2KH2
Solution structure of a scFv-IL-1B complex
Summary for 2KH2
Entry DOI | 10.2210/pdb2kh2/pdb |
Descriptor | Interleukin-1 beta, scFv (2 entities in total) |
Functional Keywords | scfv, single chain fv, il-1b, antibody, cytokine, inflammatory response, mitogen, pyrogen, secreted, cytokine-immune system complex, cytokine/immune system |
Biological source | Homo sapiens (human) More |
Cellular location | Secreted: P01584 |
Total number of polymer chains | 2 |
Total formula weight | 44789.14 |
Authors | Wilkinson, I.C.,Hall, C.J.,Veverka, V.,Muskett, F.W.,Stephens, P.E.,Taylor, R.J.,Henry, A.J.,Carr, M.D. (deposition date: 2009-03-23, release date: 2009-09-08, Last modification date: 2022-03-16) |
Primary citation | Wilkinson, I.C.,Hall, C.J.,Veverka, V.,Shi, J.Y.,Muskett, F.W.,Stephens, P.E.,Taylor, R.J.,Henry, A.J.,Carr, M.D. High resolution NMR-based model for the structure of a scFv-IL-1beta complex: potential for NMR as a key tool in therapeutic antibody design and development. J.Biol.Chem., 284:31928-31935, 2009 Cited by PubMed: 19776018DOI: 10.1074/jbc.M109.025304 PDB entries with the same primary citation |
Experimental method | SOLUTION NMR |
Structure validation
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