9QEM

Crystal structure of YTHDF2 in complex with compound 3 (AI-DF2-11)

This is a non-PDB format compatible entry.

Summary for 9QEM

• Entry DOI: 10.2210/pdb9qem/pdb
• Descriptor: YTH domain-containing family protein 2, 5-[[(3-methoxyphenyl)amino]methylidene]-2-sulfanylidene-1,3-diazinane-4,6-dione, GLYCEROL, ... (6 entities in total)
• Functional Keywords: inhibitor, m6a reader, rna binding protein
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 2
• Total formula weight: 39990.25

Authors

Nai, F.,Invernizzi, A.,Caflisch, A. (deposition date: 2025-03-10, release date: 2025-07-09)

• Primary citation: Invernizzi, A.,Nai, F.,Bedi, R.K.,Vargas-Rosales, P.A.,Li, Y.,Bochenkova, E.,Herok, M.,Zalesak, F.,Caflisch, A.; Discovery of YTHDF2 Ligands by Fragment-Based Design; Acs Bio Med Chem Au, 2025; DOI: 10.1021/acsbiomedchemau.5c00099

Experimental method

X-RAY DIFFRACTION (2.26 Å)