Ser. The amidation of Ser-17 probably does not
occur by the same mechanism, oxidative cleavage of glycine, as in
eukaryotes. | | Definition date: | 2012-12-12 | | Last modified: | 2023-09-20 |
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