9SV3

Local refinement of EloB/EloC/VHL/CV2a/14-3-3zeta/ERa from pose 1

This is a non-PDB format compatible entry.

Summary for 9SV3

• Entry DOI: 10.2210/pdb9sv3/pdb
• EMDB information: 55233
• Descriptor: Elongin-C, Elongin-B, Estrogen receptor, ... (6 entities in total)
• Functional Keywords: e3 ligase, von hippel-lindau, vhl, 14-3-3, estrogen receptor alpha, protac, proteolysis targeting chimera, degrader, ligase
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 7
• Total formula weight: 191320.79

Authors

Crowe, C.,Nakasone, M.A.,Harzing, T.,Verhoef, C.J.A.,Cossar, P.J.,Ciulli, A. (deposition date: 2025-09-30, release date: 2025-12-03)

• Primary citation: Verhoef, C.J.A.,Crowe, C.,Nakasone, M.A.,DeLaCuadra-Baste, A.,Harzing, T.,Span, N.A.S.,Sathe, G.,Iso, K.,Ottmann, C.,Brunsveld, L.,Ciulli, A.,Cossar, P.J.; Induced ubiquitination of the partially disordered Estrogen Receptor alpha protein via a 14-3-3-directed molecular glue-based PROTAC design; Biorxiv, 2025; DOI: 10.1101/2025.11.17.688825

Experimental method

ELECTRON MICROSCOPY (4.3 Å)