3ERT
HUMAN ESTROGEN RECEPTOR ALPHA LIGAND-BINDING DOMAIN IN COMPLEX WITH 4-HYDROXYTAMOXIFEN
Replaces: 2ERTSummary for 3ERT
Entry DOI | 10.2210/pdb3ert/pdb |
Descriptor | PROTEIN (ESTROGEN RECEPTOR ALPHA), 4-HYDROXYTAMOXIFEN (3 entities in total) |
Functional Keywords | nuclear receptor, transcription factor, estrogen, antagonist |
Biological source | Homo sapiens (human) |
Cellular location | Isoform 1: Nucleus. Isoform 3: Nucleus: P03372 |
Total number of polymer chains | 1 |
Total formula weight | 30237.73 |
Authors | Shiau, A.K.,Barstad, D.,Loria, P.M.,Cheng, L.,Kushner, P.J.,Agard, D.A.,Greene, G.L. (deposition date: 1999-03-30, release date: 1999-04-08, Last modification date: 2023-09-06) |
Primary citation | Shiau, A.K.,Barstad, D.,Loria, P.M.,Cheng, L.,Kushner, P.J.,Agard, D.A.,Greene, G.L. The structural basis of estrogen receptor/coactivator recognition and the antagonism of this interaction by tamoxifen. Cell(Cambridge,Mass.), 95:927-937, 1998 Cited by PubMed: 9875847DOI: 10.1016/S0092-8674(00)81717-1 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.9 Å) |
Structure validation
Download full validation report