1HXW

HIV-1 PROTEASE DIMER COMPLEXED WITH A-84538

Summary for 1HXW

Entry DOI	10.2210/pdb1hxw/pdb
Related PRD ID	PRD_001001
Descriptor	HIV-1 PROTEASE, RITONAVIR (3 entities in total)
Functional Keywords	aspartyl protease, hydrolase, aspartic proteinase, hiv, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological source	Human immunodeficiency virus 1
Cellular location	Matrix protein p17: Virion (Potential). Capsid protein p24: Virion (Potential). Nucleocapsid protein p7: Virion (Potential). Reverse transcriptase/ribonuclease H: Virion (Potential). Integrase: Virion (Potential): P12499
Total number of polymer chains	2
Total formula weight	22382.51
Authors	Park, C.H.,Nienaber, V.,Kong, X.P. (deposition date: 1997-01-24, release date: 1998-02-04, Last modification date: 2024-02-07)
Primary citation	Kempf, D.J.,Marsh, K.C.,Denissen, J.F.,McDonald, E.,Vasavanonda, S.,Flentge, C.A.,Green, B.E.,Fino, L.,Park, C.H.,Kong, X.P. ABT-538 is a potent inhibitor of human immunodeficiency virus protease and has high oral bioavailability in humans. Proc.Natl.Acad.Sci.USA, 92:2484-2488, 1995 Cited by PubMed: 7708670 DOI: 10.1073/pnas.92.7.2484 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.8 Å)

Structure validation