9NIZ

FphI, Staphylococcus aureus fluorophosphonate-binding serine hydrolases I, in complex with Carbamoyl Fluoride compound 18

This is a non-PDB format compatible entry.

Summary for 9NIZ

• Entry DOI: 10.2210/pdb9niz/pdb
• Descriptor: Serine aminopeptidase S33 domain-containing protein, 1,3-dihydro-2H-isoindole-2-carbaldehyde, CALCIUM ION, ... (4 entities in total)
• Functional Keywords: inhibitor, carboxylesterase, covalent warhead, carbamoyl fluoride, hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Staphylococcus aureus subsp. aureus USA300
• Total number of polymer chains: 1
• Total formula weight: 27953.60

Authors

Randall, G.T.,Meden, A.,Knez, D.,Fellner, M. (deposition date: 2025-02-26, release date: 2026-04-01, Last modification date: 2026-04-15)

• Primary citation: Randall, G.,Meden, A.,Rutledge, M.T.,Prestresi, L.,Rambaher, M.H.,Chen, S.,Zdovc, I.,Gobec, S.,Knez, D.,Fellner, M.; Carbamoyl fluorides as serine hydrolase inhibitors: a case study on FphI from Staphylococcus aureus; Bioorg.Chem., :109834-, 2026; DOI: 10.1016/j.bioorg.2026.109834

Experimental method

X-RAY DIFFRACTION (1.4 Å)