4KQX
Mutant Slackia exigua KARI DDV in complex with NAD and an inhibitor
Summary for 4KQX
| Entry DOI | 10.2210/pdb4kqx/pdb |
| Related | 4KQW |
| Descriptor | Ketol-acid reductoisomerase, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, N-HYDROXY-N-ISOPROPYLOXAMIC ACID, ... (6 entities in total) |
| Functional Keywords | cofactor switch, rossmann fold, ketol-acid reductoisomerase, acetohydroxyacid isomeroreductase, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor |
| Biological source | Slackia exigua |
| Total number of polymer chains | 2 |
| Total formula weight | 79883.93 |
| Authors | Brinkmann-Chen, S.,Flock, T.,Cahn, J.K.B.,Snow, C.D.,Brustad, E.M.,Mcintosh, J.A.,Meinhold, P.,Zhang, L.,Arnold, F.H. (deposition date: 2013-05-15, release date: 2013-06-26, Last modification date: 2023-09-20) |
| Primary citation | Brinkmann-Chen, S.,Flock, T.,Cahn, J.K.,Snow, C.D.,Brustad, E.M.,McIntosh, J.A.,Meinhold, P.,Zhang, L.,Arnold, F.H. General approach to reversing ketol-acid reductoisomerase cofactor dependence from NADPH to NADH. Proc.Natl.Acad.Sci.USA, 110:10946-10951, 2013 Cited by PubMed: 23776225DOI: 10.1073/pnas.1306073110 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.8 Å) |
Structure validation
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