9RF5

M. tuberculosis meets European Lead Factory: identification and structural characterization of novel Rv0183 inhibitors using X-ray crystallography: ELF8

9RF5 の概要

• エントリーDOI: 10.2210/pdb9rf5/pdb
• 分子名称: Monoacylglycerol lipase, [(3~{R})-3-oxidanylpyrrolidin-1-yl]-[4-[2-[3-(trifluoromethyloxy)phenyl]-1,3-oxazol-5-yl]phenyl]methanone, (4S)-2-METHYL-2,4-PENTANEDIOL, ... (7 entities in total)
• 機能のキーワード: rv0183, inhibitor, monoacylglycerol lipase, hydrolase
• 由来する生物種: Mycobacterium tuberculosis H37Rv
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 34472.95

構造登録者

Riegler-Berket, L.,Goedl, L.,Oberer, M.,Polidori, N. (登録日: 2025-06-04, 公開日: 2025-08-13, 最終更新日: 2025-10-29)

• 主引用文献: Riegler-Berket, L.,Godl, L.,Polidori, N.,Aschauer, P.,Grininger, C.,Prosser, G.,Lichtenegger, J.,Sagmeister, T.,Parigger, L.,Gruber, C.C.,Reiling, N.,Oberer, M.; M. tuberculosis meets European lead factory:Identification and structural characterization of novel Rv0183 inhibitors using X-ray crystallography; Disease and Therapeutics, 1:100002-, 2025; DOI: 10.1016/j.dist.2025.100002

実験手法

X-RAY DIFFRACTION (1.8 Å)