9OD9

Structure of disulfide-stabilized IL-18 variant

Summary for 9OD9

• Entry DOI: 10.2210/pdb9od9/pdb
• Descriptor: Interleukin-18 (2 entities in total)
• Functional Keywords: protein structure, cytokine
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 1
• Total formula weight: 19163.52

Authors

Sun, D.,Masureel, M.,Bainbridge, T.,Bulutoglu, B. (deposition date: 2025-04-25, release date: 2025-07-30)

Primary citation

Bainbridge, T.W.,Wang, L.,Moskalenko, M.,Herrera, R.,Paluch, M.T.,Sun, D.,Tasneem, K.,Saini, H.,Sadek, M.,Kwong, M.,Kim, Y.M.,Bhatt, J.M.,Tam, C.,Chan, P.P.F.,Ovacik, A.M.,Masureel, M.,Zhao, Y.,Sockolosky, J.T.,Qu, Y.,West, N.R.,Bulutoglu, B.
Engineered IL-18 variants with half-life extension and improved stability for cancer immunotherapy.
J Immunother Cancer, 13:-, 2025

PubMed Abstract: The pro-inflammatory cytokine, interleukin-18 (IL-18), plays an instrumental role in bolstering anti-tumor immunity. However, the therapeutic application of IL-18 has been limited due to its susceptibility to neutralization by IL-18 binding protein (IL-18BP), short in vivo half-life, and unfavorable physicochemical properties.

PubMed: 40664452
DOI: 10.1136/jitc-2025-011789

Experimental method

X-RAY DIFFRACTION (1.6 Å)