9O7H

CHIP E3 ligase dimer bound to 1 Fab 2D2

Summary for 9O7H

• Entry DOI: 10.2210/pdb9o7h/pdb
• EMDB information: 70199
• Descriptor: E3 ubiquitin-protein ligase CHIP, 2D2 Fab light chain, 2D2 Fab heavy chain (3 entities in total)
• Functional Keywords: u-box e3 ligase, fab, cryo-em, protein degradation, ligase-immune system complex, ligase/immune system
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 4
• Total formula weight: 111942.38

Authors

Unnikrishnan, A.,Southworth, D. (deposition date: 2025-04-15, release date: 2026-05-13)

• Primary citation: Unnikrishnan, A.,Southworth, D.; Structures of Fab-stabilized CHIP reveal a conformational switch important in E3 ligase and chaperone functions; To Be Published,

Experimental method

ELECTRON MICROSCOPY (4.8 Å)