1BX6
CRYSTAL STRUCTURE OF THE POTENT NATURAL PRODUCT INHIBITOR BALANOL IN COMPLEX WITH THE CATALYTIC SUBUNIT OF CAMP-DEPENDENT PROTEIN KINASE
Summary for 1BX6
Entry DOI | 10.2210/pdb1bx6/pdb |
Descriptor | CAMP-DEPENDENT PROTEIN KINASE, BALANOL (3 entities in total) |
Functional Keywords | serine/threonine-protein kinase, balanol, conformational changes, inhibition, protein kinase pka, serine-threonine-protein kinase complex |
Biological source | Mus musculus (house mouse) |
Cellular location | Cytoplasm (By similarity): P05132 |
Total number of polymer chains | 1 |
Total formula weight | 41287.81 |
Authors | Narayana, N.,Xuong, N.-H.,Ten Eyck, L.F.,Taylor, S.S. (deposition date: 1998-10-13, release date: 1999-04-27, Last modification date: 2023-08-09) |
Primary citation | Narayana, N.,Diller, T.C.,Koide, K.,Bunnage, M.E.,Nicolaou, K.C.,Brunton, L.L.,Xuong, N.H.,Ten Eyck, L.F.,Taylor, S.S. Crystal structure of the potent natural product inhibitor balanol in complex with the catalytic subunit of cAMP-dependent protein kinase. Biochemistry, 38:2367-2376, 1999 Cited by PubMed: 10029530DOI: 10.1021/bi9820659 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.1 Å) |
Structure validation
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