2HBQ
Crystal structure of wildtype human caspase-1 in complex with 3-[2-(2-benzyloxycarbonylamino-3-methyl-butyrylamino)-propionylamino]-4-oxo-pentanoic acid (z-VAD-FMK)
Replaces: 2FQRSummary for 2HBQ
Entry DOI | 10.2210/pdb2hbq/pdb |
Related | 1SC1 1SC3 1SC4 2FQQ 2HBR 2HBY 2HBZ |
Related PRD ID | PRD_000338 |
Descriptor | Caspase-1, N-[(benzyloxy)carbonyl]-L-valyl-N-[(2S)-1-carboxy-4-fluoro-3-oxobutan-2-yl]-L-alaninamide, ... (4 entities in total) |
Functional Keywords | active-site inhibitor, allosteric circuit, hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Homo sapiens (human) More |
Cellular location | Cytoplasm: P29466 P29466 |
Total number of polymer chains | 3 |
Total formula weight | 30600.50 |
Authors | Scheer, J.M.,Wells, J.A.,Romanowski, M.J. (deposition date: 2006-06-14, release date: 2006-06-27, Last modification date: 2023-08-30) |
Primary citation | Scheer, J.M.,Romanowski, M.J.,Wells, J.A. A Common Allosteric Site and Mechanism in Caspases Proc.Natl.Acad.Sci.USA, 103:7595-7600, 2006 Cited by PubMed: 16682620DOI: 10.1073/pnas.0602571103 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.8 Å) |
Structure validation
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