3CYU
Human Carbonic Anhydrase II complexed with Cryptophane biosensor and xenon
Summary for 3CYU
| Entry DOI | 10.2210/pdb3cyu/pdb |
| Descriptor | Carbonic anhydrase 2, ZINC ION, MoMo-2-[4-(2-(4-(methoxy)-1H-1,2,3-triazol-1-yl)ethyl)benzenesulfonamide]-7,12-bis-[3-(4-(methoxy)-1H-1,2,3-triazol-1-y l)propanoic acid]-cryptophane-A, ... (6 entities in total) |
| Functional Keywords | zinc metalloenzyme, sulfonamide, cryptophane, xenon, biosensor, disease mutation, lyase, metal-binding |
| Biological source | Homo sapiens (human) |
| Cellular location | Cytoplasm: P00918 |
| Total number of polymer chains | 1 |
| Total formula weight | 32464.06 |
| Authors | Aaron, J.A.,Jude, K.M.,Di Costanzo, L.,Christianson, D.W. (deposition date: 2008-04-26, release date: 2008-05-27, Last modification date: 2023-08-30) |
| Primary citation | Aaron, J.A.,Chambers, J.M.,Jude, K.M.,Di Costanzo, L.,Dmochowski, I.J.,Christianson, D.W. Structure of a 129Xe-cryptophane biosensor complexed with human carbonic anhydrase II. J.Am.Chem.Soc., 130:6942-6943, 2008 Cited by PubMed Abstract: Cryptophanes represent an exciting class of xenon-encapsulating molecules that can be exploited as probes for nuclear magnetic resonance imaging. The 1.70 A resolution crystal structure of a cryptophane-derivatized benezenesulfonamide complexed with human carbonic anhydrase II shows how an encapsulated xenon atom can be directed to a specific biological target. The crystal structure confirms binding measurements indicating that the cryptophane cage does not strongly interact with the surface of the protein, which may enhance the sensitivity of 129Xe NMR spectroscopic measurements in solution. PubMed: 18461940DOI: 10.1021/ja802214x PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.7 Å) |
Structure validation
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