9YVM

Cryo-EM structure of the human TRPM4 channel in an open state bound to NC1 and PI(4,5)P2 in the presence of EGTA.

This is a non-PDB format compatible entry.

Summary for 9YVM

• Entry DOI: 10.2210/pdb9yvm/pdb
• EMDB information: 73528
• Descriptor: Transient receptor potential cation channel subfamily M member 4, [(2R)-1-octadecanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phospho ryl]oxy-propan-2-yl] (8Z)-icosa-5,8,11,14-tetraenoate, Necrocide 1 (3 entities in total)
• Functional Keywords: trpm4, ion channel, transport protein
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 4
• Total formula weight: 550711.65

Authors

Teixeira-Duarte, C.M.,Jiang, Y. (deposition date: 2025-10-23, release date: 2026-07-01)

• Primary citation: Teixeira-Duarte, C.M.,Fu, W.,Zeng, W.,Wang, J.,Jiang, X.,Zhao, Z.,Zhong, Q.,Jiang, Y.; Structural mechanism of Necrocide 1 activation of human TRPM4 that triggers necrosis by sodium overload; Nat Commun, 2026; DOI: 10.1038/s41467-026-74814-2

Experimental method

ELECTRON MICROSCOPY (2.73 Å)