9Y42

Structure of naked mole-rat ribosome with P/E tRNA and eEF2 (rotated)

これはPDB形式変換不可エントリーです。

9Y42 の概要

• エントリーDOI: 10.2210/pdb9y42/pdb
• EMDBエントリー: 72469
• 分子名称: Large ribosomal subunit protein uL2, 60S ribosomal protein L10, Large ribosomal subunit protein uL5, ... (87 entities in total)
• 機能のキーワード: naked mole rat ribosome, ribosome
• 由来する生物種: Heterocephalus glaber; 詳細
• タンパク質・核酸の鎖数: 84
• 化学式量合計: 3382566.74

構造登録者

Gutierrez-Vargas, C.,De, S.,Maji, S.,Liu, Z.,Nieb, M.,Seluanov, A.,Gorbunova, V.,Frank, J. (登録日: 2025-09-02, 公開日: 2026-02-18)

主引用文献

Gutierrez-Vargas, C.,De, S.,Maji, S.,Liu, Z.,Ke, Z.,Niess, M.,Seluanov, A.,Gorbunova, V.,Frank, J.
Structures of naked mole-rat, tuco-tuco, and guinea pig ribosomes-is rRNA fragmentation linked to translational fidelity?
Nucleic Acids Res., 54:-, 2026

PubMed Abstract: Ribosomes are central to protein synthesis in all organisms. In mammals, the ribosome functional core is highly conserved. Remarkably, two rodent species, the naked mole-rat (NMR) and tuco-tuco, display fragmented 28S ribosomal RNA (rRNA), coupled with high translational fidelity and long lifespan. The unusual ribosomal architecture in the NMR and tuco-tuco has been speculated to be linked to high translational fidelity. Here, we show, by single-particle cryo-electron microscopy, that despite the fragmentation of their rRNA, NMR and tuco-tuco ribosomes retain their core functional architecture. Compared to ribosomes of the guinea pig, a phylogenetically related rodent without 28S rRNA fragmentation, ribosomes of NMR and tuco-tuco exhibit poorly resolved density for certain expansion segments. In contrast, the structure of the guinea pig ribosome shows high similarity to the human ribosome. Enhanced translational fidelity in the NMR and tuco-tuco may stem from subtle, allosteric effects in dynamics, linked to rRNA fragmentation.

PubMed: 41603730
DOI: 10.1093/nar/gkag006

実験手法

ELECTRON MICROSCOPY (5 Å)