3G0B
Crystal structure of dipeptidyl peptidase IV in complex with TAK-322
Summary for 3G0B
| Entry DOI | 10.2210/pdb3g0b/pdb |
| Related | 3G0C 3G0D 3G0G |
| Descriptor | Dipeptidyl peptidase 4, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (5 entities in total) |
| Functional Keywords | protease and 8-bladed beta-propeller domain, aminopeptidase, cell membrane, glycoprotein, hydrolase, membrane, protease, secreted, serine protease, signal-anchor, transmembrane, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
| Biological source | Homo sapiens (Human) |
| Total number of polymer chains | 4 |
| Total formula weight | 351617.09 |
| Authors | Zhang, Z.,Wallace, M.B.,Feng, J.,Stafford, J.A.,Kaldor, S.W.,Shi, L.,Skene, R.J.,Aertgeerts, K.,Lee, B.,Jennings, A.,Xu, R.,Kassel, D.,Webb, D.R.,Gwaltney, S.L. (deposition date: 2009-01-27, release date: 2010-02-16, Last modification date: 2020-07-29) |
| Primary citation | Zhang, Z.,Wallace, M.B.,Feng, J.,Stafford, J.A.,Skene, R.J.,Shi, L.,Lee, B.,Aertgeerts, K.,Jennings, A.,Xu, R.,Kassel, D.B.,Kaldor, S.W.,Navre, M.,Webb, D.R.,Gwaltney, S.L. Design and Synthesis of Pyrimidinone and Pyrimidinedione Inhibitors of Dipeptidyl Peptidase IV. J.Med.Chem., 54:510-524, 2011 Cited by PubMed: 21186796DOI: 10.1021/jm101016w PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.25 Å) |
Structure validation
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