9UKO

CryoEM structure of the T.thermophilus transcription initiation complex bound to Ap4A-C, -1 dA in the template DNA strand

Summary for 9UKO

• Entry DOI: 10.2210/pdb9uko/pdb
• Related: 9V4M
• EMDB information: 64251
• Descriptor: DNA-directed RNA polymerase subunit alpha, ZINC ION, CYTIDINE-5'-MONOPHOSPHATE, ... (12 entities in total)
• Functional Keywords: complex, transcription
• Biological source: Thermus thermophilus HB8; More
• Total number of polymer chains: 8
• Total formula weight: 460718.80

Authors

Duan, W.,Kaushik, A.,Serganov, A. (deposition date: 2025-04-18, release date: 2025-10-22)

• Primary citation: Duan, W.,Kaushik, A.,Unarta, I.C.,Wu, Y.,Liu, M.M.J.,Weaver, J.W.,Wang, B.,Rice, W.J.,Luciano, D.J.,Belasco, J.G.,Huang, X.,Nudler, E.,Serganov, A.; Molecular basis for noncanonical transcription initiation from Np4A alarmones; Nat.Chem.Biol., 2025; DOI: 10.1038/s41589-025-02044-6

Experimental method

ELECTRON MICROSCOPY (2.89 Å)