9TCB

Catalytic domain of human PARP15 in complex with BAD

Summary for 9TCB

• Entry DOI: 10.2210/pdb9tcb/pdb
• Descriptor: Protein mono-ADP-ribosyltransferase PARP15, [(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl [(2R,3S,4R,5S)-5-(3-carbamoylphenyl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl dihydrogen diphosphate (non-preferred name), NICOTINAMIDE, ... (4 entities in total)
• Functional Keywords: adp-ribosylation, adp-ribosyltransferase, artd, parp, transferase
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 2
• Total formula weight: 46720.13

Authors

Paakkonen, J.,Lehtio, L. (deposition date: 2025-11-21, release date: 2026-01-28)

• Primary citation: Tuovinen, A.,Paakkonen, J.,Maksimainen, M.M.,Hirschen, L.,Hentila, H.I.,Tauscher, M.,Luscher, B.,Vela-Rodriguez, C.,Korn, P.,Lehtio, L.; Dimerization of human PARP15 is required for NAD+ binding and automodification; Biorxiv, 2025; DOI: 10.64898/2025.12.15.694324

Experimental method

X-RAY DIFFRACTION (1.9 Å)