1NIH

Structure of deoxy-quaternary haemoglobin with liganded beta subunits

Summary for 1NIH

Entry DOI	10.2210/pdb1nih/pdb
Descriptor	HEMOGLOBIN (NICKELOUS DEOXY) (ALPHA CHAIN), HEMOGLOBIN (FERROUS CARBONMONOXY) (BETA CHAIN), PROTOPORPHYRIN IX CONTAINING NI(II), ... (7 entities in total)
Functional Keywords	oxygen transport
Biological source	Homo sapiens (human) More
Total number of polymer chains	4
Total formula weight	65268.80
Authors	Luisi, B.,Liddington, B. (deposition date: 1990-03-14, release date: 1992-10-15, Last modification date: 2024-02-14)
Primary citation	Luisi, B.,Liddington, B.,Fermi, G.,Shibayama, N. Structure of deoxy-quaternary haemoglobin with liganded beta subunits. J.Mol.Biol., 214:7-14, 1990 Cited by PubMed Abstract: We have determined the structure of a T-state haemoglobin in which the haem groups of the beta subunits have carbon monoxide bound, and the alpha subunits have nickel replacing the haem iron and are ligand-free. The structural adjustments on binding ligand in the T state are in the same direction as those associated with the quaternary transition, and a translational shift of the haem is severely restricted. We explain how these observations may account for the low ligand affinity of the beta haem of T-state haemoglobin. PubMed: 2370669 DOI: 10.1016/0022-2836(90)90139-D PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.6 Å)

Structure validation