9O15

Crystal Structure of BCL-2 (G101V) mutant in complex with a stapled BAD BH3 peptide BAD SAHB 4.2

Summary for 9O15

• Entry DOI: 10.2210/pdb9o15/pdb
• Descriptor: Apoptosis regulator Bcl-2,Bcl-2-like protein 1, stapled BAD BH3 peptide BAD SAHB 4.2 (3 entities in total)
• Functional Keywords: apoptosis regulator, stapled peptide, apoptosis
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 14
• Total formula weight: 138647.39

Authors

Seo, H.-S.,DeAngelo, T.M.,Bird, G.H.,Walensky, L.D.,Dhe-Paganon, S. (deposition date: 2025-04-03, release date: 2025-10-08)

• Primary citation: DeAngelo, T.M.,Adhikary, U.,Korshavn, K.J.,Seo, H.S.,Brotzen-Smith, C.R.,Camara, C.M.,Dhe-Paganon, S.,Bird, G.H.,Wales, T.E.,Walensky, L.D.; Structural insights into chemoresistance mutants of BCL-2 and their targeting by stapled BAD BH3 helices; Nat Commun, 16:8623-, 2025; DOI: 10.1038/s41467-025-63657-y

Experimental method

X-RAY DIFFRACTION (1.99 Å)