9OFX

Crystal structure of c-Src SH3 domain in H32 space group mediated by nickel

9OFX の概要

• エントリーDOI: 10.2210/pdb9ofx/pdb
• 分子名称: Proto-oncogene tyrosine-protein kinase Src, NICKEL (II) ION, GLYCEROL, ... (4 entities in total)
• 機能のキーワード: sh3 domain, nickel, src, atcun, signaling protein
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 27427.02

構造登録者

Stiegler, A.L.,Calicdan, X.,Ha, B.H.,Fisher, O.S.,Boggon, T.J. (登録日: 2025-04-30, 公開日: 2025-05-14, 最終更新日: 2026-01-07)

主引用文献

Calicdan, X.,Fisher, O.S.,Ha, B.H.,Boggon, T.J.,Stiegler, A.L.
Nickel Binding to the c-Src SH3 Domain Facilitates Crystallization.
Protein Pept.Lett., 32:679-692, 2025

PubMed Abstract: Numerous X-ray crystal structures of the c-Src SH3 domain have provided a large sampling of atomic-level information for this important signaling domain. Multiple crystal forms have been reported, with variable crystal lattice contacts and chemical crystallization conditions.

PubMed: 41088944
DOI: 10.2174/0109298665417324250929120040

実験手法

X-RAY DIFFRACTION (1.45 Å)