1SGZ

Crystal Structure of Unbound Beta-Secretase Catalytic Domain.

Summary for 1SGZ

Entry DOI	10.2210/pdb1sgz/pdb
Related	1FKN 1M4H
Descriptor	Beta-secretase (2 entities in total)
Functional Keywords	beta-secretase, memapsin, bace, aspartic protease, protease flap, drug design, asp2, alzheimer's disease, hydrolase
Biological source	Homo sapiens (human)
Cellular location	Membrane; Single-pass type I membrane protein: P56817
Total number of polymer chains	4
Total formula weight	173251.22
Authors	Hong, L.,Tang, J. (deposition date: 2004-02-24, release date: 2004-05-04, Last modification date: 2023-08-23)
Primary citation	Hong, L.,Tang, J. Flap Position of Free Memapsin 2 (beta-Secretase), a Model for Flap Opening in Aspartic Protease Catalysis Biochemistry, 43:4689-4695, 2004 Cited by PubMed: 15096037 DOI: 10.1021/bi0498252 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2 Å)

Structure validation