9O7E

CHIP E3 ligase dimer in intermediate state bound to 2 Fab H1

Summary for 9O7E

Entry DOI	10.2210/pdb9o7e/pdb
EMDB information	70196
Descriptor	E3 ubiquitin-protein ligase CHIP, H1 Fab light chain, H1 Fab heavy chain, ... (4 entities in total)
Functional Keywords	u-box e3 ligase, fab, cryo-em, protein degradation, ligase-immune system complex, ligase/immune system
Biological source	Homo sapiens (human) More
Total number of polymer chains	6
Total formula weight	145178.06
Authors	Unnikrishnan, A.,Southworth, D. (deposition date: 2025-04-15, release date: 2026-05-13)
Primary citation	Unnikrishnan, A.,Southworth, D. Structures of Fab-stabilized CHIP reveal a conformational switch important in E3 ligase and chaperone functions To Be Published,
Experimental method	ELECTRON MICROSCOPY (3.9 Å)

Structure validation