1E4E

D-alanyl-D-lacate ligase

Summary for 1E4E

Entry DOI	10.2210/pdb1e4e/pdb
Related	1IOV 1IOW
Descriptor	VANCOMYCIN/TEICOPLANIN A-TYPE RESISTANCE PROTEIN VANA, ADENOSINE-5'-DIPHOSPHATE, 1(S)-AMINOETHYL-(2-CARBOXYPROPYL)PHOSPHORYL-PHOSPHINIC ACID, ... (8 entities in total)
Functional Keywords	ligase, cell wall, antibiotic resistance, membrane, peptidoglycan synthesis
Biological source	ENTEROCOCCUS FAECIUM More
Total number of polymer chains	2
Total formula weight	78272.58
Authors	Roper, D.I. (deposition date: 2000-07-03, release date: 2001-06-28, Last modification date: 2023-12-13)
Primary citation	Roper, D.I.,Huyton, T.,Vagin, A.,Dodson, G. The molecular basis of vancomycin resistance in clinically relevant Enterococci: crystal structure of D-alanyl-D-lactate ligase (VanA). Proc. Natl. Acad. Sci. U.S.A., 97:8921-8925, 2000 Cited by PubMed: 10908650 DOI: 10.1073/pnas.150116497 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.5 Å)

Structure validation