9SPR

p53 cancer mutant R282W in complex with DARPin C10

Summary for 9SPR

• Entry DOI: 10.2210/pdb9spr/pdb
• Descriptor: Cellular tumor antigen p53, DARPin C10, ZINC ION, ... (5 entities in total)
• Functional Keywords: p53, tumor suppressor, cancer mutation, protein stability, protein unfolding disease, designed ankyrin repeat proteins, thermostabilization, mutant p53 reactivation, cancer therapy, transcription
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 2
• Total formula weight: 36715.88

Authors

Balourdas, D.I.,Muenick, P.,Knapp, S.,Dotsch, V.,Joerger, A.C.,Structural Genomics Consortium (SGC) (deposition date: 2025-09-17, release date: 2026-04-22)

• Primary citation: Balourdas, D.I.,Muenick, P.,Knapp, S.,Dotsch, V.,Joerger, A.C.,Structural Genomics Consortium (SGC); p53 cancer mutant R282W in complex with DARPin C10; to be published,

Experimental method

X-RAY DIFFRACTION (1.66 Å)