9OBE

Crystal structure of human Argonaute2 in complex with a fully modified siRNA with a 5'-phenylpropyl phosphate

This is a non-PDB format compatible entry.

Summary for 9OBE

• Entry DOI: 10.2210/pdb9obe/pdb
• Related: 9OBD
• Descriptor: Protein argonaute-2, fully modified siRNA with a 5' phenylpropyl phosphate, MAGNESIUM ION, ... (5 entities in total)
• Functional Keywords: ago2, sirna, phosphorothioate, hydrolase
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 2
• Total formula weight: 104775.45

Authors

Gebert, L.F.R.,MacRae, I.J. (deposition date: 2025-04-22, release date: 2026-04-29)

• Primary citation: Gebert, L.F.R.,MacRae, I.J.; Discovery of Argonaute2 compatible 5'-Alkylated phosphate stabilization chemistry for siRNA guide strand; To Be Published,

Experimental method

X-RAY DIFFRACTION (2.3 Å)