9Y76

Crystal structure of the human DCAF1 WDR domain in complex with OICR-40120

This is a non-PDB format compatible entry.

Summary for 9Y76

• Entry DOI: 10.2210/pdb9y76/pdb
• Descriptor: DDB1- and CUL4-associated factor 1, (4P,5M)-N-[(1S)-3-amino-1-(3-chloro-4-fluorophenyl)-3-oxopropyl]-4-(4-chloro-2-fluorophenyl)-5-{1-[2-(morpholin-4-yl)ethyl]-1H-pyrazol-4-yl}-1H-pyrrole-3-carboxamide, UNKNOWN LIGAND, ... (4 entities in total)
• Functional Keywords: wd-repeat, wdr, dcaf1, sgc, protein transport
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 2
• Total formula weight: 72438.85

Authors

kimani, S.,Dong, A.,Li, Y.,Seitova, A.,Mamai, A.,Al-awar, R.,Ackloo, S.,Arrowsmith, C.H.,Edwards, A.M.,Halabelian, L.,Structural Genomics Consortium (SGC) (deposition date: 2025-09-09, release date: 2025-10-15)

• Primary citation: kimani, S.,Dong, A.,Li, Y.,Seitova, A.,Mamai, A.,Al-awar, R.,Ackloo, S.,Arrowsmith, C.H.,Edwards, A.M.,Halabelian, L.,Structural Genomics Consortium (SGC); Crystal structure of the human DCAF1 WDR domain in complex with OICR-40120; To be published,

Experimental method

X-RAY DIFFRACTION (1.56 Å)