9RL6

Structure Guided Optimisation of Niclosamide Derivatives as Direct STAT3 Inhibitors Targeting a Novel Binding Site

Summary for 9RL6

• Entry DOI: 10.2210/pdb9rl6/pdb
• Descriptor: DNA (5'-D(*TP*GP*CP*AP*TP*TP*TP*CP*CP*CP*GP*TP*AP*AP*AP*TP*CP*T)-3'), Isoform Stat3B of Signal transducer and activator of transcription 3, 5-chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenzamide, ... (4 entities in total)
• Functional Keywords: sh2 domain, protein dna complex, signal transducer, activator of transcription, duplex dna, nucleus, cytosol, transcription-dna complex, dna binding protein
• Biological source: Mus musculus (house mouse); More
• Total number of polymer chains: 2
• Total formula weight: 73903.78

Authors

Quamruzzaman, M.,Maneshi, P.,Knight, R.,Parkinson, G.N.,Wells, G. (deposition date: 2025-06-16, release date: 2026-06-24)

• Primary citation: Quamruzzaman, M.,Maneshi, P.,Knight, R.,Parkinson, G.N.,Wells, G.; Structure Guided Optimisation of Niclosamide Derivatives as Direct STAT3 Inhibitors Targeting a Novel Binding Site; To Be Published,

Experimental method

X-RAY DIFFRACTION (2.55 Å)