9OHM

Cryo-EM structure of bovine phosphodiesterase 6 bound to CB-5083

9OHM の概要

• エントリーDOI: 10.2210/pdb9ohm/pdb
• EMDBエントリー: 70500
• 分子名称: Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha, Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta, Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma, ... (7 entities in total)
• 機能のキーワード: gaf domain, phosphohydrolase, g protein-coupled receptor signaling, signaling protein, cb-5083
• 由来する生物種: Bos taurus (domestic cattle); 詳細
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 218976.68

構造登録者

Crawford, J.,Munuganti, R.,Leung, C.,Singh, K.,Gates, E.,Zhu, X.,Bally, M.,Dos Santos, N.,Sharifiaghdam, M.,Nosrati, Z.,Axerio-Cilies, P.,Berezuk, A.,Cholak, S.,Cameron, D.,Subramaniam, S. (登録日: 2025-05-05, 公開日: 2026-05-27)

• 主引用文献: Crawford, J.,Munuganti, R.,Leung, C.,Singh, K.,Gates, E.,Zhu, X.,Bally, M.,Dos Santos, N.,Sharifiaghdam, M.,Nosrati, Z.,Axerio-Cilies, P.,Berezuk, A.,Cholak, S.,Cameron, D.,Subramaniam, S.; Cryo-EM-guided subtractive optimization of a novel VCP/p97 inhibitor; To Be Published,

実験手法

ELECTRON MICROSCOPY (2.72 Å)