9ODX

Structure of Unc119B in complex with N-acetyl-S-geranylgeranyl-L-Cysteine

これはPDB形式変換不可エントリーです。

9ODX の概要

• エントリーDOI: 10.2210/pdb9odx/pdb
• 分子名称: Protein unc-119 homolog B, N-acetyl-S-geranylgeranyl-L-cysteine, SULFATE ION, ... (4 entities in total)
• 機能のキーワード: unc119, transport protein, lipid binding protein
• 由来する生物種: Mus musculus (house mouse)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 26503.80

構造登録者

Srivastava, D.,Sebag, J.A.,Artemyev, N.O. (登録日: 2025-04-28, 公開日: 2025-09-03)

主引用文献

Mittal, A.,Buscaglia, P.,Srivastava, D.,Artemyev, N.O.,Sebag, J.A.
Inhibition of Unc119b improves insulin sensitivity through potentiation of Rac1 activation in skeletal muscle and brown adipose tissue.
Mol Metab, 100:102230-102230, 2025

PubMed Abstract: A hallmark of type II diabetes is an impairment of the glucose transporter GLUT4 translocation to the plasma membrane of specialized cells in response to insulin. Identifying mechanisms involved in this defect is critical to developing treatments that restore insulin sensitivity. We previously identified a small molecule insulin sensitizer, C59, which improves insulin-stimulated GLUT4 translocation through binding to Unc119b, however, the role and mechanism of Unc119b-mediated regulation of GLUT4 trafficking is unknown.

PubMed: 40754229
DOI: 10.1016/j.molmet.2025.102230

実験手法

X-RAY DIFFRACTION (1.45 Å)