1HWH
1:1 COMPLEX OF HUMAN GROWTH HORMONE MUTANT G120R WITH ITS SOLUBLE BINDING PROTEIN
Summary for 1HWH
| Entry DOI | 10.2210/pdb1hwh/pdb |
| Descriptor | GROWTH HORMONE, GROWTH HORMONE BINDING PROTEIN (2 entities in total) |
| Functional Keywords | cytokine, hormone, receptor, hematopoietic, complex (hormone-receptor), complex (hormone-receptor) complex, complex (hormone/receptor) |
| Biological source | Homo sapiens (human) More |
| Cellular location | Secreted: P01241 Cell membrane; Single-pass type I membrane protein. Isoform 2: Cell membrane; Single-pass type I membrane protein. Growth hormone-binding protein: Secreted: P10912 |
| Total number of polymer chains | 2 |
| Total formula weight | 49533.78 |
| Authors | Sundstrom, S.M.,Lundqvist, T. (deposition date: 1996-11-13, release date: 1997-11-19, Last modification date: 2021-11-03) |
| Primary citation | Sundstrom, M.,Lundqvist, T.,Rodin, J.,Giebel, L.B.,Milligan, D.,Norstedt, G. Crystal structure of an antagonist mutant of human growth hormone, G120R, in complex with its receptor at 2.9 A resolution. J.Biol.Chem., 271:32197-32203, 1996 Cited by PubMed: 8943276DOI: 10.1074/jbc.271.50.32197 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.9 Å) |
Structure validation
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