1B98
NEUROTROPHIN 4 (HOMODIMER)
Summary for 1B98
Entry DOI | 10.2210/pdb1b98/pdb |
Descriptor | PROTEIN (NEUROTROPHIN-4), CHLORIDE ION (3 entities in total) |
Functional Keywords | target-derived survival factor, neurotrophin 4, neurotrophin 5, hormone-growth factor complex, hormone/growth factor |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 2 |
Total formula weight | 27924.75 |
Authors | Robinson, R.C.,Radziejewski, C.,Stuart, D.I.,Jones, E.Y.,Choe, S. (deposition date: 1999-02-22, release date: 1999-02-26, Last modification date: 2024-10-30) |
Primary citation | Robinson, R.C.,Radziejewski, C.,Spraggon, G.,Greenwald, J.,Kostura, M.R.,Burtnick, L.D.,Stuart, D.I.,Choe, S.,Jones, E.Y. The structures of the neurotrophin 4 homodimer and the brain-derived neurotrophic factor/neurotrophin 4 heterodimer reveal a common Trk-binding site. Protein Sci., 8:2589-2597, 1999 Cited by PubMed Abstract: The neurotrophins are growth factors that are involved in the development and survival of neurons. Neurotrophin release by a target tissue results in neuron growth along the neurotrophin concentration gradient, culminating in the eventual innervation of the target tissue. These activities are mediated through trk cell surface receptors. We have determined the structures of the heterodimer formed between brain-derived neurotrophic factor (BDNF) and neurotrophin 4 (NT4), as well as the structure of homodimer of NT4. We also present the structure of the Neurotrophin 3 homodimer, which is refined to higher resolution than previously published. These structures provide the first views of the architecture of the NT4 protomer. Comparison of the surface of a model of the BDNF homodimer with the structures of the neurotrophin homodimers reveals common features that may be important in the binding between the neurotrophins and their receptors. In particular, there exists an analogous region on the surface of each neurotrophin that is likely to be involved in trk receptor binding. Variations in sequence on the periphery of this common region serve to confer trk receptor specificity. PubMed: 10631974PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.75 Å) |
Structure validation
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